DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam1b

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_742123.2	Gene:	Adam1b / 280667	MGIID:	2429506	Length:	806	Species:	Mus musculus

Alignment Length:	377	Identity:	97/377 - (25%)
Similarity:	134/377 - (35%)	Gaps:	116/377 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   602 LAHEIGHNFGSPHDYPQ-ECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLD-----V 660
            :|||:|||.|..||:|. .|.|    .::.:.......|    |.||.||..:....|.     .
Mouse   336 MAHELGHNLGIQHDHPTCTCGP----KHFCLMGEKIGKD----SGFSNCSSDHFLRFLHDHRGVC 392

  Fly   661 LVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEEC-KDKCCYPRLISEYDQSLNSSAKGCTR 724
            |:....|.. :....|.|||.:||..|:||||   .:| |.:||        |::       |..
Mouse   393 LLDEPGRQS-RMRRAANCGNGVVEDLEQCDCG---SDCDKSQCC--------DEN-------CKL 438

  Fly   725 RAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEETE--------CSWSSTCNGTTAECPEPRHRDD 781
            :..:.||...  ||.  .|.|         |:|.:        |.....||||:|.||..|...|
Mouse   439 KGNSVCSTEL--CCF--KCNF---------KKEGDVCRPADGPCDLEEYCNGTSAACPSDRKAQD 490

  Fly   782 KTMCNNGTALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSK--RKLCDLACQD-GNDTSTCRSTS 843
            .:.|:. :.||..|:|         |...|..|....|.|:  ...|..:... |:....|.|:|
Mouse   491 GSKCHE-SFLCFNGQC---------MDPTFQCSRIFGHGSRSASDYCYTSLNSRGDQFGNCGSSS 545

  Fly   844 EFADKYNIQKGGISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLLLN------------- 895
            :|..||            :.|.:....|...: |..| |..|.::..||||.
Mouse   546 QFPKKY------------TKCSDKNVMCGKLI-CTEV-AFLPQIQPNNLLLQVPETEDWCWSVAV 596

  Fly   896 ---RKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKC----CAVHTPSSNP 940
               |.:|.  .|::.||.|            .|....|    |...||.|.|
Mouse   597 FDMRDSLH--EEYVKDNTY------------CGKDKVCKNSICEDFTPFSFP 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	21/80 (26%)
		Reprolysin_2	450..659	CDD:290307	18/57 (32%)
		Disintegrin	684..776	CDD:278623	28/100 (28%)
Adam1b	NP_742123.2	Pep_M12B_propep	63..158	CDD:279848
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..188
		Reprolysin	203..397	CDD:279729	20/68 (29%)
		ZnMc_adamalysin_II_like	203..395	CDD:239797	20/66 (30%)
		Disintegrin	415..485	CDD:278623	28/100 (28%)
		ACR	489..625	CDD:214743	37/173 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..694
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..806
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836119
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940