Protein Alignment kuz and AgaP_AGAP000974

DIOPT Version :9

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: XP_309168.4
• Gene: AgaP_AGAP000974 / 1270470
• VectorBaseID: AGAP000974
• Length: 1561
• Species: Anopheles gambiae
• Alignment Length: 1228
• Identity: 249/1228 - (20%)
• Similarity: 363/1228 - (29%)
• Gaps: 500/1228 - (40%)

  Fly   328 HPPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGA 392
            ||   :..||.. |:||..:.......:|.          .:|.|: :|..   ..:||.:.:.|
Mosquito   181 HP---FYGGDLS-KHPHVIFEARTKSNKGC----------ANSGNL-EWRT---RSIRRGSSHHA 227

  Fly   393 G-----DRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEITSL 452
            |     ||   .|:||.|.|.:.| :.||:|..:|           |:....:.:..||.|:..
Mosquito   228 GLVELIDR---NGAGRYRRDVRET-TKYIETALII-----------DKAMFQKRNGSTRTEVVH- 276

  Fly   453 IAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMD----VSN 513
            .|..|..:..:|..|        .|.|..|..|:         ::.|.:.|..:...|    :||
Mosquito   277 DAIQVANIADLYFRT--------LNTRVSVVYIE---------TWQGQNQAQIDGGKDISKAISN 324

  Fly   514 F-----LNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQ 573
            |     .||:.::..:    ..:.|...|.||.:|:                  :..|||
Mosquito   325 FNDYTSRNLYKIDKDT----TQLLTGETFAGGEVGM------------------SVPETV----- 362

  Fly   574 STKRSLNTGIITFVN-YNSRVPPKVSQLTLAHEIGHNFGSPH-DYPQECRPGGLNGNYIMFASAT 636
            .|.:::  ||...:| |.    |.:...|:||.||||.|..| |...||.....:| .||..|..
Mosquito   363 CTPKAV--GISVDMNPYE----PHLLAGTMAHMIGHNIGMGHDDNRDECICRDWHG-CIMSQSIV 420

  Fly   637 SGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCF--KASEGAF---CGNKIVESGEECDCGFNEE 696
            ..:.....|||.||..:..:.|.:..|.    |.  |.:|...   |||.|||..|||||| :..
Mosquito   421 GLENVQPYKFSECSRLDYIDALRIGHGL----CLLNKPNEVELRKNCGNGIVEDDEECDCG-SAL 480

  Fly   697 EC--KDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKE-ET 758
            :|  .|.||                .|.|.:.|.:...:.||||  :.|...|...  .|:: ..
Mosquito   481 DCDKTDPCC----------------DGITCKLKKESQCATGPCC--DKCILKPPGV--ICRDAHN 525

  Fly   759 ECSWSSTCNGTTAECPEPRHRDDKTMCNN-----GTALCIRGEC--SGSPC-LLW---------- 805
            ||.....|||.:.:||...|:.:...|..     .|..|..|.|  ..:.| .:|
Mosquito   526 ECDLPEYCNGESGQCPPDVHKKNGNPCGMNSTGFSTGYCFNGVCPTQAAQCERIWGYSGTGADRV 590

  Fly   806 ---------------------NMTKCFLTSTTLPHVSKRKLCDLACQDGNDTST----------- 838
                                 |..||        .....:...|.|:||:.|..
Mosquito   591 CYEQFNSKGSINGHCGKDANGNYIKC--------EPENIQCGSLQCKDGDRTPVEDCCEHLYSRA 647

  Fly   839 ----------CRSTSEFADKYNIQKGGISLQPGSPC-DNF----QGYCDVF-------------- 874
                      |:|.:..:...|....|: ::.|:|| ||.    |....:|
Mosquito   648 IISIRGTEYECKSITGASTNSNTPPYGL-VRDGTPCGDNLICVNQTCVSIFPYIDQTKCPTNHNN 711

  Fly   875 LKCRAVDAD--------------GPLLRLK------------------NLLLNRKTLQTVAEWIV 907
            |:|.. :.|              ||...::                  .:::.:||.:..
Mosquito   712 LECSG-NGDCTNNNKCFCKFGWTGPDCSIQAHITTTYPSLITSTTSESTIIMEKKTTRYA----- 770

  Fly   908 DNWY---LVVLMGVAFIVVMGSFIKCCAVHTPSSNPKKRRARRISETLRAPMNTLRRMQRHPNQR 969
             |::   .|.|:||...||.|.|| ..|:.......|..|.:.....::.||           .:
Mosquito   771 -NYHGSNTVFLVGVLMSVVGGVFI-TFALMALCYRSKTTRLKYDPPYVKKPM-----------AK 822

  Fly   970 GAGPRSIPPPAHEAQHYSRGGDGRGGGGGGGGRHGGSRSHHQQH----------PHDWDRHQGGH 1024
            ..|      .|..|.|:|:  |.....|......|...:..:.|          ..|...|.|..
Mosquito   823 YVG------GATAANHHSQ--DDVSLEGSNKMMFGNQTTQFRDHKAIRRMTGSVSEDDPTHSGEE 879

  Fly  1025 ---SIVPLP-----------------------TGGSHSSRNSAANQARRSDG----RGPRST--S 1057
               |.:.||                       .|.....:..|||...:||.    ....||  |
Mosquito   880 ETVSFIDLPPNSLLNKQMPEKGILKKHGLGLVLGDGTKDKWHAANDDAQSDNLELIAQQESTIPS 944

  Fly  1058 SGRPQAIASGS--GAASGAARSHGGYGAEQAIPGSIGGGVQAA---ISSGGV------------- 1104
            ||....:..|.  |...|.....||.|....|.|.:||||...   |.|||:
Mosquito   945 SGGQVVVGGGGGVGVGGGVGGGVGGLGGPGVIGGVLGGGVGGGGGIIGSGGLGPGVGGVLGTVSD 1009

  Fly  1105 ---------------------VARAQ---------------LPLPL------------------- 1114
                                 .|:||               |...|
Mosquito  1010 VERTMKSLNGYHEDILEALRSAAQAQRSSANTPSGSISEELLRKTLAECVTGSQISAASVHPQDR 1074

  Fly  1115 ------------------PPPN-----------------GQQQMQQQQQLQLQQ---------PA 1135
                              |.|:                 .|||.|||||.|:||         |:
Mosquito  1075 EYKRSVSSRTGSRENVCEPQPHVLSDAGQTATLLHHHRQQQQQQQQQQQHQVQQGLLGDEDDTPS 1139

  Fly  1136 ISP-------------------------------------------------------QQQPQQA 1145
            :.|                                                       .||..|.
Mosquito  1140 VGPLRIRNLEDLIRQLEHHSSRHMSPSGSEDIRMSETEADRHYRVDSSAACSESSHGSNQQLAQV 1204

  Fly  1146 FYTPKELPP-RNKSRSSRTNNTSNTTTTTNSSTAAAGSGSVSGPGSGAGSSSKSKSGK 1202
            ..|...||| .::.|..|:::....:..........|.|.|. .|:|.||.:.|.:|:
Mosquito  1205 QKTATILPPYSSRCRPPRSDDEGRFSYGGAGGPGGGGGGGVM-VGAGGGSGTVSGTGR 1261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	65/279 (23%)
		Reprolysin_2	450..659	CDD:290307	51/219 (23%)
		Disintegrin	684..776	CDD:278623	28/94 (30%)
AgaP_AGAP000974	XP_309168.4	Pep_M12B_propep	94..195	CDD:279848	7/17 (41%)
		Reprolysin	250..454	CDD:279729	62/270 (23%)
		ZnMc_adamalysin_II_like	250..452	CDD:239797	62/268 (23%)
		Disintegrin	469..544	CDD:278623	28/95 (29%)
		ACR	548..696	CDD:214743	25/156 (16%)
		EGF_2	705..737	CDD:285248	5/32 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920