Protein Alignment kuz and Gm4787

DIOPT Version :9

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_001034084.2
• Gene: Gm4787 / 214321
• MGIID: 3646380
• Length: 748
• Species: Mus musculus
• Alignment Length: 816
• Identity: 164/816 - (20%)
• Similarity: 251/816 - (30%)
• Gaps: 306/816 - (37%)

  Fly   298 ELPEPMSKDYQKLH----------RKQLHKKSAPQQQQQPHPPKKYISGDE-----DFKY-PHQK 346
            ::|:.|.|.....|          |..:|.|.......|..|  .|.|.|:     |:.: |...
Mouse    52 KVPQRMGKSDMSGHITYSMRFRGQRHVVHMKLKKNMIPQNFP--VYTSNDQGAQQKDYPFVPRDC 114

  Fly   347 YTKEANFAEG-----AFYDPSTG---------------RRLGSSANVADWHQL--VHERVRR--- 386
            |.  .::.||     |..|..||               :.|.||:.......|  |.||.|.
Mouse   115 YF--YSYLEGVPGSQATLDTCTGGLKGMIQVDDFTYEIKPLASSSKFEHVISLLVVDERSRESKK 177

  Fly   387 -------ATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEK 444
                   |......:.....||.|       ...:|      :||:..:.:     |.:|.|
Mouse   178 CRNDEIMAKVGNLPEETKLAGSPR-------AAPVY------LWRYHSKNV-----GIQYTV--- 221

  Fly   445 TREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHM 509
            |.|..|.:.::...::..|...|.........:..|...|      :||  .:|.      .:|.
Mouse   222 THELYTQIGSNSTASIELILIMTSISHSIYKTSGMFVFAR------AAC--IWND------KDHY 272

  Fly   510 DVSNFL-NLHSLEDHSDFCLAYVFTYRD------FTGGTLGLAWVASASGASGGICEKYKTYTET 567
            .:|:|. |:..|.:...:..|..|.:.:      ..|..||   ....:|...|||..
Mouse   273 SISSFYNNVWRLMELFGYWKAGYFWHMEHATTALLLGRKLG---NTDYAGFQDGICNP------- 327

  Fly   568 VGGQYQSTKRSLNTGII-TFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYP-------QECRPGG 624
                        |.|:: |:|..|...   ::...|||.:||.....||.|       ..|
Mouse   328 ------------NWGVLYTYVGTNHFF---LAGSFLAHAVGHLLNVRHDTPGCVCFRRSSC---- 373

  Fly   625 LNGNYIMFASATSGDRPNNSK----------FSPC--SIRNISNVLDVLVGNTKRDCFKASEGAF 677
                 :|....|..|..:|..          :.||  .:|...|:.:|               ..
Mouse   374 -----LMDEFPTLQDMISNCSHDVLHMRIHGWDPCMSEVRRTHNIQNV---------------PR 418

  Fly   678 CGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNS 742
            |||||||..|.||||..::...||||      |.|         |.....:.|  ::|.|||  |
Mouse   419 CGNKIVEGSESCDCGSVKDCTTDKCC------EVD---------CEFTQGSSC--NKGGCCL--S 464

  Fly   743 CTFVPTSYHQKCKEETE-CSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECS-------- 798
            |.|.||.  ..|:::.. |.....|:|.:..||...:..|.|.| :..|:||.|.|:
Mouse   465 CKFAPTG--TICRDKNGICDLPEYCSGASEHCPGNFYIMDGTPC-SPLAVCIAGNCTDRHLQCQA 526

  Fly   799 --------GSPCLLWNMT-------KCFLT-----STTLPHVSKRKLCDLACQD-------GNDT 836
                    .||.....:.       .|.:.     |.|:|...:...|.:...|       |.:.
Mouse   527 LFGYQVKDSSPACYHELNVKGDRFGNCGVRIKRGGSQTVPCQKEDVFCGMLHCDGVKRIVGGGEH 591

  Fly   837 ST--------CRSTSEFADKYNIQKG-----------GISLQPGSPCD----------------- 865
            :|        .:....|.  |:|..|           |.:..||..|.
Mouse   592 TTFYHLKVQDVKEVQCFG--YDIHHGLDLPEIGLVMDGATCGPGKYCKNQRCVFHQTLKFNCNIS 654

  Fly   866 --NFQGYCDVFLKCRAVDA--------------------DGPLLRLK---NLLLNRKTLQTVAEW 905
              ||:|.|:....|..|..                    ..||.|.:   ::.:|:
Mouse   655 SCNFRGVCNNQGNCHCVQGWQPPKCLQRGKGGSVNSGPITNPLKRYRAKIHVSINK--------- 710

  Fly   906 IVDNWYLVVLMG-----VAFIVVMGSFIKCCAVHTP 936
                  |::::|     :..:::.|:..|  ||..|
Mouse   711 ------LLIILGARIFLIVALIIFGALAK--AVLRP 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	53/293 (18%)
		Reprolysin_2	450..659	CDD:290307	44/235 (19%)
		Disintegrin	684..776	CDD:278623	29/92 (32%)
Gm4787	NP_001034084.2	Pep_M12B_propep	60..163	CDD:279848	21/106 (20%)
		ZnMc_adamalysin_II_like	213..405	CDD:239797	47/247 (19%)
		Disintegrin	425..498	CDD:278623	29/93 (31%)
		ACR	501..642	CDD:214743	26/143 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836125
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940