DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam8

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_017177421.1	Gene:	Adam8 / 11501	MGIID:	107825	Length:	876	Species:	Mus musculus

Alignment Length:	802	Identity:	169/802 - (21%)
Similarity:	250/802 - (31%)	Gaps:	322/802 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 RLGSSANVAD-----------WHQLVHERVRRAT----DNGAGDRGSSGGSGRGREDNKNTCSLY 415
            |:||:.::.:           .:|..|.:.:..|    |....|.|            .....:|
Mouse   130 RVGSTVHLIEPLDADEEGQHAMYQAKHLQQKAGTCGVKDTNLNDLG------------PRALEIY 182

  Fly   416 IQTDPLIWRHIREG-------IADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFD--- 470
             :..|..|...||.       :||....:|....|..|:.:..::.|    |:.:|:...|.
Mouse   183 -RAQPRNWLIPRETRYVELYVVADSQEFQKLGSREAVRQRVLEVVNH----VDKLYQELSFRVVL 242

  Fly   471 -GRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFL-----NLHSLEDHSDFCLA 529
             |.......:|.:.|                   :.|  :.:.|||     ||.....|.:   .
Mouse   243 VGLEIWNKDKFYISR-------------------YAN--VTLENFLSWREQNLQGQHPHDN---V 283

  Fly   530 YVFTYRDFTGGTLGLAWV-ASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRV 593
            .:.|..||.|.|:|||.| |..|..||.:.:.:             :|.|:  |:.:
Mouse   284 QLITGVDFIGSTVGLAKVSALCSRHSGAVNQDH-------------SKNSI--GVAS-------- 325

  Fly   594 PPKVSQLTLAHEIGHNFGSPHD------YPQECRPGGLNGNYIMFASATSGDRPNNSK----FSP 648
                   |:|||:|||.|..||      |..|.|.|   |..||..|.       .||    ||.
Mouse   326 -------TMAHELGHNLGMSHDEDIPGCYCPEPREG---GGCIMTESI-------GSKFPRIFSR 373

  Fly   649 CSIRN------------ISNVLDV--LVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECK 699
            ||..:            ::||.||  .||           |..|||..||.||:|||| ..::|:
Mouse   374 CSKIDLESFVTKPQTGCLTNVPDVNRFVG-----------GPVCGNLFVEHGEQCDCG-TPQDCQ 426

  Fly   700 DKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCK-EETECSWS 763
            :.||              :|..|......:|  :.|.||  :.|...|..  :.|: .:.:|...
Mouse   427 NPCC--------------NATTCQLVKGAEC--ASGTCC--HECKVKPAG--EVCRLSKDKCDLE 471

  Fly   764 STCNGTTAECPEPRHRDDKTMCNNGTALCIRGECSGSPCL------LWN------MTKCFLTSTT 816
            ..|:|....|||...:.:.|.|..|  .|..|.|   |.|      ||.      ...|:..|
Mouse   472 EFCDGRKPTCPEDAFQQNGTPCPGG--YCFDGSC---PTLAQQCRDLWGPGARVAADSCYTFS-- 529

  Fly   817 LP-------HVSKRKLCD-LACQDGN---DTSTCRSTSEFA-----------DKYNIQKGGISLQ 859
            :|       :..:...|. |.|:.|.   :.|.|..:|...           |.:.:...|...:
Mouse   530 IPPGCNGRMYSGRINRCGALYCEGGQKPLERSFCTFSSNHGVCHALGTGSNIDTFELVLQGTKCE 594

  Fly   860 PGSPC-------------------DNFQGYCDVFLKC-------------RAVD----------- 881
            .|..|                   .|..|.|:...:|             |..|
Mouse   595 EGKVCMDGSCQDLRVYRSENCSAKCNNHGVCNHKRECHCHKGWAPPNCVQRLADVSDEQAVSSFP 659

  Fly   882 ------------ADGPLLRLKNLLL---------NRKTLQTVAEWI-----VDNWYLVVLMGVAF 920
                        |.|..|.|.:.::         :...|::...|.     |....::|::..|.
Mouse   660 VVTESAAVHSTTASGNWLGLNSGIVGLGLTTTTSSNPLLESQKSWSSTSLPVSVVVVLVILVAAM 724

  Fly   921 IVVMGSFI----------------KCCAVHTP------SSNPKKRRARRISETLRAPMNTLRRMQ 963
            ::|.|..|                ....:..|      ||.|.|.|....|||:..
Mouse   725 VIVAGIVIYRKAPRQIQRRSVAPKPISGLSNPLFYTRDSSLPAKNRPPDPSETVST--------- 780

  Fly   964 RHPNQRGAGPRSI-----PPPA 980
               ||   .||.|     ||||
Mouse   781 ---NQ---PPRPIVKPKRPPPA 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	71/307 (23%)
		Reprolysin_2	450..659	CDD:290307	56/240 (23%)
		Disintegrin	684..776	CDD:278623	24/92 (26%)
Adam8	XP_017177421.1	Pep_M12B_propep	28..152	CDD:366707	3/21 (14%)
		Reprolysin	196..395	CDD:366632	60/266 (23%)
		DISIN	412..486	CDD:214490	25/94 (27%)
		ACR	488..607	CDD:214743	24/125 (19%)
		PHA03247	<638..857	CDD:223021	32/174 (18%)
		Rib_recp_KP_reg	<771..856	CDD:368286	12/41 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920