DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and AgaP_AGAP003070

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_312756.5	Gene:	AgaP_AGAP003070 / 1273746	VectorBaseID:	AGAP003070	Length:	1683	Species:	Anopheles gambiae

Alignment Length:	1420	Identity:	399/1420 - (28%)
Similarity:	583/1420 - (41%)	Gaps:	389/1420 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LNEYISHYETLNYD-------HEHIRASHNRARRSVTKD---------QYVHLKFASHGRDFHLR 85
            :|.:|.::|...:|       |:| ...|.|.|||:..:         ..|.|.|.:|.|:|.|.
Mosquito    32 INPFIRYWEPARFDRGLLDVAHQH-HEQHRRRRRSINYEHGSAAYGPANVVRLNFRAHDREFRLV 95

  Fly    86 LKRD-LNTFSNKLDFYDSKGPIDVSTDHIYEGEVIGDRNSYVFGSI-HNGVFEGKIITERDAYYV 148
            |:.| .:.||..:...:::||:|.....||.|.|..|.:|:|.|.: .:.:|:|.::|..:.||:
Mosquito    96 LREDPRSVFSRDVQIENTEGPLDYDLSRIYTGTVEDDEHSHVHGVLTSDNLFDGTVVTNLEQYYI 160

  Fly   149 EHAKHYFP---TNRTATTTPPSTSTTSSATTATKSTQPTRPLAKSNTSTTAVNSKTENFIKKIAE 210
            |.|..|.|   ......|.....|............:|.|...:....::       |.::::.|
Mosquito   161 EPAARYSPELERRHGVHTVIYKLSDVKIHQNHHGHHRPDRGAERGRNGSS-------NSVERVPE 218

  Fly   211 STTTSQQLPEYTESSSSSTTTFPPTTEYFEDE---KERNAEDELDFHSIIYKESHVEDAYENVR- 271
              ||.|:.|     .|::.........:.|:|   :.||....||.      |....:.|..||
Mosquito   219 --TTKQRRP-----GSAAPRKMRRKRRWLEEEEIQESRNPSLPLDL------EVPYNNDYTVVRS 270

  Fly   272 EGHVAGCG------------------------ITDEVSQWMENIQN----------------SAV 296
            .|..|..|                        :.:..:.::.||.|                :..
Mosquito   271 HGKTANGGGSGSTMDTGGAAVSGASGSALFPTLNNRKNHFLYNIYNPHGSGSTIITGGGIVGAGA 335

  Fly   297 EELP-----EPMSKDYQKLHRKQLHKKSAPQQQQQP---HPPKKYISGD---------EDFKYPH 344
            |:.|     .....::.|.|..::..|:...::..|   | |...::|:         .|..:.|
Mosquito   336 EQFPWTRTINATGTNHNKDHYVEIITKNGSTRKNVPVADH-PDVMVNGNINLNVRNDLHDHHHHH 399

  Fly   345 QKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGREDNK 409
            |:                         .:....|...::.:::..|...||             |
Mosquito   400 QQ-------------------------QLLQQQQQQQQKEQKSFANSLYDR-------------K 426

  Fly   410 NTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTE 474
            :||.||:|             |||...:|...||.:.|.||    .||...|.|||.|.|:|..:
Mosquito   427 STCMLYLQ-------------ADHTFFQKMGSDEASIEAIT----RHVQRANLIYRKTDFNGDGK 474

  Fly   475 HRNIRFEVQRIKIDDDSACRN-SYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYRDFT 538
            ..||.|.::|||:.:.:|.:: ||..|.|      ..|..||.|.|.||:..|||||:||||||.
Mosquito   475 PDNITFMIKRIKVHNQNALKDPSYRFPGN------YGVEKFLELFSEEDYDAFCLAYMFTYRDFE 533

  Fly   539 GGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLA 603
            .|||||||......| ||:|||        .|.|:.:.:||||||:|.:||...|||.||.:|||
Mosquito   534 MGTLGLAWTGDLKNA-GGVCEK--------NGHYRGSLKSLNTGIVTLLNYGKHVPPAVSHVTLA 589

  Fly   604 HEIGHNFGSPHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRD 668
            |||||||||||| |::|.|||.:||:||||.|||||:.||::|||||::.|..||:....:.| .
Mosquito   590 HEIGHNFGSPHD-PEQCTPGGEDGNFIMFARATSGDKRNNNRFSPCSLKAIEPVLNAKARSAK-G 652

  Fly   669 CFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLIS---EYDQSLNSSAKGCTRRAKTQC 730
            ||...:.|.|||.:||.||:||||: ||:|||.||||  :|   .:||      |.||...|.||
Mosquito   653 CFTEPQEAICGNGVVEPGEQCDCGW-EEDCKDSCCYP--MSRHPRFDQ------KPCTLTPKAQC 708

  Fly   731 SPSQGPCCLSNSCTFVPTSYHQKCKEETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRG 795
            |||||||| :..||.   ....||:::..|...:.|:|....||...::.:||:||. ..:|..|
Mosquito   709 SPSQGPCC-TLECTL---KLGDKCRDDNGCRDPAYCDGQMPVCPPSINKPNKTICNK-EYVCYMG 768

  Fly   796 ECSGSPCLLWNMTKC-FLTSTTLPHVSKRKLCDLACQDGNDTSTCRSTSEF-------ADKYNIQ 852
            ||:||.||.:.:..| .....|.|.:   |.|:|.|:...:...|.|:.::       .|.|
Mosquito   769 ECTGSICLAYGLESCQCAVGPTDPAI---KACELCCKQPGEDRPCLSSFDWNEPPFDVPDMY--- 827

  Fly   853 KGGISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMG 917
                 .:||:||:::.|||||..|||.||..|||..|:.|||:.:::.:...||:.|||.|.|:.
Mosquito   828 -----AKPGTPCNDYNGYCDVAQKCREVDPSGPLATLRKLLLSEESIASFKRWILSNWYTVALIV 887

  Fly   918 VAFIVVMGSFIKCCAVHTPSSNPKKRRARRI----SETLRAP-------MNTLRRMQRHPNQRGA 971
            .|.:|::....|.....|   |.|.:....|    :||:|.|       ::|..|.:....::..
Mosquito   888 TAVLVLLVLSAKLLGKRT---NLKLKTVTIIHSATTETVRLPEDNNGVIVHTAVRTKVPLKKKVR 949

  Fly   972 GPRSIPPPAHEAQHYSRGGDGRGGGGG-------------------GGGRHG---------GSRS 1008
            |.||.|             .|:||.||                   .||...         .|.|
Mosquito   950 GERSKP-------------SGKGGKGGPPQTKPVAASVPKQLLTTLTGGNSATTTTTTAVLPSTS 1001

  Fly  1009 HHQQHPHDWDRHQGGHSIVPLPTGGSHS---SRNSAA---NQARRSDGRGPRSTSS---GRPQAI 1064
            ...|     .|.|...:..|...|.||.   :.|.|.   .|.:|..||...:|::   ..|:.:
Mosquito  1002 KELQ-----QRQQASGTGGPTSGGTSHHTALTTNPATIVIKQVKRHVGRTTTTTTTIVGDSPKKL 1061

  Fly  1065 --------ASGSGAASGA------------------------------------------ARSHG 1079
                    ..|.|||:||                                          |.||.
Mosquito  1062 LRKKKKRGGGGGGAAAGAPSDESPVKESPTAAAIKQPKKHKKPKSKHKEVIDYSSRNASDAHSHS 1126

  Fly  1080 G-YG-AEQAIPGSIGGGVQAAISSGGVVARAQLPLPLPPPNGQQQMQQQQQLQLQQ---PAISPQ 1139
            . :| ..:.:..|......||.:.||....|..| |...||...:.|.......||   |.::|:
Mosquito  1127 NTFGKVHRWLLESPSAAAAAATAPGGSYEHAPAP-PAAVPNLLAKSQSTPDHLAQQQPVPVVAPK 1190

  Fly  1140 QQPQ---------------QAFYTPKELPPRNKSRSSRTNNTSNTTTTTNSSTAAAGSG----SV 1185
            :..:               |..|.|   |.:...:.|:|:             .|||||    .|
Mosquito  1191 KVARVKTKSVGNLNEKVRLQVVYKP---PFKFSLKLSKTD-------------PAAGSGVKTHVV 1239

  Fly  1186 SGPGS-------------GAGSSSKSKSGKSAKAKDSKSQKSQQANNSRSSSKEK 1227
            :|||.             |.|.:.:.....:|..|.|.....||   .::.::||
Mosquito  1240 AGPGGQRKTRPLADRKRVGPGGAGEEAQQHAAARKRSAILVRQQ---QQAVAEEK 1291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	125/267 (47%)
		Reprolysin_2	450..659	CDD:290307	108/209 (52%)
		Disintegrin	684..776	CDD:278623	42/94 (45%)
AgaP_AGAP003070	XP_312756.5	Pep_M12B_propep	81..179	CDD:279848	31/97 (32%)
		ZnMc_TACE_like	428..661	CDD:239798	125/266 (47%)
		Reprolysin_2	450..644	CDD:290307	110/213 (52%)
		Disintegrin	668..751	CDD:278623	42/95 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3482
TreeFam	0	0.000	Not matched by this tool.
	3	2.920