DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam11

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_017452891.1	Gene:	Adam11 / 360638	RGDID:	1307515	Length:	833	Species:	Rattus norvegicus

Alignment Length:	766	Identity:	165/766 - (21%)
Similarity:	239/766 - (31%)	Gaps:	276/766 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   424 RHIREG---------------IADHDRGRKYEVDEKTREEI--TSLIAHH-VTAVNYIYR---NT 467
            |.:|.|               |.||      ::.|:.|:.:  ||..|.. |...:.||:   ||
  Rat   229 RQVRRGHPTVHSETKYVELIVINDH------QLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNT 287

  Fly   468 KF---------DGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDH 523
            :.         ||           .:|::.||..              |.:..........|.:.
  Rat   288 RIVLVAMETWADG-----------DKIQVQDDLL--------------ETLARLMVYRREGLPEP 327

  Fly   524 SDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVN 588
            ||  ..::|:.|.|...:.|.|:|       ||||...:      ||           |:..:.|
  Rat   328 SD--ATHLFSGRTFQSTSSGAAYV-------GGICSLSR------GG-----------GVNEYGN 366

  Fly   589 YNSRVPPKVSQLTLAHEIGHNFG---SPH-DYPQECRPGGL--------NGNYIMFASATSGDRP 641
            ..:..      :|||..:|.|.|   :.| ....:|:...:        .|.|:          |
  Rat   367 MGAMA------VTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYL----------P 415

  Fly   642 NNSKFSPCSIRNISNVLDVLVGNTKRDC-----FKASEGAFCGNKIVESGEECDCGFNEEECK-- 699
            .  |||.|||...:..|....|:    |     .|..:...|||..||:||||||| :.:||.
  Rat   416 R--KFSRCSIDEYNQFLQEGGGS----CLFNKPLKLLDPPECGNGFVEAGEECDCG-SVQECSRA 473

  Fly   700 -DKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEE-TECSW 762
             ..||                |.||......|  |.|.||  ..|.:.|...  .|:|. .||..
  Rat   474 GGNCC----------------KKCTLTHDAMC--SDGLCC--RRCKYEPRGV--SCREAVNECDI 516

  Fly   763 SSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECS--GSPC-LLWNMTKCFLTSTTLPHVSKRK 824
            :.||.|.:::||...|:.|...|::....|..|.|.  ...| .||.            ||:..:
  Rat   517 AETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQALWG------------HVAADR 569

  Fly   825 LC-DLACQDGNDTSTCRSTSEFADKYNIQKGGISLQPGSPCDNFQGYCDVFLKC-------RAVD 881
            .| :....:|.:...|.           :||...:|    |:.....|. ||.|       |..|
  Rat   570 FCYEKLNVEGTERGNCG-----------RKGSGWVQ----CNKQDVLCG-FLLCVNISGAPRLGD 618

  Fly   882 ADGPLLRL------KNL--------LLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKC-- 930
            ..|.:..:      |.|        |.:...|..|.:.......::.|..........:|..|
  Rat   619 LGGDISSVTFYHQGKELDCRGGHVQLADGSDLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPG 683

  Fly   931 ------CAVHTPSSNPKKRRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIPPPAHEAQHYSRG 989
                  |:.|...||..|        .:..|..|.:....|      .|....||..|.:.|...
  Rat   684 SGERRICSHHGVCSNEGK--------CICQPDWTGKDCSIH------NPLPTSPPTGETERYKET 734

  Fly   990 GDGRGGGGGGGGRHGGSRSHHQQHP-----------HDWDRHQGGHSIVPLPTGGSHSSRNSAAN 1043
            ....|......|:   ..:.|...|           |..||..|     |:      .||:.|.:
  Rat   735 SVAEGMTRPSRGQ---CDAGHVIPPAVLVSISSVPLHSVDRELG-----PI------RSRSPAGS 785

  Fly  1044 QARR-----------SDGRGPRSTSSGRPQAIASGSGAASGAARSHGGYGA 1083
            ..:|           :...||     |.|.::.|.:|       |||..||
  Rat   786 LGKRIRCLLRPFLLPTRLLGP-----GSPSSVLSAAG-------SHGRVGA 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	60/299 (20%)
		Reprolysin_2	450..659	CDD:290307	48/233 (21%)
		Disintegrin	684..776	CDD:278623	31/95 (33%)
Adam11	XP_017452891.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920