DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and Adam10

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_062127.1	Gene:	Adam10 / 29650	RGDID:	2032	Length:	749	Species:	Rattus norvegicus

Alignment Length:	982	Identity:	342/982 - (34%)
Similarity:	475/982 - (48%)	Gaps:	249/982 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IIIVNGYAKDISGVKRGHERLNEYISHYETLNYDHEHIRASHNRARRSVT-KDQYVHLKFASHGR 80
            :|::..:|..:.| :.|:. ||:||.|||.|:|:.:.:...|.||:|:|: :||::.|.|.:|||
  Rat     7 LILLLSWAAGLGG-QYGNP-LNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLLLDFHAHGR 69

  Fly    81 DFHLRLKRDLNTFSNKLDFYDSKGPIDVSTDHIYEGEVIGDRNSYVFGSIHNGVFEGKIITERDA 145
            .|:||:|||.:.||::.....|...:|..|.|||.|.:.|:..|:..||:.:|.|||.|.|....
  Rat    70 QFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVVDGRFEGFIQTRGGT 134

  Fly   146 YYVEHAKHYFPTNRTATTTPPSTSTTSSATTATKSTQPTRPLAKSNTSTTAVNSKTENFIKKIAE 210
            :|:|.|:.|.
  Rat   135 FYIEPAERYI------------------------------------------------------- 144

  Fly   211 STTTSQQLPEYTESSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYKESHVEDAYENVREGHV 275
                                            |:|    .|.|||:||   |.:|.....:.|..
  Rat   145 --------------------------------KDR----ILPFHSVIY---HEDDINYPHKYGPQ 170

  Fly   276 AGCGITDEVSQWMENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDF 340
            .||. ...|.:.|...|.:.|||.....|:::......:|.:|
  Rat   171 GGCA-DHSVFERMRKYQMTGVEEGTRAHSEEHAASMGPELLRK---------------------- 212

  Fly   341 KYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGR 405
                    |....||
  Rat   213 --------KRTTLAE-------------------------------------------------- 219

  Fly   406 EDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFD 470
               :|||.||||||.|.:::.                 .|||.:.:.|:.||.|::.||:.|.|.
  Rat   220 ---RNTCQLYIQTDHLFFKYY-----------------GTREAVIAQISSHVKAIDTIYQTTDFS 264

  Fly   471 GRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYR 535
            |   .|||.|.|:||:|:..|    ....|.|.|...::.|..||.|:|.::|.|:|||||||.|
  Rat   265 G---IRNISFMVKRIRINTTS----DEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDR 322

  Fly   536 DFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQL 600
            ||..|.||||||.:.||:|||||||.|.|::       ..|:||||||||..||.|.||||||.:
  Rat   323 DFDDGVLGLAWVGAPSGSSGGICEKSKLYSD-------GKKKSLNTGIITVQNYGSHVPPKVSHI 380

  Fly   601 TLAHEIGHNFGSPHDYPQECRPGGL-------NGNYIMFASATSGDRPNNSKFSPCSIRNISNVL 658
            |.|||:|||||||||...||.||..       ||||||:|.|||||:.||:|||.|||||||.||
  Rat   381 TFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVL 445

  Fly   659 DVLVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCT 723
            :    ..:.:||..|....|||.:||.|||||||:: ::|||:||:        .:.....|.|.
  Rat   446 E----KKRNNCFVESGQPICGNGMVEQGEECDCGYS-DQCKDECCF--------DANQPEGKKCK 497

  Fly   724 RRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEETECSWSSTCNGTTAECPEPRHRDDKTMCNNG 788
            .:...||||||||||.: .|.|  .|..:||:::::|:....|||.||.||....:.:.|.||..
  Rat   498 LKPGKQCSPSQGPCCTA-QCAF--KSKSEKCRDDSDCAKEGICNGFTALCPASDPKPNFTDCNRH 559

  Fly   789 TALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTCRSTSEFADKYNIQK 853
            |.:||.|:|:||.|..:::.:|  |..:......::||.:.|......|||.||...  ::|.|.
  Rat   560 TQVCINGQCAGSICEKYDLEEC--TCASSDGKDDKELCHVCCMKKMAPSTCASTGSL--QWNKQF 620

  Fly   854 GG--ISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLM 916
            .|  |:|||||||::|:||||||::||.|||||||.|||..:.:.:..:.:|||||.:|:.|:||
  Rat   621 NGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPQLYENIAEWIVAHWWAVLLM 685

  Fly   917 GVAFIVVMGSFIKCCAVHTPSSNPKKRRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIPPPAH 981
            |:|.|::|..|||.|:|||||||||....:.:..||:      ||....|.|:  .||..|..::
  Rat   686 GIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLK------RRRPPQPIQQ--PPRQRPRESY 742

  Fly   982 EAQHYSR 988
            :..|..|
  Rat   743 QMGHMRR 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	133/273 (49%)
		Reprolysin_2	450..659	CDD:290307	116/215 (54%)
		Disintegrin	684..776	CDD:278623	38/91 (42%)
Adam10	NP_062127.1	Pep_M12B_propep	48..141	CDD:307618	38/92 (41%)
		Cysteine switch	171..178		2/7 (29%)
		ZnMc_TACE_like	221..460	CDD:239798	133/273 (49%)
		DISIN	467..546	CDD:214490	37/90 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	705..749		16/51 (31%)
		SH3-binding. /evidence=ECO:0000255	709..716		2/6 (33%)
		SH3-binding. /evidence=ECO:0000255	723..729		2/5 (40%)
		Interaction with AP2A1, AP2A2 and AP2M1. /evidence=ECO:0000250\|UniProtKB:O35598	735..749		3/13 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339788
Domainoid	1	1.000	214	1.000	Domainoid score	I2658
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	583	1.000	Inparanoid score	I975
OMA	1	1.010	-	-		QHG48710
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0006327
OrthoInspector	1	1.000	-	-		oto95554
orthoMCL	1	0.900	-	-		OOG6_104685
Panther	1	1.100	-	-	LDO	PTHR45702
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3482
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910