DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam32

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_001164053.1	Gene:	Adam32 / 361170	RGDID:	735114	Length:	752	Species:	Rattus norvegicus

Alignment Length:	302	Identity:	67/302 - (22%)
Similarity:	104/302 - (34%)	Gaps:	93/302 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   519 SLEDHSDFCLAYVFTYRD---FTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLN 580
            :|..|.   :||:|.|.:   :.|.|.           .|.:|    |...:.|
  Rat   267 TLRPHD---VAYLFIYNEQPNYMGATY-----------PGKMC----TAPYSAG----------- 302

  Fly   581 TGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGG----LNGNYIMFASATSGDRP 641
               ||.  |...:..:...:.|...:|.:.|..:|.|::|....    :|...:.:....:
  Rat   303 ---ITM--YPKDMTLEAFSVILTQMLGLSLGISYDNPEKCHCSEKVCIMNPRAMQYTGVKT---- 358

  Fly   642 NNSKFSPCSIRNISNVLDVLVGNTKRDCFKASEG---------------AFCGNKIVESGEECDC 691
                ||.||..:...             ||.:||               |.|||..||..|.|||
  Rat   359 ----FSNCSSNDFER-------------FKLNEGAKCLQNKPEMQRSPRAVCGNGKVEGDEICDC 406

  Fly   692 GFNEEEC-KDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCK 755
            | ::::| .:.||.|      ...:..|.|.|     ...||| ..||  ..|.|:|..:..:..
  Rat   407 G-SQQQCGANSCCEP------TSCVLKSGKAC-----DSMSPS-ATCC--KDCQFLPDKHECRPS 456

  Fly   756 EETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGEC 797
            ....|..:..|||::.:||......:..:|..|..:|..|.|
  Rat   457 SNMYCDIAEVCNGSSGQCPPDIILSNGIICGEGGTVCYNGNC 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	30/179 (17%)
		Reprolysin_2	450..659	CDD:290307	26/146 (18%)
		Disintegrin	684..776	CDD:278623	27/92 (29%)
Adam32	NP_001164053.1	Pep_M12B_propep	46..143	CDD:279848
		Reprolysin	187..383	CDD:279729	30/170 (18%)
		ZnMc_adamalysin_II_like	187..381	CDD:239797	30/168 (18%)
		Disintegrin	399..478	CDD:278623	27/93 (29%)
		ACR	482..621	CDD:214743	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339796
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850