Protein Alignment kuz and ADAM32

DIOPT Version :9

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_659441.4
• Gene: ADAM32 / 203102
• HGNCID: 15479
• Length: 787
• Species: Homo sapiens
• Alignment Length: 759
• Identity: 148/759 - (19%)
• Similarity: 230/759 - (30%)
• Gaps: 283/759 - (37%)

  Fly   513 NFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKR 577
            ::|||...:      :||:..|.|                           |...:|..:
Human   264 SYLNLRPHD------IAYLLIYMD---------------------------YPRYLGAVF----- 290

  Fly   578 SLNTGIITFVNYNSRVPPKVSQLTL-------AHEIGHNFGSPHDYPQECR---------PGGLN 626
               .|.:....|::.|.....::||       ...:..:.|..:|.|::|:         |..:.
Human   291 ---PGTMCITRYSAGVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCIMNPEVVQ 352

  Fly   627 GNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCF-------KASEGAFCGNKIVE 684
            .|.:             ..||.||:|:..|    .:.|....|.       |.|....|||..:|
Human   353 SNGV-------------KTFSSCSLRSFQN----FISNVGVKCLQNKPQMQKKSPKPVCGNGRLE 400

  Fly   685 SGEECDCGFNEEEC-KDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPT 748
            ..|.|||| .|.:| ...||              ..:.|..:...:|  .:|.||  ..|..:.:
Human   401 GNEICDCG-TEAQCGPASCC--------------DFRTCVLKDGAKC--YKGLCC--KDCQILQS 446

  Fly   749 SYHQKCKEETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECSGSPCLLWNMTKCFLT 813
            ....:.|...||..:..||||:.||.......:...|.|...:|..|:|..
Human   447 GVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDCHD-------------- 497

  Fly   814 STTLPHVSKRKLCDLACQD--GNDTSTCRSTSEFADKYNIQKGGISLQPGSPCDNFQGYC----- 871
                        .|..|:.  |..:    ..:.||....||         |..|.| |.|
Human   498 ------------LDARCESVFGKGS----RNAPFACYEEIQ---------SQSDRF-GNCGRDRN 536

  Fly   872 DVFLKCRAVDADGPLLRLKNLLLNRK--TLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIK---CC 931
            :.::.|          ..:||:..|.  |..|...:..:|..::.           :|::   |.
Human   537 NKYVFC----------GWRNLICGRLVCTYPTRKPFHQENGDVIY-----------AFVRDSVCI 580

  Fly   932 AVHTPSSNPKKRRARRISETLRAPMNTLRRMQRH-----PNQRGAGPRSIPPPAHEAQHYSRGGD 991
            .|.           .::..|:..|:......|..     .|:.....|.|...||.......|
Human   581 TVD-----------YKLPRTVPDPLAVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSG-- 632

  Fly   992 GRGGGGGGGGRHGGSRSHHQQH------PHDWDRHQGGHSIVPLPTGGSHSSRNSAANQARRSDG 1050
                       ||...|.::.|      |.:......|.||.|....||...|
Human   633 -----------HGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMER------------ 674

  Fly  1051 RGPRSTSSGRPQAIASGSGAASGAARSHGGYGAEQAIPGSIGGGVQAAISSGGVVARAQLPLPLP 1115
                                |||...:....|...|:|..|   |..||    |:||.||
Human   675 --------------------ASGKTENTWLLGFLIALPILI---VTTAI----VLARKQL----- 707

  Fly  1116 PPNGQQQMQQQQQLQLQQPAISPQQQPQQAFYTPKELPPRNKSRSSRTNNTSNTTTTTNSSTAAA 1180
                                        :.::..:|..|.::|:|..:..|..:.:::..||...
Human   708 ----------------------------KKWFAKEEEFPSSESKSEGSTQTYASQSSSEGSTQTY 744

  Fly  1181 GSGSVSGPGSGAGSSSKSKSGKSAKAKDSKSQKSQQANNSRSSS 1224
            .|.:.|...|.| .:|||||..||:|..|:| |||.:..::|||
Human   745 ASQTRSESSSQA-DTSKSKSEDSAEAYTSRS-KSQDSTQTQSSS 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	30/186 (16%)
		Reprolysin_2	450..659	CDD:290307	26/161 (16%)
		Disintegrin	684..776	CDD:278623	25/92 (27%)
ADAM32	NP_659441.4	Pep_M12B_propep	27..144	CDD:307618
		Reprolysin	187..383	CDD:307535	28/176 (16%)
		Disintegrin	400..474	CDD:306668	25/92 (27%)
		ADAM_CR	479..593	CDD:312126	28/185 (15%)
		SEEEED	<714..>786	CDD:317234	25/73 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	715..787		27/74 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146051
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850