DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam34l

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_001020411.1	Gene:	Adam34l / 384813	MGIID:	3647273	Length:	736	Species:	Mus musculus

Alignment Length:	660	Identity:	141/660 - (21%)
Similarity:	220/660 - (33%)	Gaps:	218/660 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   426 IREGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDD 490
            :|.|:::.:..::..:.|....          |.:...|.|    ..|.||.|.:.|   .||.:
Mouse   171 MRCGLSEEEIAQQMNLQESNAS----------TLLQIPYEN----WWTHHRFIDYFV---VIDHN 218

  Fly   491 SACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASG 555
              |....|........:.:.|.|.:|.:.|:..:|..|..|..:..  ...:.:.  ...|.|..
Mouse   219 --CYVHRNNNTTTCIQDMLQVVNGINGYFLQIQTDVVLTKVEVWSQ--NNLINVE--EEMSAALD 277

  Fly   556 GICEKYK------------------TYTETVG----GQYQSTKRSLNTGIITFVNYNSRVPPKVS 598
            ..|...|                  .|.:.:|    ||...|   ||..:      ||.:...:|
Mouse   278 AFCSWKKNAIGNRVRHDIIHLFVRHNYVKFLGMAKLGQVCLT---LNCAV------NSFLTDSLS 333

  Fly   599 QLT--LAHEIGHNFGSPHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVL 661
            .|.  :|||:|||.|..|| ...| ..||: ..||:..|..     :.|||.||...:.:|::
Mouse   334 YLAFIVAHEMGHNLGMKHD-GSAC-TCGLH-TCIMYPYAYI-----SPKFSNCSYEEMFSVVN-- 388

  Fly   662 VGNTKRDCFKASEGA---------FCGNKIVESGEECDCGFNEEEC-KDKCCYPRLISEYDQSLN 716
                :|.|......|         .|||.:||.||:|||| |.|.| :|.||
Mouse   389 ----RRSCLYNIPDALKTITLVPTMCGNNLVEEGEQCDCG-NSESCLQDPCC------------- 435

  Fly   717 SSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEE-TECSWSSTCNGTTAECPEPRHRD 780
              :..|..:...:|  :.|.||  ..|.|:.|.  ..|::| .||.....||||:.|||...::.
Mouse   436 --SSDCVLKPGAKC--AFGLCC--KDCQFLQTG--TVCRQEKNECDLPEWCNGTSGECPGDVYKA 492

  Fly   781 DKTMCNNGTALCIRGECS-----------------------------------GSPCLLWNMTKC 810
            |...|:.| ..|.:.||.                                   |:...::.  :|
Mouse   493 DGIRCSRG-GYCYKMECQRHDRQCREIFGKRSRSADEICYMEMNRRGDRFGNCGNDSSMYK--RC 554

  Fly   811 FLTSTTLPHVSKRKLCDLACQDGNDT--------STCRSTSEFADKYNIQKGGISLQPGSPCD-- 865
            .||......:....:..|..:..::|        :|| .|.::.....|...| ::..|:||.
Mouse   555 ELTDVLCGRIQCENVIKLPQRRNHETVHYTHFSNNTC-WTMDYHFGITIDDVG-AVSDGTPCAPD 617

  Fly   866 -----------------------NFQGYCDVFLKCR-----------------AVDADGPLLRLK 890
                                   :.||.|:....|.                 ::|:..|.:.|.
Mouse   618 HICLDRKCVSKSVLVSNCTPHLCHMQGVCNNKHHCHCTNTWEPPDCQLHGHGGSIDSGPPPVPLS 682

  Fly   891 NLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIV--VMGSFIKCCAVHTPSSNPKKRRARRISETLR 953
                            ..||.:..|   |||:  |:| ||   |::......||.....:.|:..
Mouse   683 ----------------PSNWSMYFL---AFIIMYVLG-FI---ALYGIRELRKKLLKESVPESDS 724

  Fly   954 APMNTLRRMQ 963
            ...|..|:.|
Mouse   725 GDKNLTRKQQ 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	61/283 (22%)
		Reprolysin_2	450..659	CDD:290307	55/232 (24%)
		Disintegrin	684..776	CDD:278623	32/93 (34%)
Adam34l	NP_001020411.1	Pep_M12B_propep	41..159	CDD:366707
		ZnMc_adamalysin_II_like	207..395	CDD:239797	52/219 (24%)
		Disintegrin	416..488	CDD:365943	32/93 (34%)
		ACR	492..628	CDD:214743	20/140 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836130
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850