DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam24

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_034216.3	Gene:	Adam24 / 13526	MGIID:	105984	Length:	761	Species:	Mus musculus

Alignment Length:	290	Identity:	82/290 - (28%)
Similarity:	113/290 - (38%)	Gaps:	76/290 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   519 SLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRS--LNT 581
            :|:....:.:|::|....|: ...|:|:|       |.:|:|      |.|....|....  |..
Mouse   286 NLDSQIPYDIAHLFVNYTFS-NYFGIAYV-------GTVCDK------TFGCGIDSIAEDDFLTI 336

  Fly   582 GIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGL---NGNYIMFASATSGDRPNN 643
            |.|                 :|||||||.|..||        |:   .|......|||   ..::
Mouse   337 GHI-----------------VAHEIGHNLGMSHD--------GILCTCGEESCLMSAT---MDSS 373

  Fly   644 SKFSPCSIR----NISNVLDVLVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCY 704
            .|.|.||..    ::.|...:.......|.|:..   .|||.|||.||:||||.:|...:::||.
Mouse   374 QKLSNCSYEVLWAHMINKSCIHREPRPSDIFQLK---VCGNGIVEEGEQCDCGSSENCRRNRCCM 435

  Fly   705 PRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCK-EETECSWSSTCNG 768
            |               .||.|:|.:|  ..|.|| :..|...|:.  ..|: .|.||.....|||
Mouse   436 P---------------SCTLRSKAKC--DTGLCC-NRKCQIQPSG--TLCRARENECDLPEWCNG 480

  Fly   769 TTAECPEPRHRDDKTMCNNGTALCIRGECS 798
            |:.||||.....|.|.| .|...|....|:
Mouse   481 TSHECPEDLFVQDGTSC-PGDGYCYEKRCN 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	38/166 (23%)
		Reprolysin_2	450..659	CDD:290307	36/148 (24%)
		Disintegrin	684..776	CDD:278623	32/92 (35%)
Adam24	NP_034216.3	Pep_M12B_propep	42..160	CDD:366707
		Cysteine switch. /evidence=ECO:0000250	172..179
		ZnMc_adamalysin_II_like	209..395	CDD:239797	36/150 (24%)
		Disintegrin	415..488	CDD:365943	32/92 (35%)
		ACR	492..628	CDD:214743	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	725..761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836134
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850