DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and AgaP_AGAP004201

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_313098.5	Gene:	AgaP_AGAP004201 / 1274038	VectorBaseID:	AGAP004201	Length:	1394	Species:	Anopheles gambiae

Alignment Length:	900	Identity:	177/900 - (19%)
Similarity:	264/900 - (29%)	Gaps:	371/900 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 TEYFEDEKERNAEDELD---FHSIIYKESHVEDAYENVR-------EGHVAGCGITDEVS---QW 287
            |.:|.:|..|..||..:   .....||.|.|.||..|||       :||:.    |...|   |.
Mosquito    45 THFFPNETLRKPEDHEESRWLQGCYYKGSVVGDAQSNVRVSLCEGMQGHIK----TTNASFLIQP 105

  Fly   288 MENIQNSAVEELPEPMSKDYQKLHRKQ---LHKKSAPQQQQQ----PHPPKKYISGDEDFKYPHQ 345
            .:|..||           |.:.|||.|   ..|.|:....:.    |..|.:..|...|..|
Mosquito   106 ADNASNS-----------DARILHRIQRLMTDKTSSGNDGRTLVDGPITPAQDCSEPTDNNY--- 156

  Fly   346 KYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGREDNKN 410
                   |:.                         |.|.||:.::.|              :|..
Mosquito   157 -------FSR-------------------------HSRRRRSPEHFA--------------NNDY 175

  Fly   411 TCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKT--------------REEITSLIAHHVTAVN 461
            |..:.:             :.|:...|.:|.:.||              ...|.|.:...||.::
Mosquito   176 TVEVLV-------------VVDNQMQRYHETNLKTYVLTLMSIVSSVYADASIGSSMKIAVTHIS 227

  Fly   462 YIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSL-----E 521
            ||           |.::..:....|...:..||...:      .|.|.||:..|....:     |
Mosquito   228 YI-----------HHDLDAQTTAAKKGLEDFCRFKQS------TNIHHDVALLLTREQICRNPAE 275

  Fly   522 DHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITF 586
            ::.|               |||||.:       |.||.      :|.....|....|
Mosquito   276 NNCD---------------TLGLAEL-------GTICR------DTACAIVQDNGLS-------- 304

  Fly   587 VNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQEC---RPGGLNGNYIMFASATSGDRPNNSKFSP 648
                       :..|:|||:||..|.|||....|   |......|.||  |.|.....:..::|.
Mosquito   305 -----------ASFTIAHELGHVLGMPHDDDHRCQRYRGDSSGNNRIM--SRTIDHNTHPWQWSN 356

  Fly   649 CSIRNISNVLD-----VLVGNTKRDCFKAS--EGAFCGNKIVESGEECDCGFNEEECK------D 700
            ||.:.:|...:     .::.:...|...:.  :....|.|..          |:::|:      .
Mosquito   357 CSRQILSEYFEKHPDNCMLNHPSLDLMTSGSMDSMLAGEKFT----------NDKQCELVFGNGS 411

  Fly   701 KCC-----YPRLISEYDQSLNSSAKGCTRRAKTQCSP-------SQGPCCLSNSCTFVPTSYHQ- 752
            |.|     ..||...::..::    ||    |||..|       .:|..|....|  ||.....
Mosquito   412 KICSYMPPCARLWCSWENEMS----GC----KTQHMPWADGTECQEGHWCQKGQC--VPIDRTAL 466

  Fly   753 KCKEETECSWSS------TCNG----TTAECPEPRHRDDKTMCNNGTALCIR-GECSGSPCLLWN 806
            |.:.....:|||      ||.|    .|.||..|:.::....|   |.|.|. ..|:..||..|.
Mosquito   467 KPQNGGWSAWSSFNECSRTCGGGIQARTRECDSPKPKNGGKFC---TGLRIEYRPCNTQPCPSWR 528

  Fly   807 MT-----------------------------------KCFL--------------------TSTT 816
            ..                                   :|.|                    |..|
Mosquito   529 YNFREEQCHEMDGQNFDVPSLEPNVRWTPKYGTPVADQCKLLCRVQDKSLYFMLKEKVIDGTPCT 593

  Fly   817 LPHVS---------KRKLCDL------------ACQDGNDTSTCRSTSEFADKYNIQKGGISLQP 860
            .|..|         ::..||.            .|:  .|.||||..:   .:.|:.||.:
Mosquito   594 FPEDSFDMCINGQCRKAGCDYVLNSDAKLDQCGVCR--GDNSTCRPVT---GRLNLGKGVV---- 649

  Fly   861 GSPCDNFQGYCDVFLKCRAVDADGPL-LRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVM 924
                             |.|.:|||: .|:.....:...:.|  ..:.|..||.|:.|...|...
Mosquito   650 -----------------RRVSSDGPMEFRIPEGATSINIINT--GHMKDACYLSVMSGNEIIFND 695

  Fly   925 GSFIKCCAVHTPSSNPKKRRA------------RRISETLRAPMN---TLRRMQR 964
            ...:      ||.|:..:..|            .||:.|...|:.   |:|.:|:
Mosquito   696 PKHL------TPHSSRHRLFAGVRLEYTVTSSEERITSTFGRPLKEKLTVRVVQK 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	56/295 (19%)
		Reprolysin_2	450..659	CDD:290307	48/216 (22%)
		Disintegrin	684..776	CDD:278623	27/120 (23%)
AgaP_AGAP004201	XP_313098.5	Pep_M12B_propep	5..120	CDD:279848	26/89 (29%)
		ZnMc_ADAMTS_like	175..375	CDD:239801	55/278 (20%)
		Reprolysin	177..378	CDD:279729	54/279 (19%)
		TSP1	473..525	CDD:214559	16/54 (30%)
		ADAM_spacer1	660..761	CDD:283607	19/92 (21%)
		GON	1202..1393	CDD:285848
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910