DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam23

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_001025070.2	Gene:	Adam23 / 301460	RGDID:	1305739	Length:	828	Species:	Rattus norvegicus

Alignment Length:	843	Identity:	186/843 - (22%)
Similarity:	275/843 - (32%)	Gaps:	298/843 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 TRPLAKSNTSTTAV--NSKTENFIKKIAESTTTSQQLPEYTESSSSST---TTFPPTTEYFEDEK 243
            :||.|:...:.:|:  |...||....:|:..:|.||......|.||:.   .|.|....|:
  Rat    56 SRPRARGAAALSALHWNETAENSPGVVADEDSTLQQNGSRNTSYSSAVQKEITLPSRLVYY---- 116

  Fly   244 ERNAEDELDFHSIIYKESHVEDAYENVREGHVAGCGITDEV--SQW-MENIQNSAVEELPEPMSK 305
             .|.:.|..:|.:..|..|.:...:.|   |:|......|.  |:: ::.|.|:.:      :|.
  Rat   117 -INQDSESPYHVLDTKARHQQKHNKAV---HLAQASFQIEAFGSKFILDLILNNGL------LSS 171

  Fly   306 DYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSS 370
            ||.::|.                         ||.|   |.|:|.   .|..:|.       ||.
  Rat   172 DYVEIHY-------------------------EDGK---QMYSKG---GEHCYYH-------GSI 198

  Fly   371 ANVADWHQLVHERVRRATDNG-------------------AGDRGSSGG--------SGRGREDN 408
            ..|.|      .||..:|.||                   ..|..|:|.        :|:..:..
  Rat   199 RGVKD------SRVALSTCNGLHGMFEDDTFVYMIEPLELTHDEKSTGRPHIIQKTLAGQYSKQM 257

  Fly   409 KNTCSLYIQTD-----PLI----WRHIREGIADHDRG----RKY-EV----DEKTREEITSLIAH 455
            ||     :.||     ||:    |...|:...:..||    .|| |:    |.||.::..|..||
  Rat   258 KN-----LSTDGSDQWPLLPELQWLRRRKRAVNPSRGVFEEMKYLELMIVNDHKTYKKHRSSHAH 317

  Fly   456 H-------VTAVNYIYR---NTK-----FDGRTEHRNIRFEV-------------QRIKIDDDSA 492
            .       |..|:.||:   ||:     .:..||...|...:             ||||
  Rat   318 TNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITINPVQMLHEFSKYRQRIK------ 376

  Fly   493 CRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGI 557
                          :|.|..:.::            ...|.|:            .|:....||:
  Rat   377 --------------QHADAVHLIS------------RVTFHYK------------RSSLSYFGGV 403

  Fly   558 CEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFG---SPHDYPQE 619
            |.:.|                 ..|:..:     .:|..|:|: |:..:..|.|   .|.....:
  Rat   404 CSRVK-----------------GVGVNEY-----GLPMAVAQV-LSQSLAQNLGIQWEPSSRKPK 445

  Fly   620 CRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLD----VLVGNTKRDCFKASEGAFCGN 680
            |......|..||..:..|..|    |||.|||....:.|.    ..:.|.....|:.:|   |||
  Rat   446 CECIESWGGCIMEETGVSHSR----KFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTE---CGN 503

  Fly   681 KIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTF 745
            ..||:||||||||: .||...||                |.|:......|  |.||||.:.||.|
  Rat   504 GYVEAGEECDCGFH-VECYGVCC----------------KKCSLSNGAHC--SDGPCCNNTSCLF 549

  Fly   746 VPTSYHQKCKEE-TECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECS--GSPC-LLWN 806
            ....|  :|::. ..|..:..|.|.:.:||...|:.|...||.....|..|||.  .:.| .:|.
  Rat   550 QSRGY--ECRDAVNSCDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWG 612

  Fly   807 MTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTCRSTSEFADKYNIQKGGISLQPGSPCDNFQGYC 871
                          :|....|..|.:       :..:|..:|.|..|.|
  Rat   613 --------------TKASGSDKFCYE-------KLNTEGTEKGNCGKDG---------------- 640

  Fly   872 DVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAVH 934
            |.:::|...|.....|...||....:..|...|.|..::|           ..|..|.|...|
  Rat   641 DRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFY-----------HQGRVIDCSGAH 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	64/319 (20%)
		Reprolysin_2	450..659	CDD:290307	45/239 (19%)
		Disintegrin	684..776	CDD:278623	31/92 (34%)
Adam23	NP_001025070.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339792
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850