DRSC/TRiP Functional Genomics Resources

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Protein Alignment kuz and Adam28

DIOPT Version :9

Sequence 1:NP_477187.1 Gene:kuz / 34772 FlyBaseID:FBgn0259984 Length:1238 Species:Drosophila melanogaster
Sequence 2:NP_034212.1 Gene:Adam28 / 13522 MGIID:105988 Length:793 Species:Mus musculus


Alignment Length:892 Identity:180/892 - (20%)
Similarity:317/892 - (35%) Gaps:326/892 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   284 VSQW--------MENIQNSAVEELPEPMSKDYQKLHRKQLH--KKSAPQQQQQPHPPKKYISGDE 338
            :.||        :..:..||::|||:  :|.|:.::..:||  :|   ::.|:|.|.:.:   :.
Mouse     1 MQQWSLLVVSFLLSPVPVSAIKELPK--AKKYEVVYPIRLHPLRK---RETQEPEPKETF---ET 57

  Fly   339 DFKYPHQ-------KYTKEAN------FAEGAFYDPSTGRRLGSSANVAD--WHQ--LVHERVRR 386
            :.:|...       .|.|:.|      ::| .:|: |:|.::.:|..:.|  ::|  :|:|:|..
Mouse    58 ELRYKMTVNGKVAVLYLKKNNKLLAPDYSE-TYYN-SSGNKVTTSPQIMDSCYYQGHIVNEKVSA 120

  Fly   387 ATDNGAGDRGSSGGSGRGRE---------------------------DNKNTCSLYIQTDPLIWR 424
            |:.:..  :|..|...:|.|                           ..|:.|.:    |..:|.
Mouse   121 ASISTC--QGLRGYISQGDEKYFIEPLSSENLDEQAHALFKDDSNEDQEKSNCGV----DDALWL 179

  Fly   425 H---------------IREG-------------IADHDRGRKYEVDEKTREEITSLIAHHVTAVN 461
            .               :.:|             :.|:...:||   .|...||..::......:|
Mouse   180 QGLHQDVALPATRLIKLNDGMVQEPKKYIEYYVVLDNGEFKKY---NKNLAEIRKIVLEMANYIN 241

  Fly   462 YIYRNTKFDGRTEHRNIRF--EVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLE--- 521
            .:|  .|.|.......:..  :..:|||..|:                :..:.||......:   
Mouse   242 MLY--NKLDAHVALVGVEIWTDGDKIKITPDA----------------NTTLENFSKWRGNDLLK 288

  Fly   522 -DHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGII- 584
             .|.|  :|.:.:..||:|.|:|||:::|       :|..|.                 :.||: 
Mouse   289 RKHHD--IAQLISSTDFSGSTVGLAFMSS-------MCSPYH-----------------SVGIVQ 327

  Fly   585 TFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDY-----PQE-CRPGGLNGNYIMFASATSGDRPNN 643
            ...||:.||..     |:|||:|||.|..|||     |.| |    :....:.|...|.      
Mouse   328 DHSNYHLRVAG-----TMAHEMGHNLGMIHDYLSCKCPSEVC----VMEQSLRFHMPTD------ 377

  Fly   644 SKFSPCSIRNISNVLDVLVGNTKRDCFKAS-------EGAFCGNKIVESGEECDCGFNEEECKDK 701
              ||.||..|....|:..:.:    |...|       ....|||:::|..|:|||| ..:||.:|
Mouse   378 --FSSCSRVNYKQFLEEKLSH----CLFNSPLPSDIISTPVCGNQLLEMNEDCDCG-TPKECTNK 435

  Fly   702 CCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCK----------E 756
            ||              .|:.|..:|..||  :.|.||             :||:          .
Mouse   436 CC--------------DARTCKIKAGFQC--ALGECC-------------EKCQLKKPGVVCRAA 471

  Fly   757 ETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECS--GSPCL-LWN------MTKCFL 812
            :.||.....|:|.::.||..|.|.:.:.|.||...|::|:|.  ...|: :|.      .|.|:.
Mouse   472 KDECDLPEVCDGKSSHCPGDRFRVNGSPCQNGHGYCLKGKCPTLQQQCMDMWGPGTKVANTSCYK 536

  Fly   813 --------------TSTTLPHVSKRKLC-DLACQDGN----------DTSTCR-----STSEFAD 847
                          ..|.:|..:|..:| .|.|:.|:          ...||:     .||:..|
Mouse   537 QNEGGTKYGYCHVENGTHMPCKAKDAMCGKLFCEGGSGDLPWKGLTISFLTCKLFDPEDTSQGVD 601

  Fly   848 K------------------YNIQKGGISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLLL 894
            .                  .:::|...|....|.|.. ...||..|:|:..:...|        .
Mouse   602 MVANGTKCGTNKVCINAECVDMEKTYKSANCSSKCKG-HAVCDHELQCQCKEGWAP--------P 657

  Fly   895 NRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAVHTPSSNPKKRRARRISETLRAPMNT- 958
            :.:...||       ::..:::||.|.:.:...:....:...|:..|:||.:|:..|..|.::. 
Mouse   658 DCENSATV-------FHFSIVVGVLFPLAVIFVVVAIVIQRQSARRKQRRVQRLPSTKDAKLHNQ 715

  Fly   959 --------------LRRMQR-H----PNQRGAGPRSI-------PPP 979
                          :.:|:: |    |::....|..:       |||
Mouse   716 KCRPQKVKDVQPQEMSQMKKLHVSDLPSEEPEPPPDVLITKPNFPPP 762

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kuzNP_477187.1 ZnMc_TACE_like 410..677 CDD:239798 63/314 (20%)
Reprolysin_2 450..659 CDD:290307 50/221 (23%)
Disintegrin 684..776 CDD:278623 27/101 (27%)
Adam28NP_034212.1 Pep_M12B_propep 42..156 CDD:279848 23/123 (19%)
Cysteine switch. /evidence=ECO:0000250 169..176 2/10 (20%)
Reprolysin 206..402 CDD:279729 58/263 (22%)
ZnMc_adamalysin_II_like 206..400 CDD:239797 58/261 (22%)
Disintegrin 419..491 CDD:278623 27/101 (27%)
ACR 496..623 CDD:214743 22/126 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 699..759 9/59 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167836123
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.850

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