DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam9

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_001257925.1	Gene:	Adam9 / 11502	MGIID:	105376	Length:	863	Species:	Mus musculus

Alignment Length:	999	Identity:	224/999 - (22%)
Similarity:	322/999 - (32%)	Gaps:	328/999 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 ERNAEDELDFHSIIY---KESHVEDAYENVREG-HVAGCGITDEVSQWMENIQNSAVEELPEPMS 304
            |||. |.|....::|   ||..:...:.||:.. |..|         ::|.:|||||     .:|
Mouse    82 ERNT-DLLPNDFVVYTYDKEGSLLSDHPNVQSHCHYRG---------YVEGVQNSAV-----AVS 131

  Fly   305 KDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGS 369
            ..:..  |..||.::|....:..|                     .::..|..|| |..|
Mouse   132 ACFGL--RGLLHLENASFGIEPLH---------------------NSSHFEHIFY-PMDG----- 167

  Fly   370 SANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHD 434
                      :|:...|.   |..:|.:.....:|.|:.          .|.:.:.:|...|...
Mouse   168 ----------IHQEPLRC---GVSNRDTEKEGTQGDEEE----------HPSVTQLLRRRRAVLP 209

  Fly   435 RGRKYEVDEKTREEITSLIAHHVTAV--------NYIYRNTKFDGRTEHRNIRFEVQRIKIDDDS 491
            :.|..|:.....:|...::..:.|||        ||:      |......|||..:..::|..|.
Mouse   210 QTRYVELFIVVDKERYDMMGRNQTAVREEMIRLANYL------DSMYIMLNIRIVLVGLEIWTDR 268

  Fly   492 ACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGAS-- 554
            ...|...|..:...|.......||......|.:...|...|      |||.|:|:|.:....|
Mouse   269 NPINIIGGAGDVLGNFVQWREKFLITRWRHDSAQLVLKKGF------GGTAGMAFVGTVCSRSHA 327

  Fly   555 GGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQE 619
            |||         .|.||            ||...:.|.|         |||:|||.|..||..:|
Mouse   328 GGI---------NVFGQ------------ITVETFASIV---------AHELGHNLGMNHDDGRE 362

  Fly   620 CRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVL-----DVLVGNTKRDCFKASEGAFCG 679
            |..|..:   .:..|..||.|    .||.||..:...:.     ..|:...|.|  :|.....||
Mouse   363 CFCGAKS---CIMNSGASGSR----NFSSCSAEDFEKLTLNKGGSCLLNIPKPD--EAYSAPSCG 418

  Fly   680 NKIVESGEECDCGFNEEECK-DKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSC 743
            ||:|:.||||||| ..:||: |.||                :|.|.:.|:....:.|.||  ..|
Mouse   419 NKLVDPGEECDCG-TAKECEVDPCC----------------EGSTCKLKSFAECAYGDCC--KDC 464

  Fly   744 TFVPTSYHQKCKEET-ECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECS--GSPCLLW 805
            .|:|..  ..|:.:| ||.....|||::..||......:...|.|..|.|..|.|.  .:.|.:.
Mouse   465 QFLPGG--SMCRGKTSECDVPEYCNGSSQFCPPDVFIQNGYPCQNSKAYCYNGMCQYYDAQCQVI 527

  Fly   806 NMTK-------CFLT---------------STTLPHVSKRKLC-DLACQDGND-----------T 836
            ..:|       ||:.               |......:...|| .|.|::..|           .
Mouse   528 FGSKAKAAPRDCFIEVNSKGDRFGNCGFSGSEYKKCATGNALCGKLQCENVQDMPVFGIVPAIIQ 592

  Fly   837 STCRST----------SEFADKYNIQKGGISLQPGSPCDNFQ-------GY-CDVFLKCR----- 878
            :..|.|          |:..|...:.: |.....|..|.|||       .| ||:..||.
Mouse   593 TPSRGTKCWGVDFQLGSDVPDPGMVNE-GTKCDAGKICRNFQCVNASVLNYDCDIQGKCHGHGVC 656

  Fly   879 ------------------------AVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVA 919
                                    :||: ||....|:..|.        :.::..::|:|.:..|
Mouse   657 NSNKNCHCEDGWAPPHCDTKGYGGSVDS-GPTYNAKSTALR--------DGLLVFFFLIVPLVAA 712

  Fly   920 FIVVMGSFIKCCAVHTPSSNPKKRRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIPPPAHEAQ 984
            .|.:   ||            |:...|:.....|:.|:..|.......|.|....|.||
Mouse   713 AIFL---FI------------KRDELRKTFRKKRSQMSDGRNQANVSRQPGDPSISRPP------ 756

  Fly   985 HYSRGGDGRGGGGGGGGRHGGSRSHHQQHPHDWDRHQGGHSIVPLPTGGSHSSRNSAANQARRSD 1049
                ||.......||.|                         |..|.||...||........|..
Mouse   757 ----GGPNVSRPPGGPG-------------------------VSRPPGGPGVSRPPGGPGVSRPP 792

  Fly  1050 GRGPRSTSSGRPQAIASGSGAASGAARSHGGYGAEQAIPGSIGGGVQAAISSGGVVARAQLPLPL 1114
            | ||                   |.:|..||.|..:..||.   |.:..:.:......||.|...
Mouse   793 G-GP-------------------GVSRPPGGPGVSRPPPGH---GNRFPVPTYAAKQPAQFPSRP 834

  Fly  1115 PPPNGQQQMQQQQQLQLQQPAISP 1138
            |||  |.::..|..|...:||.:|
Mouse   835 PPP--QPKISSQGNLIPARPAPAP 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	66/281 (23%)
		Reprolysin_2	450..659	CDD:290307	56/223 (25%)
		Disintegrin	684..776	CDD:278623	30/93 (32%)
Adam9	NP_001257925.1	Pep_M12B_propep	55..160	CDD:279848	24/115 (21%)
		Reprolysin	212..406	CDD:279729	60/242 (25%)
		ZnMc_adamalysin_II_like	212..404	CDD:239797	60/240 (25%)
		Disintegrin	423..497	CDD:278623	30/94 (32%)
		ACR	500..636	CDD:214743	26/136 (19%)
		Drf_FH1	<747..820	CDD:283903	27/130 (21%)
		Collagen	755..810	CDD:189968	22/109 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920