DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and Adam22

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_006503591.1	Gene:	Adam22 / 11496	MGIID:	1340046	Length:	980	Species:	Mus musculus

Alignment Length:	1075	Identity:	213/1075 - (19%)
Similarity:	315/1075 - (29%)	Gaps:	404/1075 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 PHQKYTKEANFAEGAF-----YDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSG 402
            |...:..:|:|...||     .|......|.||..|.  .|:.|.  .:..:|..|:.....|..
Mouse    79 PQLTHVDKASFRVDAFGTSFVLDVLLNHELLSSGYVE--RQIEHG--GKVVENKGGEHCYYQGQI 139

  Fly   403 RGREDN---KNTCSLYIQTDPLIWRHIREGIADHDRGRKY----EVDEKTREEITSLIAHHVTAV 460
            ||...:   .:||            |...|:. :|....|    |.:||::|.     :|    .
Mouse   140 RGNPVSFVALSTC------------HGLHGMF-YDGNHTYLIEPEENEKSQES-----SH----C 182

  Fly   461 NYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSAC---------RNSYNGPHNAFCNEHMDVSNFLN 516
            :.:|::.:|:...:  ::..|.||:.|......         |.....|.|.     .:.:.::.
Mouse   183 HSVYKSRQFEFPLD--DLPSEFQRVNITPPQFILKPRLKRRKRQLLRFPRNV-----EEETKYIE 240

  Fly   517 LHSLEDHSDF-----CLAYVFTY------------------------------------------ 534
            |..:.||..|     .:.|..||
Mouse   241 LMIVNDHLMFKKHRLSVVYTNTYAKSVVNMADVIYKDQLKTRIVLVAMETWAADNKFAISENPLI 305

  Fly   535 ---------RDFTGGTL-------GLAWVASASGAS--GGICEKYKTYTETVGGQYQSTKRSLNT 581
                     |||.....       |..:.:|.|||:  ||||...:.     ||..:..|..|
Mouse   306 TLREFMKYRRDFIKEKADAVHLFSGSQFESSRSGAAYIGGICSLLRG-----GGVNEFGKTDL-- 363

  Fly   582 GIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQ----ECR-----PG---GLNGNYIMFAS 634
                            ..:|||..:.||.|...|..:    ||:     .|   |..|.|:
Mouse   364 ----------------MAVTLAQSLAHNVGIISDKRKLASGECKCEDTWSGCIMGDTGYYL---- 408

  Fly   635 ATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCF-----KASEGAFCGNKIVESGEECDCGFN 694
                    ..||:.|::....:.|:...|    .|.     |..:...|||..:|:||||||| .
Mouse   409 --------PKKFTQCNVEEYHDFLNSGGG----ACLFNKPSKLLDPPECGNGFIETGEECDCG-T 460

  Fly   695 EEECK---DKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKE 756
            ..||.   .:||                |.||....:||  |.|.||  ..|.|.|..  ..|:|
Mouse   461 PAECALEGAECC----------------KKCTLTQDSQC--SDGLCC--KKCKFQPLG--TVCRE 503

  Fly   757 E-TECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECS--GSPC-LLWNMT--------- 808
            . .:|.....|:|.:::|....|:.|...|:....:|..|.|.  ...| .:|...
Mouse   504 AVNDCDIREICSGNSSQCAPNVHKMDGYSCDGTQGICFGGRCKTRDRQCKYIWGQKVTASDRYCY 568

  Fly   809 -----------KCFLTSTTLPHVSKRK-LCD-LACQ-----------DGNDTST----------C 839
                       .|.....|....:||. ||. |.|.           ||..|||          |
Mouse   569 EKLNIEGTEKGNCGKDKDTWTQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNC 633

  Fly   840 RSTSEFADKYNIQKGGISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAE 904
             |.:....:.::..|.:  :.|:||                   ||.:    :.|..:.|.
Mouse   634 -SGAHVKLEEDVDLGYV--EDGTPC-------------------GPQM----MCLEHRCLP---- 668

  Fly   905 WIVDNWYLVVLMGVAFIVVMGSFIKC--------CAVHTPSSNPKKRRARRISETLRAPMNTLRR 961
                             |...:|..|        |:.:...||           .|:...|
Mouse   669 -----------------VASFNFSTCSSSKAGTVCSGNGVCSN-----------ELKCVCN---- 701

  Fly   962 MQRHPNQRGAGPRSIPPPAHEAQHYSRGGDGRGG----GGGGGGRH------------------- 1003
              ||......|           .|:....|.:.|    |.|..|.:
Mouse   702 --RHWTGADCG-----------THFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGI 753

  Fly  1004 --GGSRSHHQQH----------PHDWDRHQGGHSIVPLPTGGSHSSRNSAANQARRSDGRGPRST 1056
              .|.:::.:|.          |.|.|....     ..|.||   |.|||::..:||:|.. .|.
Mouse   754 TAWGYKNYREQRQLPQGDYVKKPGDGDSFYS-----DFPPGG---STNSASSSKKRSNGLS-HSW 809

  Fly  1057 SSGRPQAIASGSGAASGAARSHGGYGAEQAIPGSIGG------GVQAAISSGGVVARAQLPLPLP 1115
            |...|..........:|..||:       :..|::||      |.:....|.......|.|.|
Mouse   810 SERIPDTKHISDICENGRPRSN-------SWQGNMGGNKKKIRGKRFRPRSNSTEREPQAPEP-- 865

  Fly  1116 PPNGQQQMQQQQQLQLQQPAISP--QQQPQQAFYTPKELPPRNKSRSSRTNNTSNTTTTTNSSTA 1178
               |....|     .:....|||  ...||......:.|.|..|    |..|.:......|.:|.
Mouse   866 ---GHSLAQ-----TIPSQGISPGGSDSPQTGSLDHRYLNPWFK----RDYNVAKWVEDVNKNTE 918

  Fly  1179 AAGSGSVSGPGSGAGSSSKSKSGKSAKAKDSKSQK 1213
            .....|..||.....:.|.:||..|:....:.|:|
Mouse   919 GPYFSSQDGPHQQDRTLSPAKSPSSSTGSIASSRK 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	63/361 (17%)
		Reprolysin_2	450..659	CDD:290307	49/294 (17%)
		Disintegrin	684..776	CDD:278623	30/95 (32%)
Adam22	XP_006503591.1	Pep_M12B_propep	48..186	CDD:366707	28/132 (21%)
		Reprolysin	237..436	CDD:366632	42/237 (18%)
		Disintegrin	451..524	CDD:365943	30/95 (32%)
		ACR	528..669	CDD:214743	30/187 (16%)
		EGF_2	677..709	CDD:285248	8/48 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920