DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam26a

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_034215.2	Gene:	Adam26a / 13525	MGIID:	105985	Length:	697	Species:	Mus musculus

Alignment Length:	727	Identity:	160/727 - (22%)
Similarity:	252/727 - (34%)	Gaps:	260/727 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 YISG--DEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDR 395
            |..|  |||.:.|....|...:. :|......|...:...::.:.:..||::.          |.
Mouse    98 YYHGYVDEDLESPVIVNTCFGSL-QGTLEINGTSYEIMPKSSTSTFEHLVYKM----------DS 151

  Fly   396 GSSGGS----GRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEV--DEKTREEITSLIA 454
            |.|..|    |...|:......|.....|.:.:...|....|.|..:|.|  |.|
Mouse   152 GDSESSPMRCGLSEEETAQQTKLQESNAPTLLQIPYENWWTHHRFIEYFVVLDHK---------- 206

  Fly   455 HHVTAVNYIYRNTKFDGRTEHRNIRFEVQ-RIKIDDDSACRNSYNGPHNAFCNEHMDV------- 511
                  .|::||         .||...:| .::|         .||.:..:.....||
Mouse   207 ------QYVHRN---------NNITTCIQDMLQI---------VNGVNGYYLQIDTDVVLTTLEV 247

  Fly   512 ---SNFLN--LHSLEDHSDFC--------------LAYVFTYRDFTGGTLGLAWVASASGASGGI 557
               .|::|  |...:...|||              :.::...:.: |..||||::|.       :
Mouse   248 WNEKNYINVELSIFKVLGDFCTWKQNMFGNRIRHDIIHLLVRQGY-GLYLGLAYLAD-------V 304

  Fly   558 CEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRP 622
            |..|                  |.|:.:.:   |.|...::.: :|||:|||||..||
Mouse   305 CTPY------------------NCGVSSVL---SDVMSDMAHI-VAHEMGHNFGMKHD------- 340

  Fly   623 GGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCFKASEGAF------CGNK 681
             |:.....:.....:..:.|:.|||.||...:.:|:      |||.|......|.      ||||
Mouse   341 -GIGCTCGLKDCLMAPYKTNSPKFSNCSYEEMYSVV------TKRSCLYDIPEALVTNLTVCGNK 398

  Fly   682 IVESGEECDCGFNEEEC-KDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTF 745
            :||.||:|||| |.|.| :|.||               :..|..:...||  :.|.||  .:|.|
Mouse   399 VVEEGEQCDCG-NSESCLQDPCC---------------SSDCVLKPGAQC--AFGLCC--KNCQF 443

  Fly   746 VPTSYHQKC-KEETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGEC--SGSPC--LLW 805
            :...  ..| ||:.||.....||||:||||...::.|...| :|...|.:.||  ....|  :..
Mouse   444 LKAG--TVCRKEKNECDLPEWCNGTSAECPGDVYKADGIPC-SGEGYCYKMECHQRDEQCRKIFG 505

  Fly   806 NMTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTCRSTSEFADKY--------------------- 849
            |.::   ::..:.::...:..|.....|||:||.| |.:.||..
Mouse   506 NGSR---SADEICYMEMNRQGDRFGNCGNDSSTYR-TCQIADVLCGQIQCENVIQLPQRRNHETV 566

  Fly   850 ------NIQ------------------KGGISLQPG------------------SP--------C 864
                  ||.                  ..|.:..|.                  ||        |
Mouse   567 HYTHFSNITCWTMDYHFGITIDDIGAVSDGTAYAPDHICVDRKCVSKSVLVSNCSPQLYHMQGIC 631

  Fly   865 DNFQG-YCDVFLK---CR------AVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVA 919
            :|.|. :|.|..|   |:      ::|:..|.|.|.:           ::|||   |:::::.|.
Mouse   632 NNKQHCHCGVTWKPPDCQKRGHGGSIDSGPPPLPLSH-----------SKWIV---YILIVLDVC 682

  Fly   920 FIVV--MGSFIK 929
            .:::  :.||.|
Mouse   683 IVIIIYLFSFYK 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	60/295 (20%)
		Reprolysin_2	450..659	CDD:290307	47/235 (20%)
		Disintegrin	684..776	CDD:278623	34/93 (37%)
Adam26a	NP_034215.2	Pep_M12B_propep	39..146	CDD:279848	9/48 (19%)
		Cysteine switch. /evidence=ECO:0000250	159..166		1/6 (17%)
		Reprolysin	195..385	CDD:279729	56/267 (21%)
		ZnMc_adamalysin_II_like	195..383	CDD:239797	56/265 (21%)
		Disintegrin	401..474	CDD:278623	34/94 (36%)
		ACR	477..613	CDD:214743	22/140 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836132
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850