DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and Meltrin

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster

Alignment Length:	1313	Identity:	255/1313 - (19%)
Similarity:	403/1313 - (30%)	Gaps:	448/1313 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 PSTSTTSSATTATKSTQPTRPLAKSNTSTTAVNSKTENFIKKIAESTTTSQQLPEYTESSSSSTT 230
            |:.:|....:...||  ...|:.:..::.|.:..:.|:...|.:..||.......:|...|.|.|
  Fly    25 PAEATAFHQSEGEKS--KAHPVLEEFSTYTVIRPQVEHGRTKRSLLTTLDATDGLHTPQISLSYT 87

  Fly   231 TFPPTTEYFEDEKERNAEDELDFHSIIYKESHVEDAYENVREGHVAGCGITD------EVSQWME 289
                      .|.:|...| |..:.::...||.. .|:|...|...|..:|.      ::..:..
  Fly    88 ----------HEGKRVVVD-LQRNDLLLPNSHFL-RYQNASRGATPGHVVTTFTKTEVDLCHYQG 140

  Fly   290 NIQNSAVEELPEPM----------------SKDYQKLH-----RKQLHKKSAPQQQQQPHPPKK- 332
            :|:..     ||.:                .:....:|     |.:|.......:|...||...
  Fly   141 HIRGK-----PESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNAT 200

  Fly   333 --YISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDR 395
              |.:..:|..:.::|...:.....|.   ||...||..    .::.:.:..:.|:|.|:....|
  Fly   201 CGYDNHRDDHSHDYEKADGDNGLGGGI---PSLPLRLDG----GEFSRTLLRKRRQADDSSQLIR 258

  Fly   396 GSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEITSLIAHHVTAV 460
            |..         |.|..|.|::                                  |:   :...
  Fly   259 GPY---------NANKYSSYVE----------------------------------LV---IVVD 277

  Fly   461 NYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFC--------NEHMDVS----- 512
            |.:|:|.:.:.:..|:..:.....|         |:...|.|.|.        ||..::.
  Fly   278 NKVYKNFQENTKKVHQYCKGIANII---------NALYVPLNIFVALVGVVIWNESNEIEFSSDG 333

  Fly   513 -----NFLNLHSLE---DHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVG 569
                 ||||..|.:   ||.: ..|.:.|..:|.||.:|.|       ..|.||    || |..|
  Fly   334 DLTLRNFLNYRSTKLVLDHPN-DNAQLLTKENFAGGVVGKA-------LKGPIC----TY-EYSG 385

  Fly   570 GQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQ-ECRPGGLNGNYIMFA 633
            |  .|.:.|.|              |.:...|:|||:|||||..||... .||    :...:|.|
  Fly   386 G--VSMQHSPN--------------PAMVATTMAHEMGHNFGMEHDTSDCHCR----DEKCVMAA 430

  Fly   634 SATSGDRPNNSKFSPCSIRNI----SNVLDVLVGNTKRDCFKASEGAFCGNKIVESGEECDCGFN 694
            |:||....|   :|.|||..:    |..::..:.|.....|   |...|||..||.||:||||.
  Fly   431 SSTSFIPVN---WSSCSIDQLTIAFSRGMNYCLRNKPERLF---ESPTCGNGFVEPGEQCDCGL- 488

  Fly   695 EEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKE-ET 758
            .|.|::.||              :|:.|...:| ..:.:.|.||...:|.  |......|:| |.
  Fly   489 PEHCENACC--------------NAQTCMLHSK-NATCATGECCDLTTCR--PKLAGSACREAEN 536

  Fly   759 ECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGEC--SGSPC-LLW-----NMTKCF---- 811
            ||.....|.|.:..||....|.|...|:.|.|.|..|.|  ..:.| .||     |...|:
  Fly   537 ECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNSEHCYNKNT 601

  Fly   812 ------------LTSTTLP--------------HVSKR--------------------------- 823
                        |..|.|.              |:::|
  Fly   602 EGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRT 666

  Fly   824 KLCDLACQDGNDTSTCRSTSEFADKYNI-----------QKGGISLQPGSPCD---------NFQ 868
            .|.||..|..:...|........||..:           |||     .|.||.         |.:
  Fly   667 ALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKG-----MGKPCPEDCNGNGICNSR 726

  Fly   869 G--YCDVFL---KCR------------AVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLM 916
            |  :|||..   .|.            |.|.:|. :..|..|                  .|:..
  Fly   727 GHCHCDVGFGGESCSKAGSGGSPDSGPATDPNGS-VGFKRFL------------------YVLFF 772

  Fly   917 GVAFIVVMGSFIKCCAVHTPSSNPKKRRARRISETLRA-----PMNTLRRMQRHPNQRGAGP--- 973
            .|..:|.:..|:..|     ..|....|.:.....|::     |:.|      ..||.|.||
  Fly   773 FVLPVVALFWFLYHC-----YKNGMLTRGKLADNILKSSGGSKPITT------RTNQNGTGPPPS 826

  Fly   974 ----RSIPPPAHEAQHYSRGGDGRGGGGGGGGRHGGSRSHHQQHPHDWDRHQG------GHSIVP 1028
                :|.|....:..                       |...:.|.|.....|      |.::.|
  Fly   827 NGLLKSTPSSTDDMD-----------------------SALLKSPSDSTPSAGLFGKFDGFTLRP 868

  Fly  1029 LPTGGSHSSRNSAANQA-----RRSDGRGPRSTSSGRPQAIASGSGAAS-GAARSHGGYGAEQAI 1087
            |....|.:|..:..|.|     .:.||          ||.:|....... |.|..|......:|.
  Fly   869 LNDASSPASNYNGPNVAFVQPTVQQDG----------PQRMAPPPPVVKPGTAPIHPPSPKPEAT 923

  Fly  1088 ---------PGSIGGGVQAAISSGGV------------------VARAQLPLPL----------- 1114
                     |.:.|...:..||...:                  .:|:..|:||
  Fly   924 WVRPAPALPPPNPGSTARPIISPPKLDSSTLTMVPLKDSTEDLSPSRSAPPVPLHADPKLNVKRD 988

  Fly  1115 ---------------PPPNGQQQMQQQ--QQLQLQQPAISPQQQPQQAFYTPKELPPRNKSRSSR 1162
                           ||...:..:.::  :.|::..|...|.....::..:..|..||.:...:.
  Fly   989 GTIRRFASFLKKEEKPPLKEKTYIDRERLRTLEISAPMPVPAAPQAESSNSDSETTPREEETQNL 1053

  Fly  1163 TNNTSNTTTTTNSSTAAAGSGSVSGPGSGAGSSSKSKSGKSAKAKDSKSQKS----QQANNSRSS 1223
            .....:..:.|..:...:.....|.||.....|.:..|..:::.|....:..    ::.|:..||
  Fly  1054 VKRAQSMRSPTKKAPLQSFGSMRSPPGLPRPKSGQVNSNGASRPKSPPPRPPPVVVKKTNSISSS 1118

  Fly  1224 SKEKGVKPVRRNI 1236
            ..::.|...:|::
  Fly  1119 GYQRPVSTAQRSV 1131

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	68/292 (23%)
		Reprolysin_2	450..659	CDD:290307	62/234 (26%)
		Disintegrin	684..776	CDD:278623	28/92 (30%)
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	21/126 (17%)
		Reprolysin	269..464	CDD:279729	64/276 (23%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	63/274 (23%)
		Disintegrin	479..555	CDD:278623	28/93 (30%)
		ACR	558..701	CDD:214743	24/142 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.920