DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and sup-17

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_492377.1	Gene:	sup-17 / 172689	WormBaseID:	WBGene00006324	Length:	922	Species:	Caenorhabditis elegans

Alignment Length:	1243	Identity:	399/1243 - (32%)
Similarity:	555/1243 - (44%)	Gaps:	388/1243 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VSIIFIIIVNGYAKDISGVKRGHERLNEYISHYETLNYDHEHIRASHNRARRSVTK-----DQYV 71
            |::||.:    :.::::|       ||.:|.::|||||...|:.....|.:||:..     .:.:
Worm    13 VTLIFCL----FFENVNG-------LNNFIDNFETLNYRATHVANQVTRRKRSIDSAASHYQEPI 66

  Fly    72 HLKFASHGRDFHLRLKRDLNTFSNKLD---FYDSK------GPIDVSTDH-IYEGEVIGDRNSYV 126
            ..:|.::.|.||::|        :.:|   |::..      |..|:...| :|||.:..|.||:|
Worm    67 GFRFNAYNRTFHVQL--------HPIDDSLFHEDHMSDVDGGYADIKPSHFLYEGYLKDDPNSHV 123

  Fly   127 FGSIHNGVFEGKIIT-ERDAYYVEHAKHYFPTNRTATTTPPSTSTTSSATTATKSTQPTRPLAKS 190
            .||:.:|||||.|.| |...|.::.|..||                      .:..:||:
Worm   124 HGSVFDGVFEGHIQTGEGRRYSIDKAAKYF----------------------ERDDRPTQ----- 161

  Fly   191 NTSTTAVNSKTENFIKKIAESTTTSQQLPEYTESSSSSTTTFPPTTEYFEDEKERNAEDELDFHS 255
                                                                          :||
Worm   162 --------------------------------------------------------------YHS 164

  Fly   256 IIYKESHV--------EDAYENVREGHVAGCGITDEVSQWMENIQNSAVEELPEPMSKDYQKLHR 312
            |||::..:        .|| ||:.| .:.|||.:..|.:.|.::|||.       .|.|:
Worm   165 IIYRDDEINHRKWRVKRDA-ENLSE-QMQGCGFSSRVRREMTDVQNSG-------ESTDF----- 215

  Fly   313 KQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWH 377
                                              :|   |:.       :.|.|...:..:.|..
Worm   216 ----------------------------------FT---NYM-------TMGGRSKRANTLRDHD 236

  Fly   378 QLVHERVRRATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIR--EGIADHDRGRKYE 440
            .|...|                           |||||:|.|..::.|||  ||..|..|
Worm   237 GLYFVR---------------------------TCSLYMQADHKLYEHIRMKEGNNDPIR----- 269

  Fly   441 VDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSAC--RNSYNGPHNA 503
                |||||.||..:|:.|||.||..|.|:|   .:.:.|.:||..|....:|  ..:.....|.
Worm   270 ----TREEIVSLFYNHIKAVNEIYEGTNFNG---IKGLHFVIQRTSIYTPDSCDRGRAKTDSDNP 327

  Fly   504 FCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASAS-GASGGICEKYKTYTET 567
            ||.|::||||||||:|..:||.|||||..|:|||.|||||||||||.. ..:||||:.::.|.|
Worm   328 FCEENVDVSNFLNLNSQRNHSAFCLAYALTFRDFVGGTLGLAWVASPQFNTAGGICQVHQRYNE- 391

  Fly   568 VGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGLNGNYIMF 632
              |......|||||||:|.|||.:|||.:|||||||||||||||||||:|.||:||..:||:|||
Worm   392 --GSRGWVYRSLNTGIVTLVNYGNRVPARVSQLTLAHEIGHNFGSPHDFPAECQPGLPDGNFIMF 454

  Fly   633 ASATSGDRPNNSKFSPCSIRNISNVLDVL--------------VGNTKRDCFKASEGAFCGNKIV 683
            |||||||:|||.||||||::|||.||.|:              ||..||:||:....|||||:|.
Worm   455 ASATSGDKPNNGKFSPCSVKNISAVLAVVLKSMPVDPTRNASPVGIGKRNCFQERTSAFCGNQIY 519

  Fly   684 ESGEECDCGFNEEECK---DKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTF 745
            |.||||||||::.:|.   ||||.|     ::...|.....|.|:...|||||||.||..::|:.
Worm   520 EPGEECDCGFSQADCDQMGDKCCVP-----HEARGNGGPGPCKRKPGAQCSPSQGYCCNPDTCSL 579

  Fly   746 VPTSYHQKCKEETECSWSSTCNGTTAECP--EPRHRDDKTMCNNGTALCIRGECSGSPCLLWNMT 808
            ...:..:.|::|:|||...||:|..|:||  .|:|  |...|.:.|.:|..|:|:||.|.::.:.
Worm   580 HGKNEEKICRQESECSNLQTCDGRNAQCPVSPPKH--DGIPCQDSTKVCSSGQCNGSVCAMFGLE 642

  Fly   809 KCFLTSTTLPHVSKRKLCDLAC-QDGNDTSTCRSTSEFADKYNI------QKGGISLQPGSPCDN 866
            .||||..     ...:||.||| :||..||:.......|::.|.      .|.|:.|.|||||:|
Worm   643 DCFLTEG-----KADELCFLACIKDGKCTSSVHLPEFSANRTNFLQNMRKDKPGLILHPGSPCNN 702

  Fly   867 FQGYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCC 931
            ::||||:|.|||:|||:|||.||||||.|::|::|:.:|..|||::|.:.|:.|:|:|..|:|||
Worm   703 YKGYCDIFRKCRSVDANGPLARLKNLLFNKRTIETLTQWAQDNWWVVGVGGLVFLVIMALFVKCC 767

  Fly   932 AVHTPSSNPKKRRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIPPPAHEAQHYSRGGDGRGGG 996
            ||||||:||.|..|..|.:||..| .||.|..|..::..||  |:||
Worm   768 AVHTPSTNPNKPPALNIYQTLTRP-GTLIRQHRQRHRAAAG--SVPP------------------ 811

  Fly   997 GGGGGRHGGSRSHHQQHPHDWDRHQGGHSIVPLPTGGSHSSRNSAANQARRSDGRGPRSTSSGRP 1061
             |.|.:                           |..|:.|:.:              |:|.|.||
Worm   812 -GPGAQ---------------------------PRSGAASAPS--------------RTTPSARP 834

  Fly  1062 QAIASGSGAASGAARSHGGYGAEQAIPGSIGGGVQAAISSGGVVARAQLPLPLPPPNGQQQMQQQ 1126
            .|                        |..:...|..|:..|.|..    |:||...:........
Worm   835 SA------------------------PPLVAPQVAVAVPPGVVGP----PIPLIATHPGSSSSTP 871

  Fly  1127 QQLQLQQPAISPQQQPQQAFYTPKELPPRNKSRSSRTNNTSNTTTTTNSSTAAAGSGSVSGPGSG 1191
            ..:.|:.|.......|..|...|:....:||.:               :|:.||||       ||
Worm   872 AVIVLEPPPPYTAADPGSAMGGPRRGHRKNKRQ---------------TSSDAAGS-------SG 914

  Fly  1192 AGSSSKSK 1199
            .|...|.|
Worm   915 NGGKKKGK 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	148/285 (52%)
		Reprolysin_2	450..659	CDD:290307	121/211 (57%)
		Disintegrin	684..776	CDD:278623	39/96 (41%)
sup-17	NP_492377.1	Pep_M12B_propep	50..142	CDD:307618	30/99 (30%)
		ZnMc_TACE_like	242..513	CDD:239798	149/312 (48%)
		DISIN	520..611	CDD:214490	39/95 (41%)
		Ribosomal_L19e	<805..897	CDD:320841	29/181 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167580
Domainoid	1	1.000	238	1.000	Domainoid score	I1282
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H113979
Inparanoid	1	1.050	601	1.000	Inparanoid score	I513
Isobase	1	0.950	-	0	Normalized mean entropy	S4570
OMA	1	1.010	-	-		QHG48710
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0006327
OrthoInspector	1	1.000	-	-		oto19575
orthoMCL	1	0.900	-	-		OOG6_104685
Panther	1	1.100	-	-	LDO	PTHR45702
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3274
SonicParanoid	1	1.000	-	-		X3482
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890