DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and adam8a

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_956931.1	Gene:	adam8a / 368917	ZFINID:	ZDB-GENE-030616-622	Length:	843	Species:	Danio rerio

Alignment Length:	848	Identity:	188/848 - (22%)
Similarity:	270/848 - (31%)	Gaps:	319/848 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   430 IADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIR-----FEV--QRIKI 487
            :.|:...:|:...:|. ||...|:|:|   |:.:||..         |||     .||  ||..|
Zfish   204 VVDNTEYKKFGSFKKI-EERMMLVANH---VDKLYRPL---------NIRVMLVGLEVWSQRDLI 255

  Fly   488 DDDSACRNSYNGPHNAFCNEHMDVSNFL-----NLHSLEDHSDFCLAYVFTYRDFTGGTLGLA-- 545
            |..|              ..::.:..||     :|...:.|.:   |:..|..||.|.|:|||
Zfish   256 DVSS--------------RPNLTLERFLKWRRDSLLQRKKHDN---AHFITGIDFEGSTVGLATL 303

  Fly   546 WVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNF 610
            :...:|.:||.:.|                            ::||.  |.....|:|||:|||.
Zfish   304 YAMCSSSSSGAVNE----------------------------DHNSN--PIAVASTVAHEMGHNL 338

  Fly   611 GSPHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCF----- 670
            |..|| ...|   |.:.|.......|.|....:| ||.||..::...|:    |...:|.
Zfish   339 GMSHD-DSSC---GCSSNKGCIMGDTIGSIYPDS-FSTCSQSSLKAFLE----NYDTNCLIDVPN 394

  Fly   671 --KASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPS 733
              :...|..|||..||.||||||| ..|||.:.||              :|..|......:|  :
Zfish   395 EGQIYGGPVCGNAFVEKGEECDCG-TVEECNNPCC--------------NATTCRLTEGARC--A 442

  Fly   734 QGPCCLSNSCTFVPTSYHQKCKEET-ECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGEC 797
            .|.||  ::|....|.  ..|::.. :|.....|.|.:|.|||..::.:...||.....|..|:|
Zfish   443 HGECC--HNCQLKHTG--SLCRKSAHDCDLDEYCTGESAFCPEDDYKMNGLPCNYNQGYCYNGQC 503

  Fly   798 --SGSPC-LLWNM------TKCF------LTSTTLPHVSKRKLCDLACQDGN------------- 834
              ....| :||..      ..||      .||.:..|   ||...:.|..||
Zfish   504 PTHKEHCKMLWGSGADVDDDACFQYNVIDRTSKSAEH---RKCGRIYCYGGNPFPKTNKKANVNV 565

  Fly   835 DTSTC---RSTSEFADKYNIQKG---------------GISLQPGSPCD---NFQGYCDVFLKCR 878
            .:.||   ..:|...|...:..|               .||:.....|.   |.:|.|:..|||.
Zfish   566 QSRTCYMALDSSPTEDLGMVPTGTKCGTNKVCYKSLCLDISMYGTENCSNKCNNRGVCNHELKCH 630

  Fly   879 AVDADGPL---LRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGV-------AFIVVMGSFIKCCAV 933
            ......|.   ::|..|...||:               |::||       ..|:::|:.:
Zfish   631 CDPGWAPPYCDIQLSELHKMRKS---------------VVIGVTTSLAILVLIIIIGALV----- 675

  Fly   934 HTPSSNPKKRRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIPPPAHEAQHYSRGGDGRGGGGG 998
                                ...|.:...::...|:|.             |.|.|
Zfish   676 --------------------YNRNKITEFRKKRPQKGI-------------HSSSG--------- 698

  Fly   999 GGGRHGGSRSHHQQHPHDWDRHQGGHSIVPLPTGGSHSSRNSAANQARRSDGRGPRSTSSGRPQA 1063
                        |.:|    ..|.|                ||.|..|.:.   ||.:   :|..
Zfish   699 ------------QCNP----AFQPG----------------SAKNSPRIAQ---PRIS---QPTF 725

  Fly  1064 IASGSGAASGAARSHGGYGAEQAIPGSIGGGVQAAISSGGVVARAQLPLPLPPPNGQQQMQQQQQ 1128
            :.|.:..|....||       .|:|..                    |.|:||.|..|...:
Zfish   726 LESSATQACKPLRS-------AAMPCR--------------------PAPMPPKNAPQTRNE--- 760

  Fly  1129 LQLQQP-----AISPQQQPQQA---FYTPKELPPRNKSRSSRTNNTSNTTTTTNSSTAAAGSGSV 1185
             |:.:|     |||....|.||   ....|.|||      ||......:...|.|.:........
Zfish   761 -QIMKPPVPPSAISKNIYPPQAKPLLPAAKPLPP------SRPLPPLASKAVTKSKSPPVPPVKP 818

  Fly  1186 SGP 1188
            |||
Zfish   819 SGP 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	65/267 (24%)
		Reprolysin_2	450..659	CDD:290307	56/222 (25%)
		Disintegrin	684..776	CDD:278623	28/92 (30%)
adam8a	NP_956931.1	Pep_M12B_propep	42..157	CDD:279848
		Reprolysin	199..393	CDD:279729	64/257 (25%)
		ZnMc_adamalysin_II_like	199..389	CDD:239797	63/253 (25%)
		Disintegrin	410..482	CDD:278623	28/92 (30%)
		ACR	486..605	CDD:214743	23/121 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920