Protein Alignment kuz and Adam4

DIOPT Version :9

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_033750.1
• Gene: Adam4 / 11498
• MGIID: 104731
• Length: 763
• Species: Mus musculus
• Alignment Length: 671
• Identity: 142/671 - (21%)
• Similarity: 211/671 - (31%)
• Gaps: 221/671 - (32%)

  Fly   298 ELPEPMSKDYQKLH----------RKQLHKKSAPQQQQQPHPPKKYISGDE-----DFKY-PHQK 346
            ::|:.|.|.....|          |..:|.|.......|..|  .|.|.|:     |:.: |...
Mouse    52 KVPQRMGKSDMSGHITYSMRFRGQRHVVHMKLKKNMIPQNFP--VYTSNDQGAQQKDYPFVPRDC 114

  Fly   347 YTKEANFAEG-----AFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGRE 406
            |.  .:|.||     |..|..||                               |..|
Mouse   115 YF--YSFLEGVPGSQAILDTCTG-------------------------------GLKG------- 139

  Fly   407 DNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYE-------VDEKTREEITSLIAHHVTAVNYIY 464
                    .||.|...:.     |.......|:|       |||::||.........:.....:.
Mouse   140 --------MIQVDDFTYE-----IKPLASSSKFEHVISLLVVDERSRESKKCRNDEIMAKAGDLS 191

  Fly   465 RNTKFDGRTEHRNI---RFEVQRIKIDDDSACRNSYNGPHNAF----CNEHMDVSNFLNLHSLED 522
            ..||..|......:   |:.::.:.|        .|...|:.|    .|....|...|.::|:.|
Mouse   192 EETKLAGSPRAAPVYLWRYHLKSVGI--------HYTVTHDLFKQTGSNSSTSVELILIMNSISD 248

  Fly   523 HSDFCLAYVFTYRD--FTGGTLGL-----------AWVASASGASGGICEKYKTYTETV------ 568
             |.:.::.:..|..  :...|..|           .|...|........|.:..|..|.
Mouse   249 -SIYKISGLIVYARGVWIWNTKNLHTVPGENPHLDPWSVMAGFGVWKSKELHDLYATTAILLASR 312

  Fly   569 -----GGQYQSTKRSLNTGII-TFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYP-------QEC 620
                 .|.:|:...:.|.|:: |:|..|...   ::...|||.:||.....||.|       ..|
Mouse   313 PKNTDYGSFQNGLCNPNWGVLFTYVGKNHLF---LAGSFLAHAVGHLLDVSHDTPGCVCFRRSSC 374

  Fly   621 RPGGLNGNYIMFASATSGDRPNNSK----------FSPCSIRNISNVLDVLVGNTKRDCFKASEG 675
                     :|....|..|..:|..          :.||....:....:|.:....|
Mouse   375 ---------LMDEFPTLHDMISNCSHNELHRRIHDWDPCLSLELKTAKEVNMYEVPR-------- 422

  Fly   676 AFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLS 740
              ||||.||:.|:||||..::...||||  .:..|:.|..:.:|               |.|||
Mouse   423 --CGNKRVEASEKCDCGSVKDCTTDKCC--EVNCEFTQGSSCAA---------------GGCCL- 467

  Fly   741 NSCTFVPTSYHQKCKEETE-CSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECSGSPCLL 804
             ||.|.||.  ..|:::.. |.....|:|.:..||...:..|.|.| :..|:||.|.||..
Mouse   468 -SCKFAPTG--TICRDKNGICDLPEYCSGASEHCPGNFYIMDGTPC-SPLAVCIAGNCSDR---- 524

  Fly   805 WNMTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTC-RSTSEFADKY-----NIQKGGISLQPGSP 863
                          |:..:.|.....:||  :..| ...:...|::     .|.:||  .|| .|
Mouse   525 --------------HLQCQALFGYQVKDG--SPACYNELNVKGDRFGNCGIRIIRGG--SQP-VP 570

  Fly   864 CDNFQGYCDVFLKCRAVDADG 884
            |...    |||  |..:..||
Mouse   571 CQKE----DVF--CGMIHCDG 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	57/322 (18%)
		Reprolysin_2	450..659	CDD:290307	44/257 (17%)
		Disintegrin	684..776	CDD:278623	28/92 (30%)
Adam4	NP_033750.1	Pep_M12B_propep	60..163	CDD:279848	27/157 (17%)
		ZnMc_adamalysin_II_like	213..406	CDD:239797	40/213 (19%)
		Reprolysin	213..405	CDD:279729	39/212 (18%)
		DISIN	429..503	CDD:214490	28/94 (30%)
		ACR	505..648	CDD:214743	28/111 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836124
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940