DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam1a

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_742124.2	Gene:	Adam1a / 280668	MGIID:	2429504	Length:	791	Species:	Mus musculus

Alignment Length:	461	Identity:	106/461 - (22%)
Similarity:	149/461 - (32%)	Gaps:	174/461 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   602 LAHEIGHNFGSPHDYPQ-ECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLD-----V 660
            :|||:|||.|..||:|. .|.|    .::.:.......|    |.||.||..:....|.     .
Mouse   368 MAHELGHNLGIQHDHPTCTCGP----KHFCLMGEKIGKD----SGFSNCSSDHFLRFLHDHRGAC 424

  Fly   661 LVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEEC-KDKCCYPRLISEYDQSLNSSAKGCTR 724
            |:....|.. :....|.|||.:||..||||||   .:| ...||.|.               ||.
Mouse   425 LLDEPGRQS-RMRRAANCGNGVVEDLEECDCG---SDCDSHPCCSPT---------------CTL 470

  Fly   725 RAKTQCSPSQGPCCLSNSCTFVPTSYHQKCK-EETECSWSSTCNGTTAECPEPRHRDDKTMCNNG 788
            :...||  |:|.||.  :|||....  ..|: .|..|.....|:|:|.|||...:..|.|.|:.
Mouse   471 KEGAQC--SEGLCCY--NCTFKKKG--SLCRPAEDVCDLPEYCDGSTQECPANSYMQDGTQCDR- 528

  Fly   789 TALCIRGECS----------GSPCLLWNMTKCFLTSTTLPHVSKRKLCDLACQDGNDTS------ 837
            ...|:.|.|.          |.|... ...:|:::..|  ..::...|      |:.||
Mouse   529 IYYCLGGWCKNPDKQCSRIYGYPARS-APEECYISVNT--KANRFGNC------GHPTSANFRYE 584

  Fly   838 TCRSTSEFA---------------------------------DKYNIQ--------KGGISLQPG 861
            ||.....|.                                 |.|||.        :.|....|.
Mouse   585 TCSDEDVFCGKLVCTDVRYLPKVKPLHSLLQVPYGEDWCWSMDAYNITDVPDDGDVQSGTFCAPN 649

  Fly   862 SPCDNF--------------------QGYCDVFLKCR-----------------AVDADGPLLRL 889
            ..|..:                    .|.|:.|..|.                 :||: ||:.:.
Mouse   650 KVCMEYICTGRGVLQYNCEPQEMCHGNGVCNNFKHCHCDAGFAPPDCSSPGNGGSVDS-GPVGKP 713

  Fly   890 KNLLLNRKTLQTVAEWIVD--------NWYLVVLMGVAFIVVMGSFIKCC-------------AV 933
            .:..|   :|..:||...|        |..::||:...|:||    :.||             .|
Mouse   714 ADRHL---SLSFLAEESPDDKMEDEEVNLKVMVLVVPIFLVV----LLCCLMLIAYLWSEVQEVV 771

  Fly   934 HTPSSN 939
            ..|||:
Mouse   772 SPPSSS 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	21/80 (26%)
		Reprolysin_2	450..659	CDD:290307	18/57 (32%)
		Disintegrin	684..776	CDD:278623	31/93 (33%)
Adam1a	NP_742124.2	Pep_M12B_propep	95..190	CDD:279848
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..220
		Reprolysin	235..429	CDD:279729	20/68 (29%)
		ZnMc_adamalysin_II_like	235..427	CDD:239797	20/66 (30%)
		DISIN	447..519	CDD:214490	31/95 (33%)
		ACR	521..657	CDD:214743	24/145 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	772..791		3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836118
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850