DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam33

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_038960925.1	Gene:	Adam33 / 311425	RGDID:	1305278	Length:	799	Species:	Rattus norvegicus

Alignment Length:	753	Identity:	165/753 - (21%)
Similarity:	244/753 - (32%)	Gaps:	256/753 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 LAKSNTSTTAVNSKTENFIKKIAESTTTSQQL--PEYTESSSSSTTTFPPTTEYFEDEKERNAED 249
            ::|.::...|:.::.::.:.::.:    :.:|  |.|||            |.|..|.:
  Rat    63 ISKPDSGLVALKAEGQDLLLELEK----NHRLLAPGYTE------------TYYSRDGQ------ 105

  Fly   250 ELDFHSIIYKESHVEDAYENVREGHVAGC--GITDEVSQWMENIQNSAVEELPEPMSKDYQKLHR 312
                 .|:...:|.:..       |..||  |..:   .|:.....|.:..|....||....||
  Rat   106 -----PIVLSPNHTDHC-------HYQGCVRGFRE---SWVVLSTCSGMSGLIVLSSKVSYYLH- 154

  Fly   313 KQLHKKSAPQQQQQPHPPKKYISGD-EDFKYPHQKYTKEANFA-EGAFYDPSTGRRLGSSANVAD 375
                               .::.|| :||. .|:.:..|..|. .||..|.::..:.|    :|.
  Rat   155 -------------------PWMPGDTKDFP-THKIFRVEQLFTWRGARKDKNSQFKAG----MAR 195

  Fly   376 WHQLVHERVRRATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYE 440
            ...:.|.|:||                ..|...| ...|||..|..::...|:.: :|.|.|..|
  Rat   196 LPHVPHRRMRR----------------EARRSPK-YLELYIVADHALFLLQRQNL-NHTRQRLLE 242

  Fly   441 VDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKI---DDDSACRNSYNGPHN 502
            :               ...|:.|.|..         :|:..:..:::   .|.|......|....
  Rat   243 I---------------ANCVDQILRTL---------DIQLVLTGLEVWTEQDHSRITQDANETLW 283

  Fly   503 AFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTET 567
            ||.....      .|.....|..   ..:.|.|.|.|.|:|||.|.       |:|     :.|:
  Rat   284 AFLQWRR------GLWVRRPHDS---TQLLTGRTFQGTTVGLAPVE-------GMC-----HAES 327

  Fly   568 VGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQEC--RPGGLNGNYI 630
            .||                |:.:....|..:..|:||||||:.|..|| |:.|  ......|..:
  Rat   328 SGG----------------VSTDHSELPIGTAATMAHEIGHSLGLHHD-PEGCCMEADAEQGGCV 375

  Fly   631 MFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCFKASEGAF---------------CGN 680
            |  .|.:| .|....||.||.|.:            |..|:...||.               |||
  Rat   376 M--EAATG-HPFPRVFSACSRRQL------------RTFFRKGGGACLSNVSAPGLLVLPSRCGN 425

  Fly   681 KIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTF 745
            ..||:.||||||..::. .|.||:              |..|:.||..||  :||.||.  .|..
  Rat   426 GFVEAEEECDCGSGQKR-PDPCCF--------------AHNCSLRAGAQC--AQGDCCA--RCLL 471

  Fly   746 VPTSYHQKCK-EETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECSGSPCL------ 803
            .|..  ..|: ...:|.....|.||:..||...:..|.:.|..|...|:.|.|   |.|
  Rat   472 KPAG--TPCRPAANDCDLPEFCTGTSPHCPADVYLLDGSPCAEGRGYCLDGWC---PTLEKQCQQ 531

  Fly   804 LWN------MTKCFLTSTT----------------LPHVSKRKLC-DLACQDGNDT--------- 836
            ||.      ...||....:                ||...:...| .|.||.|...
  Rat   532 LWGPGSQPAPEPCFQQMNSVGNSQGNCGQDSKGSFLPCTQRDAQCGKLLCQGGKPNPLVPHVVTV 596

  Fly   837 -ST---------CRSTSEFADKYNIQKGGISLQPGSPC 864
             ||         ||......|.:..|.|...::||:.|
  Rat   597 DSTILLKGRQVLCRGAFVLPDTHLDQLGLGLVEPGTRC 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	61/271 (23%)
		Reprolysin_2	450..659	CDD:290307	49/213 (23%)
		Disintegrin	684..776	CDD:278623	29/92 (32%)
Adam33	XP_038960925.1	Pep_M12B_propep	41..170	CDD:396235	28/164 (17%)
		ZnMc_adamalysin_II_like	213..410	CDD:239797	63/275 (23%)
		DISIN	429..503	CDD:214490	29/94 (31%)
		ACR	505..647	CDD:214743	29/133 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920