Protein Alignment kuz and adam17a

DIOPT Version :9

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: XP_005158775.1
• Gene: adam17a / 324142
• ZFINID: ZDB-GENE-030131-2862
• Length: 848
• Species: Danio rerio
• Alignment Length: 1147
• Identity: 259/1147 - (22%)
• Similarity: 383/1147 - (33%)
• Gaps: 384/1147 - (33%)

  Fly     5 CAFNIVFVSIIFIIIVNGYAKDIS--GVKRGHERLNEYISHYETLN---YDHEHIRAS----HNR 60
            |.|.:|.::.:|   .:...|.:|  .|.|..|.|.|    ::.||   .|.|.:.||    |:.
Zfish     4 CIFYLVLLAPLF---AHCAVKPVSVEEVSRNEEELQE----FDALNSLLSDFEVLPASGLQLHSV 61

  Fly    61 ARRSVTKDQYVH--LKFASHGRDFHLRLKRDLNTFSNKLD--FYDSKG---PIDVSTDHIYEGEV 118
            .:|......:|.  :.|.:..|:|.|.|..:...|:....  |.|..|   ..||...:.::|.|
Zfish    62 RKRDADAHSHVERLVSFTALQRNFKLYLTTNTQLFTENFSAVFVDENGKEDQFDVQIQNYFKGHV 126

  Fly   119 IGDRNSYVFGSIHNGVFEGKIITERDAYYVEHAKHYFPTNRTATTTPPSTSTTSSATTATKSTQP 183
            :|:.:|.|...|....|...||||...|.||....:       |.|||
Zfish   127 VGEEHSRVQAHIDGDEFSAHIITEETEYNVEPLWRF-------TETPP----------------- 167

  Fly   184 TRPLAKSNTSTTAVNSKTENFIKKIAESTTTSQQLPEYTESSSSSTTTFPPTTEYFEDEKERNAE 248
                                                                             
Zfish   168 ----------------------------------------------------------------- 167

  Fly   249 DELDFHSIIYKESHVEDAYENVREGHVAGCGITDEVSQWMENIQNSAVEELPEPMSKDYQKLHRK 313
               |...::|:.   ||.....|......||.          :...|.|.|||
Zfish   168 ---DGRLLVYRS---EDIKNISRLSSPKVCGY----------VNADAQELLPE------------ 204

  Fly   314 QLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQ 378
              ..::|.:.::....|
Zfish   205 --EARAAEEMEEMKEEP------------------------------------------------ 219

  Fly   379 LVHERVRRATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDE 443
              |.|.||:|                .:..||||:|.:..|...::|:         ||
Zfish   220 --HNRERRST----------------HDQKKNTCTLLLVADHRFYKHM---------GR------ 251

  Fly   444 KTREEITSL--IAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDD----SACRNSYN--GP 500
              .||.|:|  :...:..|:.|||||.:|  .:.:....::|:|.|:.|    :.....||  |.
Zfish   252 --AEESTTLNYLIELIDRVDDIYRNTSWD--DDFKGYGVQIQQIIINKDPTKVAPGEFHYNMDGS 312

  Fly   501 HNAFCNEHMDVSNFLNLHSLE---DHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEK-- 560
            .....:...||...|...|.:   :.|..|||::|||:||..||||||:||.:....||:|.|
Zfish   313 PTGRKDGVWDVKKLLEQFSYDIAANASRACLAHLFTYQDFDDGTLGLAYVAPSKPGLGGLCPKPY 377

  Fly   561 YKTYTETVGGQYQSTKRS--LNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQ---EC 620
            |.:         ||.|:.  ||||:.:.:||...:..|.:.|...||:|||||:.|| |.   .|
Zfish   378 YPS---------QSVKKPSYLNTGLTSTMNYGKTILTKEADLVTTHELGHNFGAEHD-PDNIASC 432

  Fly   621 RPG-GLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCFKASEGAFCGNKIVE 684
            .|. ...|.|:|:..|.|||..||..||.||..::|..|.:.|    ..||.......|||..||
Zfish   433 APSDDQGGKYVMYPIAVSGDHVNNKHFSTCSKISVSKTLRIKV----NQCFVERSSKLCGNSRVE 493

  Fly   685 SGEECDCG---FNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFV 746
            ..|:||.|   .|:    |.||               ...|..|.:.|||....|||  .:|.|
Zfish   494 EDEDCDPGLLHIND----DPCC---------------TSNCKFRKQAQCSDRNSPCC--KNCMF- 536

  Fly   747 PTSYHQKCKE--ETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECSGSPC-----LL 804
             .|..:.|:|  ...|..:|.|.|.::|||.|.:.:|.|.|.:      :|.|....|     .:
Zfish   537 -ESADKVCQEVITATCKGTSQCTGNSSECPTPGNLEDNTECVD------KGRCQNGQCRPFCEAV 594

  Fly   805 WNMTKCFLTSTTLPHVSKRKLCDLACQD-GNDTSTCRSTSEFADKYNIQKGG--ISLQPGSPCDN 866
            .|:..|                  ||.: .|....|....|....:  ..||  :.|:.|.||.
Zfish   595 HNLESC------------------ACNETENSCKVCCRKDELCTPF--LNGGSFLYLRKGKPCT- 638

  Fly   867 FQGYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWY-LVVLMGVAFIVVMGSFIKC 930
             .|:||...||.....| .:.||.: .:::..:.|..:::.||.. .||:..:.|.:.:...:.|
Zfish   639 -VGFCDGAGKCMKQVQD-VIERLWD-FIDKLNINTFGKFLADNIVGSVVVFSLLFWIPISILVHC 700

  Fly   931 CAVHTPSSNPKKRR----ARRISETLRAPMNTLRRMQRHPNQRGAGPRSIPPPA----------- 980
            ..........:..:    ::.:.|.....:|:.|| ....:..||.|.|..|..
Zfish   701 VDKRLDEQYEENTKMMYPSQMVLEVCSRALNSERR-DTEQSGIGARPHSQGPSCTFTSSTTSALN 764

  Fly   981 --HEAQHYSRGGDGR------------GGGGGGGGRHGGSRSHHQQHPHDWDRHQGGHSIVPLPT 1031
              :..:.::..||.|            .|....|...||                        |.
Zfish   765 GPYRPRLHTGTGDARRPRPSQPLRRTQSGSAANGHNRGG------------------------PQ 805

  Fly  1032 GGSHSSRNSAANQARRSDG---RGPRSTSSGRPQAIASGSGA 1070
            ....|.|......|:|...   |||..|.:...|..|..:||
Zfish   806 RRLLSPRRGGRLPAKRHSCQVLRGPHRTGNTITQETAEETGA 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	93/285 (33%)
		Reprolysin_2	450..659	CDD:290307	79/227 (35%)
		Disintegrin	684..776	CDD:278623	29/96 (30%)
adam17a	XP_005158775.1	Pep_M12B_propep	62..161	CDD:279848	27/98 (28%)
		ZnMc_TACE_like	233..486	CDD:239798	93/285 (33%)
		Reprolysin_2	257..471	CDD:290307	78/225 (35%)
		Disintegrin	493..567	CDD:278623	29/96 (30%)
		ADAM17_MPD	590..648	CDD:293303	16/79 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920