DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam24

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_017455860.1	Gene:	Adam24 / 290774	RGDID:	1309066	Length:	740	Species:	Rattus norvegicus

Alignment Length:	307	Identity:	88/307 - (28%)
Similarity:	121/307 - (39%)	Gaps:	86/307 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 AFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTET 567
            |||     :...:|.:|   ...:.:|::|....| |...|:|:|       |.:|.|      |
  Rat   278 AFC-----LWKTMNFNS---QMAYDIAHLFVNYTF-GDYFGIAFV-------GTVCNK------T 320

  Fly   568 VGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGLNGNYIMF 632
            .|   ....|......:|..:            .:|||||||.|.||| ...|..|  .|..:|.
  Rat   321 FG---CGVDRLFGDNFLTIGH------------IVAHEIGHNLGMPHD-GILCSCG--EGPCLMS 367

  Fly   633 ASATSGDRPNNSKFSPCSIRNI-SNVLDVLVGNTKRDCFK---ASEGAF----CGNKIVESGEEC 689
            |:..|     :.|.|.||...: :|:       .|:.|.:   :|...|    |||.:|:.||||
  Rat   368 ATMES-----SKKLSNCSYEFLWANI-------AKKSCLQREPSSSDIFPMKICGNGVVDDGEEC 420

  Fly   690 DCGFNEEEC--KDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQ 752
            |||  .:.|  ..:||.|..|      |.|.||         |  :.|.|| :..|...|:.  .
  Rat   421 DCG--SQSCGRNSRCCLPTCI------LKSGAK---------C--ASGLCC-NFKCQIQPSG--T 463

  Fly   753 KCK-EETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECS 798
            .|: :|.||.....||||:.||||.......|.| .|...|....|:
  Rat   464 LCRTKENECDLPEWCNGTSKECPEDTFVQAGTSC-LGNGYCYEKRCN 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	44/177 (25%)
		Reprolysin_2	450..659	CDD:290307	41/156 (26%)
		Disintegrin	684..776	CDD:278623	33/94 (35%)
Adam24	XP_017455860.1	Pep_M12B_propep	42..160	CDD:396235
		ZnMc_adamalysin_II_like	209..395	CDD:239797	43/168 (26%)
		DISIN	415..490	CDD:214490	34/96 (35%)
		ACR	492..628	CDD:214743	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339800
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850