DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and ADAM2

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_001455.3	Gene:	ADAM2 / 2515	HGNCID:	198	Length:	735	Species:	Homo sapiens

Alignment Length:	262	Identity:	68/262 - (25%)
Similarity:	103/262 - (39%)	Gaps:	68/262 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   561 YKTYTETVGGQYQSTKRSLNTGIITFVNYNSRV---PPKVS----QLTLAHEIGHNFGSPHDYPQ 618
            |:..:..||..:|        |.:...||...|   |..:|    .:.||..:..:.|..:|...
Human   271 YREKSNYVGATFQ--------GKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDIN 327

  Fly   619 ECRPGG----LNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDC---------- 669
            :|:..|    :|...|.|:..        ..||.||..:.::    .:...|..|
Human   328 KCQCSGAVCIMNPEAIHFSGV--------KIFSNCSFEDFAH----FISKQKSQCLHNQPRLDPF 380

  Fly   670 FKASEGAFCGNKIVESGEECDCGFNEEECK---DKCCYPRLISEYDQSLNSSAKGCTRRAKTQCS 731
            ||  :.|.|||..:|:||||||| .|::|.   :.||              ....|..:|.:.|
Human   381 FK--QQAVCGNAKLEAGEECDCG-TEQDCALIGETCC--------------DIATCRFKAGSNC- 427

  Fly   732 PSQGPCCLSNSCTFVPTSYHQKCKEE-TECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRG 795
             ::||||  .:|.|:  |..:.|:.. .||.....|||::|.|||..:......|.....:||.|
Human   428 -AEGPCC--ENCLFM--SKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDG 487

  Fly   796 EC 797
            .|
Human   488 VC 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	27/136 (20%)
		Reprolysin_2	450..659	CDD:290307	23/108 (21%)
		Disintegrin	684..776	CDD:278623	31/95 (33%)
ADAM2	NP_001455.3	Pep_M12B_propep	42..140	CDD:279848
		Reprolysin	178..375	CDD:279729	25/123 (20%)
		ZnMc_adamalysin_II_like	178..373	CDD:239797	25/121 (21%)
		DISIN	393..470	CDD:214490	32/97 (33%)
		ACR	472..609	CDD:214743	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146054
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850