DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and unc-71

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_499680.1	Gene:	unc-71 / 176706	WormBaseID:	WBGene00006804	Length:	1042	Species:	Caenorhabditis elegans

Alignment Length:	804	Identity:	179/804 - (22%)
Similarity:	265/804 - (32%)	Gaps:	274/804 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   433 HDRGRKYEVDEKTREEITSLIA----------HHVTAVNYIYRNTKFDGRTEHR--NIRF----- 480
            |:..:|.:|.::|:....:|||          |.:.|::|:..:.........|  |||.
Worm   214 HEHNKKRDVSKRTKYVEVALIADYEFMKARGLHDLDAISYMLESLNIADSMLSRDLNIRLSAVYV 278

  Fly   481 ----EVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYRDFTGGT 541
                :||||.:.:|  ...:.:|           |.::.:.|......|..:.       ||.|:
Worm   279 ELWTDVQRIDLWED--IERTLSG-----------VVDYASGHIYHIQKDASIL-------FTAGS 323

  Fly   542 LGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRS--LNTGIITF-VNYNSRVPPKVSQLTLA 603
            .....|::|  |...||                |.||  :..|:..| .::|..:        ||
Worm   324 FANQEVSNA--AIRSIC----------------TARSAVIVKGVEQFATHWNGEL--------LA 362

  Fly   604 HEIGHNFGSPHDY-------PQEC----RPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNV 657
            ..|||..|..||.       ..||    :||.:.|         .|..|.:.:||.||:..:..:
Worm   363 QSIGHLLGLEHDTTACSCEPSPECVMRQQPGRVGG---------GGGSPFSWQFSKCSVARMHGI 418

  Fly   658 LDVLVGNTKRDC-----FKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNS 717
            ..  .||.:  |     |:.||...|||.:|:..|||||| :.|.|:|.||.|..
Worm   419 WQ--DGNIQ--CLLNKPFQVSELRECGNGVVDGSEECDCG-SRENCQDPCCDPLT---------- 468

  Fly   718 SAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCK-EETECSWSSTCNGTTAECPEPRHRDD 781
                ||.|...||: :...||  :.|......  ..|: .::.|..:..|:|.:.:||...|..|
Worm   469 ----CTLRPHAQCA-AHHKCC--HRCELRKAG--DTCRSSKSPCDVAEQCDGKSGDCPPDGHLID 524

  Fly   782 KTMCNNGT-ALCIRGECSGS--PC-LLWNMTK------CFLTST---TLPHVSKRKL------CD 827
            .|:|  || ..|.||.||.|  .| .||....      ||..:|   ...:..:|:.      |.
Worm   525 GTVC--GTDGQCWRGNCSDSHQQCQKLWGREARVAEPVCFEQNTKGAEYANCGQRQADGTYHPCQ 587

  Fly   828 --------LACQDGN----DTS---------------TCRSTSEFA-----DKYN---------- 850
                    |.|..|:    |:|               .|:|.:..|     |..|
Worm   588 IEDTRCGTLHCHSGSITPIDSSLKAFTFHFTENSHQIQCKSIASAAVGLTSDGTNCASGRVCVAG 652

  Fly   851 --IQKGGISLQPGSPCDNF------QGYCDVFLKC------RAVDAD---------GPL------ 886
              ::...:|.....|.:|.      .|:|....:|      ..|..|         |.:
Worm   653 SCVEMSSVSSATACPTNNLALLCSGHGHCTTTARCVCFNGWSGVACDIRSNSSTYQGSMGFGEEG 717

  Fly   887 --------LRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAV---------- 933
                    ...|.:::....:.|..|...   ...:|:|      .|.|:..|.|
Worm   718 SGGSSQKSSERKTIMIPHLNIGTTLETAT---LFAILLG------FGVFLLLCLVCLMLCYRRRS 773

  Fly   934 ----HTPSSNPKKRRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIPPPAHEAQHYS-RGGDGR 993
                ..||....:....|..:....|.....:.:|..|::..|..:....|.|....| |..|..
Worm   774 VVEIPKPSDEKDEESPDRQIKFGNMPSYREEKRKRKSNKKIYGALNRITEADERDSTSLRSRDSA 838

  Fly   994 GGGGGGGGRHGGSRSHHQQHPHDWDRHQGGHSIV---PLPTGGSHSSRNSAANQARR------SD 1049
            ||.              ||..   ||..|...:|   ..|..|.|....|::|...|      ||
Worm   839 GGS--------------QQLV---DRRNGAPVVVGGIRDPYAGEHIYAESSSNHLTRQFRGINSD 886

  Fly  1050 GRGP-RSTSSGR---PQAIASGSG 1069
            |..| ||..|.|   |.:.||.||
Worm   887 GSYPLRSFGSWRSSAPISPASSSG 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	62/283 (22%)
		Reprolysin_2	450..659	CDD:290307	52/243 (21%)
		Disintegrin	684..776	CDD:278623	26/92 (28%)
unc-71	NP_499680.1	Pep_M12B_propep	46..179	CDD:307618
		ZnMc_adamalysin_II_like	227..429	CDD:239797	55/260 (21%)
		DISIN	446..521	CDD:214490	26/94 (28%)
		ACR	524..657	CDD:214743	29/134 (22%)
		EGF_2	666..698	CDD:285248	6/31 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010