Protein Alignment kuz and Adam19

DIOPT Version :9

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_001153700.1
• Gene: Adam19 / 303068
• RGDID: 1585017
• Length: 920
• Species: Rattus norvegicus
• Alignment Length: 1057
• Identity: 228/1057 - (21%)
• Similarity: 344/1057 - (32%)
• Gaps: 381/1057 - (36%)

  Fly   221 YTESSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYK--ESHVEDAYENVREGHVAGC-GITD 282
            ||.|.:..|||.             .:||...:|..:.|  ||.|.          ::.| ||..
  Rat    97 YTASGNPQTTTL-------------KSEDHCFYHGTVRKVDESSVT----------LSTCRGIRG 138

  Fly   283 EVSQWMENIQNSAVEEL--PEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQ 345
            .:      |..|.:..:  |.|.|.:..:::|.: |.|..|              |:..|:  |.
  Rat   139 LI------IVRSNLSYIIEPVPNSDNQHRIYRSE-HLKLPP--------------GNCGFE--HS 180

  Fly   346 KYTKEANFAEGAFYDPSTGRRLGSSANVADWH-QLVHE---RVRRATDNGAGDRGSSGGSGRGRE 406
            :.|.:                        ||. |..|:   :.||..                ||
  Rat   181 RPTSK------------------------DWTLQFTHQTKKQPRRMK----------------RE 205

  Fly   407 D--NKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKF 469
            |  :.....||:             :||:...:|...|:...:.....||::   |:..||:.
  Rat   206 DLHSMKYVELYL-------------VADYAEFQKNRHDQDATKHKLMEIANY---VDKFYRSL-- 252

  Fly   470 DGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFC----NEHMDVSNFLN----LHSLEDHSDF 526
                   :||..:..:::           ..|...|    |.:..:.:||:    |.:.:.|.:
  Rat   253 -------SIRIALVGLEV-----------WTHGDKCEVSENPYSTLWSFLSWRRKLLTQKSHDN- 298

  Fly   527 CLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNT-GIITFVNYN 590
              |.:.|.|.|.|.|:|||.:.:       :|..|::     ||  .|...|.|. |:.:
  Rat   299 --AQLITGRSFQGTTIGLAPLMA-------MCSVYQS-----GG--VSMDHSENAIGVAS----- 342

  Fly   591 SRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNIS 655
                      |:|||||||||..||....|.....:|..|| |:||.  .|....||.|:.:.:.
  Rat   343 ----------TVAHEIGHNFGMSHDSAHCCSTSAADGGCIM-AAATG--HPFPKVFSSCNRKELD 394

  Fly   656 NVLDVLVG---NTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNS 717
            ..|....|   :...|......|..|||..:|.||||||| .|:|||:.||
  Rat   395 RYLQSGGGMCLSNMPDTRTLYGGRRCGNGYLEDGEECDCG-EEDECKNPCC-------------- 444

  Fly   718 SAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEET-ECSWSSTCNGTTAECPEPRHRDD 781
            :|..||.:...:|  :.|.||  :.|..|...  .:|:|:. :|.....|.|.:..||...::.|
  Rat   445 NASNCTLKEGAEC--AHGSCC--HQCKLVAPG--TQCREQVRQCDLPEFCTGKSPHCPTNYYQMD 503

  Fly   782 KTMCNNGTALCIRGEC--SGSPC-LLWN------MTKCF----LTSTTLPHVSK----------- 822
            .|.|..|.|.|..|.|  ....| .||.      :..||    ....|..:..|
  Rat   504 GTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPALDLCFERVNAAGDTYGNCGKGLNGKYRKCSP 568

  Fly   823 --RKLCDLACQ-------DGN----DTST--------CRSTSEFADKYNIQKGGISLQP-----G 861
              .|...:.||       :.|    ||:.        ||.|..:......:..|..|.|     |
  Rat   569 RDAKCGKIQCQSTQARPLESNAVSIDTTITLNGRRIHCRGTHVYRGPEEEEGEGDMLDPGLVMTG 633

  Fly   862 SPCDN----FQGYC--DVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEWI------------VD 908
            :.|.:    |:|.|  ..|.:   .:..|.......:..|.|.......|.            :|
  Rat   634 TKCGHNHICFEGQCRNTSFFE---TEGCGKKCNGHGVCNNNKNCHCFPGWAPPFCNTPGDGGSID 695

  Fly   909 NWYL------VVLMGV-AFIVVMGSFIKCCAVH-------TPSSNPKKRRAR-----RISET--- 951
            :..|      .|:.|| :.:.|:...:..|..:       .||:.|.|.|.:     |:|:.
  Rat   696 SGPLPPKSAGPVIAGVFSALFVLAVLVLLCHCYRQSHKLGKPSALPFKLRQQFSCPFRVSQNGGT 760

  Fly   952 --------LRAPM---------NTLRRMQRHPNQRGAGPRSIPPPAHEAQHYSRGGDGRGGGGGG 999
                    |:.|.         .|||:....|      ||  |||     .|.|
  Rat   761 GHANPTFKLQTPQGKRKVTNTPETLRKPSHPP------PR--PPP-----DYLR----------- 801

  Fly  1000 GGRHGGSRSHHQQHPHDWDRHQGGHSIVPLP---TGGSHSSRNSAANQARRSDGRGPRSTSSGRP 1061
                      .:.||            .|||   ...:.||..:.|...|:...|.|   ...||
  Rat   802 ----------VESHP------------APLPAHLNRAAGSSPEAGAQIERKESARRP---PPSRP 841

  Fly  1062 QAIASGSGAASGAARSHGGYGAEQAIPGSIGGGVQAAISSGGVVARAQLPLPLPPPNGQQQMQQQ 1126
            ...|.....:...:|..   ..::|:|.:...|.:.....||.      .|..||..|.|..
  Rat   842 MPPAPNCLLSQDFSRPR---PPQKALPANPVPGQRTVPRPGGT------SLFHPPTTGPQPP--- 894

  Fly  1127 QQLQLQQPAISPQQQPQ 1143
                 :.||:|..:.|:
  Rat   895 -----RPPAVSVPKLPE 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	64/278 (23%)
		Reprolysin_2	450..659	CDD:290307	54/217 (25%)
		Disintegrin	684..776	CDD:278623	30/92 (33%)
Adam19	NP_001153700.1	Pep_M12B_propep	62..162	CDD:279848	21/93 (23%)
		Reprolysin	211..409	CDD:279729	62/268 (23%)
		ZnMc_adamalysin_II_like	211..407	CDD:239797	62/266 (23%)
		DISIN	440..500	CDD:214490	19/79 (24%)
		ACR	502..650	CDD:214743	32/147 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920