DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and Adam7

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_031428.2	Gene:	Adam7 / 11500	MGIID:	107247	Length:	789	Species:	Mus musculus

Alignment Length:	876	Identity:	174/876 - (19%)
Similarity:	287/876 - (32%)	Gaps:	286/876 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 WM----ENIQNSAV-----EELPEPMSKDYQKLHRKQL---HKKSAPQQQQQP------------ 327
            ||    .:||...:     :||..|  |....||::.|   |....|::.::.
Mouse     8 WMTVLISHIQERGIVGVEGQELVHP--KKLPLLHKRDLERIHDSDIPEEYEEELLYEIKLGKKTL 70

  Fly   328 --H--PPKKYISGDEDFKYPHQK---YTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVR 385
              |  ..::::|.:....|.:.|   :||.....:..||..|                ::||
Mouse    71 ILHLLKAREFLSSNYSETYYNVKREVFTKHPQILDHCFYQGS----------------IIHE--- 116

  Fly   386 RATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGR----KYEVDEKTR 446
              .|:.|.....:|..|..|.:::              |::.|.:...|.|.    ||.|
Mouse   117 --FDSAASISTCNGLRGFFRVNDQ--------------RYLIEPVKYSDDGEHLVYKYNV----- 160

  Fly   447 EEITSLIAHHVTAVNYIYRNTKFD-------GRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAF 504
             :......|....:|:..::...|       ...:|...:| ::...:.|:...|.: |.|.|..
Mouse   161 -KAPYATNHSCVGLNFTKKSALIDVENIEEHNAEDHHKEKF-IELFVVADEYVYRRN-NKPQNKL 222

  Fly   505 CNEHMDVSNF-------LNLH---------------SLEDHSDFCLAYVFTY--------RDFTG 539
            ......:.||       ||:|               .:..:.:..|.:..|:        :||..
Mouse   223 RKRIWGMVNFVNMIYKTLNIHVTLAGFEIWSAGDKIEIVSNLESTLLHFSTWQETVLKKRKDFDH 287

  Fly   540 GTL--GLAWVASASGAS--GGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQL 600
            ..|  |.....|..|.:  ||||:..::.             |:...::..||        :...
Mouse   288 VILLSGKWLYTSMQGIAYPGGICQILRSC-------------SVVKDLLPDVN--------IIGN 331

  Fly   601 TLAHEIGHNFGSPHD-YPQECRPGGLNGNYIMFASATSGDRPNNS-KFSPCSIRNISNVLDVLVG 663
            .:||::||:.|..|| :|..|..|          ....||....: |||.||.......|.
Mouse   332 RMAHQLGHSLGMQHDGFPCTCPLG----------KCVMGDGSIPAIKFSKCSQTQYQQFLQ---- 382

  Fly   664 NTKRDCF-------KASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKG 721
            :.|..|.       :.::..|||||.|:.||||||| ..:||.:.||              .|..
Mouse   383 DQKPACILNNPFPEEFNDYPFCGNKKVDEGEECDCG-PVQECTNPCC--------------DAHK 432

  Fly   722 CTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKE-------ETECSWSSTCNGTTAECPEPRHR 779
            |..:....|  .:|.||  .||        |..||       :.||..|..|.|.:.|||:...:
Mouse   433 CVLKPGFTC--VEGECC--ESC--------QMKKEGAVCRLAKNECDISEVCTGYSPECPKDEFQ 485

  Fly   780 DDKTMCNNGTALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTCR---S 841
            .:...|.||...|..|.|   |......::.|:......|    .||....:.||....|:   :
Mouse   486 ANGFPCRNGEGYCFMGLC---PTRNEQCSELFIGGAEESH----SLCYRMNKKGNRFGYCKNKGN 543

  Fly   842 TSEFADKYNIQKGGISLQPGSPCDNF---QGY------CDVFLKCRA------------------ 879
            |....::.:::.|.|....|.|....   :.|      .:|.:|||.
Mouse   544 TFVPCEEKDLKCGKIYCSGGRPSSRLGEDKAYNLKNVKQNVTIKCRTMFLHHNSRDMGLVNSGTK 608

  Fly   880 -----VDADGPLLRLK---NLLL------------NRKTLQTVAEWIVDNW-------------- 910
                 |.::|..:.::   |..:            |....|.....|:..|
Mouse   609 CGDGMVCSNGECIEMEKAYNSTICSSPCDENDVDDNEPECQCEEGSIITEWGEALNLTSVSIMVI 673

  Fly   911 -YLVVLMGVAFIVVMGSFIKCCAVHTPSSNPKKRRA-------RRISETLRAPMNTLRRMQRHPN 967
             .::|::||..::::..:.||..:....|:|::.|.       ....:|...|:.|    ..||.
Mouse   674 VLVMVIIGVGLVILLIRYQKCIKMKQVQSSPREIRGVENKGYFPEEHQTRSEPILT----DIHPL 734

  Fly   968 QRGAGPRSIPPPAHEAQHY----SRGGDGRG 994
            ...|......|.:..:.||    |...|.||
Mouse   735 HTTAESLERVPSSFSSPHYITLKSVSKDSRG 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	57/320 (18%)
		Reprolysin_2	450..659	CDD:290307	47/251 (19%)
		Disintegrin	684..776	CDD:278623	30/98 (31%)
Adam7	NP_031428.2	Pep_M12B_propep	63..153	CDD:279848	20/124 (16%)
		Reprolysin	199..393	CDD:279729	46/230 (20%)
		ZnMc_adamalysin_II_like	199..391	CDD:239797	46/228 (20%)
		Disintegrin	410..482	CDD:278623	30/98 (31%)
		ACR	486..623	CDD:214743	26/143 (18%)
		Rifin_STEVOR	<655..698	CDD:301311	7/42 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..789		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836116
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850