DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and Adam25

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_035911.2	Gene:	Adam25 / 23793	MGIID:	1345157	Length:	760	Species:	Mus musculus

Alignment Length:	727	Identity:	145/727 - (19%)
Similarity:	222/727 - (30%)	Gaps:	271/727 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   415 YIQTDPLIWRHIR----------------EGIADHDRGRKYEVD------------EKTREEITS 451
            |:|.|.....|:.                :||...: |..||:.            :|...|.|.
Mouse   119 YVQNDCYYHGHMDGDPESMVAITTCYGGFQGILQIN-GTVYEIKPKNLSSTFEHLVQKMDSEETE 182

  Fly   452 LIAHHVTAVNYIYRNTK-------------FDGRTEHRN-----IRFEVQRIKIDDDSACR---- 494
            |:.........|.|..|             ::|...|::     :..|.:||:..:::..|
Mouse   183 LLPMRCALTEEIARQMKLQQNENPTLMQSHYEGWWTHKSFLDLALVVERERIRYHNNNTSRVLVE 247

  Fly   495 --NSYNGPHNAFCNEHMDVS------------NFLNLHSLEDHSD-FC--------------LAY 530
              ...|..:|.:  |.:||.            |.:.:.|:|:..| ||              :|:
Mouse   248 VFTIINIINNIY--ETLDVELVLLGVEMWNERNHVQVRSIEELLDEFCMWKARSLNFRIPNDIAH 310

  Fly   531 VFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVN----YNS 591
            :|...:| |..||||::       |.:|..                 |.|.|:...:.    |..
Mouse   311 IFVNHEF-GIYLGLAYI-------GSVCVP-----------------SHNCGVDRLLGGNLFYFG 350

  Fly   592 RVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCS------ 650
            |:        :|||:|||.|..|| ...|..|   ....:.|.|.:|    ..|||.||
Mouse   351 RI--------IAHEMGHNLGMEHD-SSSCTCG---RKICLMAPADNG----IPKFSNCSYSYYWA 399

  Fly   651 -------IRNISNVLDVLVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLI 708
                   :|.......:|            .|..||:.:|:.||:||||..:....|.||.|
Mouse   400 TYATAKCMRKEKKSKGIL------------RGKLCGDGVVDDGEQCDCGSAKSCADDPCCKP--- 449

  Fly   709 SEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEE-TECSWSSTCNGTTAE 772
                        .||.:....|  :.|.|||  .|..:|..  ..|::| .||.....|||.:.:
Mouse   450 ------------SCTLKDGAAC--AFGLCCL--YCQIMPAG--TVCRQEVNECDLPEWCNGHSHK 496

  Fly   773 CPEPRHRDDKTMCNNGTALCIRGECSG-------------------------------------- 799
            ||...:..|.:.|.:| ..|....|:.
Mouse   497 CPNDVYLLDGSPCRDG-GYCYEKRCNNRDEQCKQIFGKEARSADHSCYRELNTQGDRFGNCGVIR 560

  Fly   800 -------SPCLLWNMTKC-------FLTSTTLPHVSKRKLCDLAC-----------------QDG 833
                   .|.:|....:|       ||...:..|.:  .|..:.|                 :||
Mouse   561 DAYLRCHDPDILCGRVQCENVAHIPFLRDHSTVHWT--HLNGVTCWGTDYHFGMTIPDIGIVKDG 623

  Fly   834 NDTSTCRSTSEFADKYNIQKGGISLQPGSPCDNFQGYCDVFLKCR-----------------AVD 881
            .|   |.......:|..:.|.....|......|.:|.|:....|.                 ::|
Mouse   624 TD---CGPEHVCINKKCVSKSIWRSQCSPKTCNMKGVCNNLHHCHCNLGWDPPHCLKSGLGGSID 685

  Fly   882 ADGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAVHTPSSNPKKRRAR 946
            : ||....:| ...:|..:::. .::..|.|.....|.|||.:  |.....|..|.|...|....
Mouse   686 S-GPPNYTEN-YTEKKHKKSIG-LVILFWILFACFSVLFIVFL--FFLRSYVELPMSEEPKVPTP 745

  Fly   947 RISETLRAPMNT 958
            ...|.....|||
Mouse   746 ENKEDTNEVMNT 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	70/357 (20%)
		Reprolysin_2	450..659	CDD:290307	57/276 (21%)
		Disintegrin	684..776	CDD:278623	28/92 (30%)
Adam25	NP_035911.2	Pep_M12B_propep	69..173	CDD:279848	9/54 (17%)
		Cysteine switch. /evidence=ECO:0000250	186..193		0/6 (0%)
		ZnMc_adamalysin_II_like	222..399	CDD:239797	49/219 (22%)
		Reprolysin	222..397	CDD:279729	49/217 (23%)
		Disintegrin	428..501	CDD:278623	28/93 (30%)
		ACR	504..640	CDD:214743	18/141 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	738..760		5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920