Protein Alignment kuz and Adam20

DIOPT Version :10

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_001009548.1
• Gene: Adam20 / 384806
• MGIID: 2152342
• Length: 760
• Species: Mus musculus
• Alignment Length: 548
• Identity: 130/548 - (23%)
• Similarity: 188/548 - (34%)
• Gaps: 197/548 - (35%)

  Fly   515 LNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSL 579
            ||:....|     :|::|....| |..||||:|       |.:|                 ..|.
Mouse   300 LNIRIPND-----IAHLFVNHSF-GKFLGLAYV-------GTVC-----------------LPSH 334

  Fly   580 NTGIITFVNYNSRVPPKVSQLT--LAHEIGHNFGSPHDYPQECRPGGLNGNYIMFASATSGDRPN 642
            |.|:      :..:.|.:.|..  :|||||||.|..|| ...|..||:  ||.:.:|..|    .
Mouse   335 NCGV------DRLLGPNLFQFAHIIAHEIGHNLGMEHD-SSSCTCGGI--NYCLMSSTYS----F 386

  Fly   643 NSKFSPCSIRNI------SNVL---DVLVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEEC 698
            |.:||.||..|.      :|.|   .:.:||.:..        ||||.:|:.||:|||| :...|
Mouse   387 NPEFSNCSYSNFWTTYATTNCLRKEKMSIGNLQIQ--------FCGNGVVDDGEQCDCG-DRHMC 442

  Fly   699 -KDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEE-TECS 761
             :|:||..|.      :||..| .|          :.|.|||  .|..:|..  ..|:|| .||.
Mouse   443 ERDQCCNSRC------ALNDGA-AC----------AFGLCCL--YCQIMPAG--TVCREEVNECD 486

  Fly   762 WSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSKRKLC 826
            ....|||.:.:||...:..|.:.|.:| ..|....|:..
Mouse   487 LPEWCNGHSHKCPNDVYLLDGSPCRDG-GYCYEKRCNNR-------------------------- 524

  Fly   827 DLACQD-------GNDTSTCRSTSEFADKYNIQKGGISLQPGSPCDNFQGYC----DVFLKCRAV 880
            |..|:.       ..|.|..|..:...|::                   |.|    |.:|:|...
Mouse   525 DEQCKQIFGKEARSADHSCYRELNTQGDRF-------------------GNCGMIRDAYLRCHDS 570

  Fly   881 DADGPLLRLKNL-----LLNRKT-----LQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAVHT 935
            |.....::.:|:     |.:..|     |..|..|..|..:.:.:..:. ||..|:  .|...|.
Mouse   571 DILCGRVQCENVTRIPFLRDHSTVHWTHLNGVTCWGTDYHFGMTIPDIG-IVKDGT--DCGPEHV 632

  Fly   936 PSSNPKKRRARRI--------SETLRAPMNTLRRMQRHPNQRGAGPRSIPPPAHEAQHYSRGGD- 991
            ..:  ||..::.|        :.|::...|.|...                      |.:||.|
Mouse   633 CIN--KKCVSKPIWLEQCSSKTCTMKGVCNNLHHC----------------------HCNRGWDP 673

  Fly   992 ------GRGGGGGGGGRHGGSRSHHQQH 1013
                  |.||....|...|...|  |||
Mouse   674 PHCLESGFGGSVDSGPPPGEEES--QQH 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	Pep_M12B_propep	54..149	CDD:460254
		ZnMc_TACE_like	410..677	CDD:239798	46/172 (27%)
		Disintegrin	684..776	CDD:459709	31/93 (33%)
Adam20	NP_001009548.1	Pep_M12B_propep	57..173	CDD:460254
		ZnMc_adamalysin_II_like	222..408	CDD:239797	43/150 (29%)
		Disintegrin	429..501	CDD:459709	31/93 (33%)
		ACR	505..641	CDD:214743	31/186 (17%)