Protein Alignment kuz and Adam6

DIOPT Version :9

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_620261.1
• Gene: Adam6 / 192271
• RGDID: 621472
• Length: 751
• Species: Rattus norvegicus
• Alignment Length: 823
• Identity: 147/823 - (17%)
• Similarity: 232/823 - (28%)
• Gaps: 356/823 - (43%)

  Fly   321 PQQQQQPHPPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVR 385
            |.:..:.||..:|||  .:...|.    ||...::|.    .|..||..|........::|  :|
  Rat    33 PVRCSEGHPTWRYIS--SEVVIPR----KEIYHSKGI----QTQGRLSYSLRFRGQRHIIH--LR 85

  Fly   386 RATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIW-RHIREGIADHDRGRK------YEVDE 443
            |.|                                ||| ||:.....| |:|..      :.||.
  Rat    86 RKT--------------------------------LIWPRHLLLTTQD-DQGALQMDYPFFPVDC 117

  Fly   444 KTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEH 508
            .....:..:....||.      ||.:.|          ::.|.:.||.|
  Rat   118 YYFGYLEGIPQSMVTV------NTCYGG----------LEGIMMLDDLA---------------- 150

  Fly   509 MDVSNFLNLHSLEDHSDF--CLAYVFTYRDFTGGT---------LG--LAWVASASGASGGICEK 560
                  ..:..|.|...|  .::.:.:..|.||.|         .|  |:....|:|......:.
  Rat   151 ------YEIKPLNDSQGFEHIVSQIVSEPDVTGPTNTWKRLNLNTGPPLSRTEYANGTPRMSSKN 209

  Fly   561 YKTYTETVGGQYQST----KRSLN----------------TGIITF------------------- 586
            |.::...:.||:|:|    |.|.|                :.:||.
  Rat   210 YASHPAAIKGQFQATNSIYKESNNIDTAARYLFELLSITDSFLITIHMRYYAILLTVFTESDPFA 274

  Fly   587 ---------------VNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQE-CRPGGLN--------- 626
                           .|:.:|:.|..|  |:.::.|.:....|...|. |.|.||.
  Rat   275 LEYTVPGGSIYNYYVSNFFNRLRPDAS--TVLNKDGPSDNDFHPVEQSLCTPAGLTIVGQHRRSF 337

  Fly   627 -------GNYIMFASATSGD-----------------RPN-NSKFSPCSIRNISNVLDV------ 660
                   .|.|..:.....|                 .|. ...||.||:..|:.:|:.
  Rat   338 LALSVMITNRIAMSLGIKADDETYCICHRRTTCIMYKNPEITDAFSNCSLVQINQILNTPGTMSC 402

  Fly   661 ---------LVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLN 716
                     .:..|.|         ||||..::.||:||||.::....|.||
  Rat   403 LFYDHHVYHNITKTYR---------FCGNFKIDIGEQCDCGSHKACYADPCC------------- 445

  Fly   717 SSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKE-ETECSWSSTCNGTTAECPEPRHRD 780
              ...|...|.:.|....  ||.  :||:.|:.  ..|:. :..|.....|:|....||...:..
  Rat   446 --GSNCKLTAGSICDKEL--CCA--NCTYSPSG--TLCRPIQNICDLPEYCSGNNIFCPADTYLQ 502

  Fly   781 DKTMCNNGTALCIRGECS--GSPCL-LWNMT------KCFLTSTTLPHVSKR------------- 823
            |.|.|:. ...|.:|.|:  ...|. ::.|.      ||:       .::|:
  Rat   503 DGTPCSE-EGYCYKGNCTDRSVQCKEIFGMNAKGANIKCY-------DINKQRFRFGHCTRAQES 559

  Fly   824 ----------KLCD-LACQDGNDTS------------------TCRSTSEFADKYNIQKGGISLQ 859
                      |||. |.|.  |.|:                  ||....|.........|  .::
  Rat   560 LMFNACSDHDKLCGRLQCT--NVTNLPFLQEHVSFHQSVISGFTCFGLDEHRGTETTDAG--LVK 620

  Fly   860 PGSPCD--------------------------NFQGYCDVFLKCR-----------------AVD 881
            .|:||.                          ||:|.|:....|.                 :.|
  Rat   621 HGTPCSQTNFCDRGACNGSLSRLDYDCTPEKCNFRGVCNNHRHCHCHLGWKPPLCREEGPSGSTD 685

  Fly   882 ADGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVM 924
            :..|....:.:..:|:.|          .||.:|.|..::.::
  Rat   686 SGSPPKERRTIKQSREPL----------LYLRMLFGRLYLFIV 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	64/390 (16%)
		Reprolysin_2	450..659	CDD:290307	51/310 (16%)
		Disintegrin	684..776	CDD:278623	23/92 (25%)
Adam6	NP_620261.1	Pep_M12B_propep	64..166	CDD:279848	30/174 (17%)
		ZnMc_adamalysin_II_like	217..405	CDD:239797	31/189 (16%)
		Disintegrin	428..499	CDD:278623	23/91 (25%)
		ACR	502..637	CDD:214743	25/146 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339789
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940