DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and adm-2

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_510291.1	Gene:	adm-2 / 181489	WormBaseID:	WBGene00000074	Length:	952	Species:	Caenorhabditis elegans

Alignment Length:	1035	Identity:	221/1035 - (21%)
Similarity:	334/1035 - (32%)	Gaps:	336/1035 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 PHPPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPST---------------GRRLGSSANVADW 376
            |:....||...||.|.    :|  ||.|:    ||||               ||...|..:..:.
Worm    53 PNGQNVYIPFTEDRKL----FT--ANIAD----DPSTSSLISHCHFEGVTEDGRHALSLCDPGEI 107

  Fly   377 HQLVHERVRR----ATDNGA----------GDRGS--SGGSGRGREDNK-NTCSLYIQTDPLIWR 424
            ..|:..:..|    .::||:          .|.||  ...|.:.|:..| ||   .|..:|...|
Worm   108 TGLLMTQTNRFGLSTSNNGSFVLIPYVENNCDLGSLVHSSSRKKRQIGKQNT---VIDRNPSYIR 169

  Fly   425 HIREG---------IADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRF 480
            ...:|         :||:....||:.|||   ::...:...:..:|.:|..........|..|..
Worm   170 EHLDGRKRFVELALVADYSVYTKYDSDEK---KVNDYMQQTMNILNSLYFPLNIRITLVHSEIWK 231

  Fly   481 EVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLA 545
            :..:|.:..||          ....|..|:....:    |:||. |...|:.|...|..|.:|.|
Worm   232 KGDQISVIPDS----------KETLNNFMEYKKIM----LKDHF-FDTGYLMTTLKFDEGVVGKA 281

  Fly   546 WVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNF 610
            :       .|.:|    :| :..||.|              |::|:.....|:  |.|||:||.|
Worm   282 Y-------KGTMC----SY-DYSGGIY--------------VDHNNDTVETVA--TFAHELGHTF 318

  Fly   611 GSPHDYPQECRPGGLNGNYIMFASATSGDRPNNSK-FSPCSIRNISN----VLDVLVGNTKRDCF 670
            |..||      |...:..|..........:..:.: :|.||::|:::    .:|:.:.|   :..
Worm   319 GMDHD------PNDKDVCYCPMPRCIMNPQSGHMEVWSECSVKNLASGFNRGIDLCLFN---EPG 374

  Fly   671 KASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQG 735
            |....|.|||.|||.|||||||  ..:|.:.||            |.|.  |....:.:|  :.|
Worm   375 KKPSDAKCGNGIVEPGEECDCG--PLKCDNHCC------------NGST--CKLIGEAEC--ASG 421

  Fly   736 PCCLSNSCTFVPTSYHQKCKEETE-CSWSSTCNGTTAECPEPRHRDDKTMC-NNGTALCIRGECS 798
            .||...:|.  |......|:.... |.....|||.|.:||......:..:| ......|..|.|.
Worm   422 DCCDLKTCK--PKPRATVCRAAIGICDLDEYCNGETNDCPADFFVQNAALCPGKENEFCYEGGCG 484

  Fly   799 --GSPCL-LWNMT------KCFLTST---------TLPHVSKRKLCD--------LACQ------ 831
              ...|. ||..|      .|:..:|         |..|..:.|.|:        |.|:
Worm   485 SRNDQCAKLWGPTGKNGDENCYRKNTEGTFHGNCGTNAHTKEIKKCETENAKCGLLQCETQAERP 549

  Fly   832 ----DGNDT---STCRSTSEFADK-----YNIQKGGIS-----LQP------------GSPCD-- 865
                .|:.|   ||..|:.:..||     :....||::     |.|            |..|.
Worm   550 VFGDPGSVTFSHSTVYSSLKRDDKKFCYVFKSAYGGLNAPDPGLVPDGAICGEEQMCIGQKCHKK 614

  Fly   866 --------------NFQGYCDVFLKCRAVDADGPL----------------LRLKNLLLNRKTLQ 900
                          ||:|.|:....|......|.:                .|.:.:.|:
Worm   615 EKISKVTAQCLDNCNFRGVCNNVGNCHCERGFGGIACEIPGYGGSVNSNEAYRFRGITLS----- 674

  Fly   901 TVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAVHTPSSNPKKRRARRISETLRAPMNTLRRMQRH 965
                    :.:||      |..:.|.||....|:    ...||:...:||....   ..::...|
Worm   675 --------STFLV------FFCLFGIFIGGLCVY----YRVKRKRNLVSEWWSV---VKKKFDLH 718

  Fly   966 PNQRGAGPRSIPPPAHEAQHYSRGGDGRGGGGGGGGRHGGSRSH----HQQHPHD---------- 1016
            .:.  ...|..|||.: ||...:...         ...|...||    ...||.:
Worm   719 GDL--VPVRKAPPPPY-AQRIRQSFT---------AMWGEDHSHVAVAQPAHPRNCYNSCCRQPP 771

  Fly  1017 -WDRHQGGHSIVPLPT--GGSHSSRNSAANQARRSDGRGPRSTSSG---RPQAIASGS-GAASGA 1074
             :|...     :|:.|  ..:.:|.....|.|.:.:....|:|...   .|.|.:..| .|||..
Worm   772 RFDPPS-----IPMVTLKNPNLASPTPLLNPAEKEEQNQERATHQHVELYPVAESFRSDSAASFN 831

  Fly  1075 ARSHGGYGAEQAIPGSIGGGVQ------------------AAISSGGVVARAQLPLPLPPPNGQQ 1121
            .|:           ||....||                  .|........|....||||||..::
Worm   832 TRT-----------GSFRPNVQPPPVPRPSDDVLSKLNEDLAKEKNAKFDRLNKTLPLPPPLPKE 885

  Fly  1122 QMQQQQQLQLQQ-PAISPQQQPQQAFYTPKELPPRNKSRSSRTNNTSNTTTTTNSSTAAA 1180
            :.:......|:: .:|.|:|.|          ||...:.:..|..|.....   |..|||
Worm   886 KPKTASSTSLRRNESIRPEQAP----------PPPPPAHAKPTLPTKQPKV---SEDAAA 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	60/280 (21%)
		Reprolysin_2	450..659	CDD:290307	44/213 (21%)
		Disintegrin	684..776	CDD:278623	28/92 (30%)
adm-2	NP_510291.1	Reprolysin	177..373	CDD:279729	53/250 (21%)
		ZnMc_adamalysin_II_like	177..371	CDD:239797	52/245 (21%)
		DISIN	388..463	CDD:214490	28/94 (30%)
		ACR	465..614	CDD:214743	29/148 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920