Protein Alignment kuz and Adam6a

DIOPT Version :9

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_777479.2
• Gene: Adam6a / 238406
• MGIID: 2676316
• Length: 754
• Species: Mus musculus
• Alignment Length: 623
• Identity: 129/623 - (20%)
• Similarity: 213/623 - (34%)
• Gaps: 196/623 - (31%)

  Fly   418 TDPL-IWRHIREGIADHDRGRKY-----EVDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHR 476
            |.|: .|:|............:|     .:..|......:.|..|..|.:.:|..:..|..:...
Mouse   176 TGPMNAWKHWSHNTGSPSSRLEYADGAPRLSSKNYATHPAAIKGHFQATHSVYSASGGDKLSSTV 240

  Fly   477 NIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFL-NLHSLED--HSDFCL----AYVFTY 534
            ...|:|  |.:.|      :|      ..|.||....|| .:::..|  ..||.:    |:.|..
Mouse   241 EYLFKV--ISLMD------TY------LTNLHMRYYVFLMTVYTEADPFSQDFRVPGGQAHTFYE 291

  Fly   535 RDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSL-NTGIITFVNYNSRVPPKVS 598
            |.|         .|.....:|.|..|.....:.|    ...:||: :...:..:..:.|.|..:|
Mouse   292 RVF---------YAHFRPDAGAIINKNSPGDDAV----NPAERSICSPSALICLGQHGRNPLFLS 343

  Fly   599 QLTLAHEIGHNFGSPHDYPQE----CRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLD 659
             :.:.:.:|.:.|..||   |    |:   .....|||.:....|     .||.||:..|||:|:
Mouse   344 -IIITNRVGRSLGLKHD---EGYCICQ---RRNTCIMFKNPQLTD-----AFSNCSLAEISNILN 396

  Fly   660 V------------LVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYD 712
            .            :..||.. .:|     ||||..|::.|:||||..:....|.||
Mouse   397 TPDLMPCLFYDRHVYYNTSL-TYK-----FCGNFKVDNNEQCDCGSQKACYSDPCC--------- 446

  Fly   713 QSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKE-ETECSWSSTCNGTTAECPEP 776
                  ...|.....:.|....  ||.  :||:.|:.  ..|:. :..|.....|:|:...||:.
Mouse   447 ------GNDCRLTPGSICDKEL--CCA--NCTYSPSG--TLCRPIQNICDLPEYCSGSKFICPDD 499

  Fly   777 RHRDDKTMCNNGTALCIRGECS--GSPCL-LWNMT------KCF------------------LT- 813
            .:..|.|.|:. ...|.:|.|:  ...|: ::.::      ||:                  ||
Mouse   500 TYLQDGTPCSE-EGYCYKGNCTDRNIQCMEIFGVSAKNANIKCYDINKQRFRFGHCTRAEESLTF 563

  Fly   814 -----------------STTLP----HVS--KRKLCDLAC-----QDGNDTS--------TCRST 842
                             .|.||    |||  :..:..:.|     ..|.:|:        |..|.
Mouse   564 NACADQDKLCGRLQCTNVTNLPFLQEHVSFHQSVISGVTCFGLDEHRGTETADAGLVRHGTPCSR 628

  Fly   843 SEFADKYNIQKGGISLQPGSPCD----NFQGYCDVFLKCR-----------------AVDADGPL 886
            .:|.|: ....|.:| :.|..|.    ||:|.|:....|.                 ::|:..|.
Mouse   629 GKFCDR-GACNGSLS-RLGYDCTPEKCNFRGVCNNRRNCHCHFGWSPPKCKEEGHSGSIDSGSPP 691

  Fly   887 LRLKNLLLNRKTLQTVAEWIVDNWYLVVLMG-VAFIVV 923
            ::       |:.::...|.:|   ||.:|.| :.|:.|
Mouse   692 VQ-------RRIIKQNLEPVV---YLRILFGRIYFLFV 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	59/288 (20%)
		Reprolysin_2	450..659	CDD:290307	49/220 (22%)
		Disintegrin	684..776	CDD:278623	21/92 (23%)
Adam6a	NP_777479.2	Pep_M12B_propep	69..166	CDD:279848
		ZnMc_adamalysin_II_like	217..406	CDD:239797	50/227 (22%)
		Disintegrin	427..500	CDD:278623	21/93 (23%)
		ACR	503..638	CDD:214743	24/136 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836122
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850