Protein Alignment kuz and Adam7

DIOPT Version :9

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_064697.2
• Gene: Adam7 / 29641
• RGDID: 62032
• Length: 789
• Species: Rattus norvegicus
• Alignment Length: 843
• Identity: 171/843 - (20%)
• Similarity: 280/843 - (33%)
• Gaps: 287/843 - (34%)

  Fly   324 QQQPHPPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGS----------SANVAD-WH 377
            |:..||.|..:....|.:..|...|.| .:.|...|:...||:..:          :.|.:: ::
  Rat    27 QELVHPKKLSLLQKRDLERIHDSDTPE-EYEEELLYEIKLGRKTLTLHLLKAREFLALNYSETYY 90

  Fly   378 QLVHERVRR----------------ATDNGAGDRGSSGGSGRGREDNKNTCSLYI--------QT 418
            .:..|.|.|                ..|:.|.....:|..|..|.:::.    |:        :.
  Rat    91 NIKREMVTRHPQILDHCFYQGSIIHEFDSAASISTCNGLRGFFRVNDQR----YLIEPVKYSDEG 151

  Fly   419 DPLIWRH------------------IREGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIY- 464
            |.|::::                  .:..:.|.....:::|::..:|:...|.   |.|..::|
  Rat   152 DHLVFKYNVKAPYATNYSCEGLNFTKKSTLIDAKNIEEHKVEDYHKEKFIELF---VVADEFVYR 213

  Fly   465 RNTKFDGRTEHR--------NIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHS-- 519
            ||:|...:...|        |:.::...|::        :..|.......:.:::.:  ||.|
  Rat   214 RNSKPQNKLRKRIWGMVNFVNMIYKALNIRV--------TLTGMEIWSAGDEIEIVS--NLESTL 268

  Fly   520 ----------LEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQS 574
                      |:...||....:.:.:.......|:|:       .||||:
  Rat   269 LHFSTWQETVLKKRKDFDHVILLSGKWLYTSMQGIAY-------PGGICQ--------------- 311

  Fly   575 TKRSLNT--GIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPH-DYPQECRPGGLNGNYIMFASAT 636
            |.||.:.  .::..||        :....:||::||:.|..| |:|..|.    .|..:|.|.:.
  Rat   312 TLRSCSVVKDLLPDVN--------IIGNRMAHQLGHSLGMRHDDFPCTCP----LGKCVMGAGSI 364

  Fly   637 SGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCF-------KASEGAFCGNKIVESGEECDCGFN 694
            ..     .|||.||.......|.    |.|..|.       :.::..|||||.|:.||||||| .
  Rat   365 PA-----IKFSKCSQTQYQQFLK----NQKPACILNNPLPEEFNDYPFCGNKKVDEGEECDCG-P 419

  Fly   695 EEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKE--- 756
            .:||.:.||              .|..|..:....|  .:|.||  .||        |..||
  Rat   420 VQECTNPCC--------------DAHKCVLKPGFTC--VEGECC--ESC--------QMKKEGVI 458

  Fly   757 ----ETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGEC-----------SG----SPC 802
                :.||..|..|.|.:.|||:...:.:...|.||...|..|.|           ||    |..
  Rat   459 CRPAKNECDISEVCTGYSPECPKDESQANGFPCKNGEGYCFMGLCPTRDDQCAELFSGGAEESHS 523

  Fly   803 LLWNMTK-------CFLTSTTLPHVSKRKLCDLACQDGNDTSTCRSTSEFADK-YNIQ--KGGIS 857
            |.:.|.:       |.....|.....::   ||.|.....|...||.....|| ||::  |..||
  Rat   524 LCYRMNQKGNRFGYCKNKDNTFVPCEEK---DLKCGKIYCTGGRRSAHLGEDKTYNLKNVKQNIS 585

  Fly   858 LQ-----------------------PGSPCDNFQGYCDVFLK----------CRAVDAD------ 883
            ::                       .|..|.|  |.|....|          |...|.|
  Rat   586 IKCKTMFLYHNSRDMGLVNSGTKCGEGMVCSN--GECIEMEKAYNSTICSSLCDENDVDDNEPDC 648

  Fly   884 ----GPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAVHTPSSNPKKRR 944
                ||::......||..::..:...:|     :|::||..::::..:.||..:....|:  .|.
  Rat   649 QCEEGPIITEWGEALNLTSVSIMVVVLV-----MVIIGVGLVILLIRYQKCIKMKQVQSS--SRE 706

  Fly   945 ARRIS---------ETLRAPM--------NTLRRMQRHPNQRGA-----------GPRSIPPP 979
            .|.|.         :|...|:        ||...::|.|:...:           .||.|..|
  Rat   707 IRGIENKVYFPDEHQTRSEPIFTDIYPLHNTAESLERVPSTFSSPHYITLKSVSKDPRGIADP 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	55/323 (17%)
		Reprolysin_2	450..659	CDD:290307	45/232 (19%)
		Disintegrin	684..776	CDD:278623	30/98 (31%)
Adam7	NP_064697.2	Pep_M12B_propep	28..156	CDD:396235	23/132 (17%)
		Reprolysin	199..393	CDD:396140	49/249 (20%)
		DISIN	410..482	CDD:214490	30/98 (31%)
		ACR	486..623	CDD:214743	31/141 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	762..789		4/8 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339785
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850