DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam23

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_035910.1	Gene:	Adam23 / 23792	MGIID:	1345162	Length:	829	Species:	Mus musculus

Alignment Length:	939	Identity:	203/939 - (21%)
Similarity:	310/939 - (33%)	Gaps:	335/939 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 PSTSTTSSATTATKSTQPTRPLAKSNTSTTAV--NSKTENFIKKIAESTTTSQQLPEYTESSSSS 228
            |:.:|:|            ||.|:...:.:|.  |...|..:..:|:...|.||......:|.||
Mouse    50 PALATSS------------RPRARGAAAPSAPHWNETAEKTLGVLADEDNTLQQNSSSRNTSYSS 102

  Fly   229 TT----TFPPTTEYFEDEKERNAEDELDFHSIIYKESHVEDAYENVREGHVAGCGITDEV--SQW 287
            ..    |.|....|:     .|.:.|..:|.:..|..|.:...:.|   |:|......|.  |::
Mouse   103 AVQKEITLPSRLVYY-----INQDSESPYHVLDTKARHQQKHNKAV---HLAQASFQIEAFGSKF 159

  Fly   288 MENIQ-NSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKEA 351
            :.::. |:.:      :|.||.::|.                         ||.|   |.|:|.
Mouse   160 ILDLTLNNGL------LSSDYVEIHY-------------------------EDGK---QMYSKG- 189

  Fly   352 NFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNG-------------------AGDRGS 397
              .|..:|.       ||...|.|      .||..:|.||                   ..|..|
Mouse   190 --GEHCYYH-------GSIRGVKD------SRVALSTCNGLHGMFEDDTFVYMIEPLELTDDEKS 239

  Fly   398 SGG--------SGRGREDNKNTCSLYIQTD-----PLI----WRHIREGIADHDRG----RKY-E 440
            :|.        :|:..:..||     :.||     ||:    |...|:...:..||    .|| |
Mouse   240 TGRPHIIQKTLAGQYSKQMKN-----LSTDGSDQWPLLPELQWLRRRKRAVNPSRGVFEEMKYLE 299

  Fly   441 V----DEKTREEITSLIAHH-------VTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACR 494
            :    |.||.::..|..||.       |..|:.||:        |..|.|..:..::...:
Mouse   300 LMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYK--------EQLNTRVVLVAVETWTE---- 352

  Fly   495 NSYNGPHNAFCNEHMDVSNFLN----LHS-------LEDHSD---FCLAYVFTYRDFTGGTLGLA 545
                       .:|:|::  :|    ||.       ::.|:|   ......|.|:
Mouse   353 -----------KDHIDIT--INPVQMLHDFSKYRQRIKQHADAVHLISRVTFHYK---------- 394

  Fly   546 WVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNF 610
              .|:....||:|.:.:                 ..|:..:     .:|..|:|: |:..:..|.
Mouse   395 --RSSLSYFGGVCSRIR-----------------GVGVNEY-----GLPMAVAQV-LSQSLAQNL 434

  Fly   611 G---SPHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLD----VLVGNTKRD 668
            |   .|.....:|......|..||..:..|..|    |||.|||....:.|.    ..:.|....
Mouse   435 GIQWEPSSRKPKCECIESWGGCIMEETGVSHSR----KFSKCSILEYRDFLQRGGGACLFNRPTK 495

  Fly   669 CFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPS 733
            .|:.:|   |||..||:||||||||: .||...||                |.|:......|  |
Mouse   496 LFEPTE---CGNGYVEAGEECDCGFH-VECYGVCC----------------KKCSLSNGAHC--S 538

  Fly   734 QGPCCLSNSCTFVPTSYHQKCKEE-TECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGEC 797
            .||||.:.||.|....|  :|::. ..|..:..|.|.:.:||...|:.|...||.....|..|||
Mouse   539 DGPCCNNTSCLFQSRGY--ECRDAVNSCDITEYCTGDSGQCPPNLHKQDGYSCNQNQGRCYNGEC 601

  Fly   798 S--GSPC-LLWNMTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTCRSTSEFADKYNIQKGGISLQ 859
            .  .:.| .:|.              :|....|..|.:       :..:|..:|.|..|.|   .
Mouse   602 KTRDNQCQYIWG--------------TKAAGSDKFCYE-------KLNTEGTEKGNCGKDG---D 642

  Fly   860 PGSPCDNFQGYCDVFLKC-------------------------RAVDADGPLLRLKN-------- 891
            ...||.....:|. ||.|                         |.:|..|..:.|.:
Mouse   643 RWIPCSKHDVFCG-FLLCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVE 706

  Fly   892 ---------LLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAVHTPSSNPKKRRARR 947
                     :.|:||.||..|          :.|....:...|   |.|:.|...||    .|..
Mouse   707 DGTPCGPSMMCLDRKCLQIQA----------LNMSSCPLDSRG---KVCSGHGVCSN----EATC 754

  Fly   948 ISETLRAPMN-TLRRMQRHPN-QRGAGPR 974
            |.:...|..: ::|...|:|| .:..||:
Mouse   755 ICDFTWAGTDCSIRDPVRNPNPPKDEGPK 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	62/312 (20%)
		Reprolysin_2	450..659	CDD:290307	43/232 (19%)
		Disintegrin	684..776	CDD:278623	31/92 (34%)
Adam23	NP_035910.1	Pep_M12B_propep	144..246	CDD:279848	29/151 (19%)
		Reprolysin	296..493	CDD:279729	51/260 (20%)
		ZnMc_adamalysin_II_like	296..491	CDD:239797	50/258 (19%)
		Disintegrin	508..581	CDD:278623	31/93 (33%)
		ACR	584..723	CDD:214743	30/163 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836126
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850