Protein Alignment kuz and adm-4

DIOPT Version :9

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_509318.1
• Gene: adm-4 / 181041
• WormBaseID: WBGene00000075
• Length: 686
• Species: Caenorhabditis elegans
• Alignment Length: 573
• Identity: 163/573 - (28%)
• Similarity: 234/573 - (40%)
• Gaps: 141/573 - (24%)

  Fly   405 RED----NKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEI-TSLIAHHVTAVNYIY 464
            |:|    .:|.|:|.:             :||:.   .|.:..|....| |..:.:.:..||.||
 Worm   178 RKDVLNVKRNRCTLKL-------------VADYS---FYSIFGKNNTGIVTKFLVNMIARVNEIY 226

  Fly   465 RNTKFD--------GRTEHRNIRFEVQRIKI-DDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSL 520
            ....:|        ||...:|:.|.::.||: |..:|..:.||.....:     :|...|...:.
 Worm   227 TPINWDVGKEDDISGRGRFQNMGFSIKEIKVLDRPNASDSHYNSYSRIW-----EVERLLREFAF 286

  Fly   521 -EDHSDFCLAYVFTYRDFTG-GTLGLAWVA--SASGASGGICEKYKTYTETVGGQYQSTKRSLNT 581
             |...||||.::.|.|.|.. .|||||:|:  .....:||||.|    .||..|:.......|:|
 Worm   287 AEGSKDFCLVHLVTARTFREVATLGLAYVSYKKWDETAGGICSK----QETFNGRVAYINVLLST 347

  Fly   582 GIITFVNYNSRVPPKVSQ---LTLAHEIGHNFGSPHDYP---------QECRPGGLN-GNYIMFA 633
               :|.|......|.:::   :.::||.||.:|:.|| |         :||.|...| |.|:|..
 Worm   348 ---SFANSEQSTYPLITKEIDIVVSHEYGHAWGATHD-PTIDSDDPDVEECSPNDQNGGKYLMSQ 408

  Fly   634 SATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCFKASEGAFCGNKIVESGEECDCGF---NE 695
            .|..|...||..|||||.:.|.   |||:|..: .||:....:||||.|||.|||||.|.   ||
 Worm   409 YAQKGYDANNVLFSPCSRKLIR---DVLIGKWE-SCFQEEMTSFCGNGIVEDGEECDNGVDTDNE 469

  Fly   696 EECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEETEC 760
            ..|.||.|  ||           |.|      .:|||....|| :.:|.|..:::.....:...|
 Worm   470 FNCCDKFC--RL-----------AVG------AKCSPLNHICC-TPTCQFHNSTHVCLPGDSLLC 514

  Fly   761 SWSSTCNGTTAECPE-PRHRDDKTMCNNGTALCIRGECSGSPCLLW------NMTKCFLTSTTLP 818
            ...:.|||.:.|||. |..||.:. |..|      |||....||.:      ....|......|.
 Worm   515 KADAVCNGFSGECPSAPPVRDGQE-CLEG------GECLNGVCLPFCEKMSIGKKSCICEDLELS 572

  Fly   819 HVSKRKLCDLACQDGNDTSTCRSTSEFADKYNIQKGGISLQPGSPCDNFQGYC-DVFLKC--RAV 880
                   |.|.|:|.|  .||...          .|.:.|:.|..|.  :|.| |  .||  ..|
 Worm   573 -------CRLCCRDYN--GTCAPV----------PGHVYLRDGVRCS--KGSCRD--RKCVNEVV 614

  Fly   881 DADGPLLRLKN-LLLNRKTLQTVAEWIVDN-------WYLVVLMGVAFIVVMG 925
            |      .::| .|:..:|...|.|:|..:       ::.::.:|:..||..|
 Worm   615 D------NVRNYFLITFQTTGGVLEFIKTHIVVIAIIFFTLIFVGIYKIVKYG 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	84/293 (29%)
		Reprolysin_2	450..659	CDD:290307	70/234 (30%)
		Disintegrin	684..776	CDD:278623	31/95 (33%)
adm-4	NP_509318.1	ZnMc_TACE_like	187..448	CDD:239798	84/293 (29%)
		Disintegrin	455..528	CDD:306668	29/92 (32%)
		ADAM17_MPD	552..610	CDD:271205	17/80 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920