Protein Alignment kuz and Adam19

DIOPT Version :9

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_033746.1
• Gene: Adam19 / 11492
• MGIID: 105377
• Length: 920
• Species: Mus musculus
• Alignment Length: 1004
• Identity: 210/1004 - (20%)
• Similarity: 311/1004 - (30%)
• Gaps: 361/1004 - (35%)

  Fly   221 YTESSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYKESHVEDAYENVREGHV--AGCG---- 279
            ||.|.:..|:|.             .:||...:|..:          .:|.|..|  :.|.
Mouse    97 YTASGNPQTSTL-------------KSEDHCFYHGTV----------RDVDESSVTLSTCRGIRG 138

  Fly   280 ---ITDEVSQWMENIQNSAVEE---------LPE---------PMSKDYQKLHRKQLHKKSAPQQ 323
               :...:|..:|.:.||..:.         ||.         |.|||:......|..|:....:
Mouse   139 LIIVRSNLSYIIEPVPNSDSQHRIYRSEHLTLPPGNCGFEHSGPTSKDWALQFTHQTKKQPRRMK 203

  Fly   324 QQQPHPPK---KYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVAD-WHQLVHERV 384
            ::..|..|   .|:..|            .|.|.:......:|.|:|...||..| :::.::.|:
Mouse   204 REDLHSMKYVELYLVAD------------YAEFQKNRHDQDATKRKLMEIANYVDKFYRSLNIRI 256

  Fly   385 RRATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEI 449
            ...                |.|               :|.|          |.|.||.|.....:
Mouse   257 ALV----------------GLE---------------VWTH----------GDKCEVSENPYSTL 280

  Fly   450 TSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNF 514
            .|.::         :|. |...:..|.|
Mouse   281 WSFLS---------WRR-KLLAQKSHDN------------------------------------- 298

  Fly   515 LNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSL 579
                          |.:.|.|.|.|.|:|||.:.:       :|..|::     ||  .|...|.
Mouse   299 --------------AQLITGRSFQGTTIGLAPLMA-------MCSVYQS-----GG--VSMDHSE 335

  Fly   580 NT-GIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGLNGNYIMFASATSGDRPNN 643
            |. |:.:               |:|||||||||..||....|.....:|..|| |:||.  .|..
Mouse   336 NAIGVAS---------------TVAHEIGHNFGMSHDSAHCCSASAADGGCIM-AAATG--HPFP 382

  Fly   644 SKFSPCSIRNISNVLDVLVG---NTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYP 705
            ..||.|:.:.:...|....|   :...|......|..|||..:|.||||||| .|||||:.||
Mouse   383 KVFSWCNRKELDRYLQTGGGMCLSNMPDTRTLYGGRRCGNGYLEDGEECDCG-EEEECKNPCC-- 444

  Fly   706 RLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEET-ECSWSSTCNGT 769
                        :|..||.:...:|  :.|.||  :.|..|...  .:|:|:. :|.....|.|.
Mouse   445 ------------NASNCTLKEGAEC--AHGSCC--HQCKLVAPG--TQCREQVRQCDLPEFCTGK 491

  Fly   770 TAECPEPRHRDDKTMCNNGTALCIRGEC--SGSPC-LLWN------MTKCF----LTSTTLPHVS 821
            :..||...::.|.|.|..|.|.|..|.|  ....| .||.      :..||    ....|..:..
Mouse   492 SPHCPTNYYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPALDLCFERVNAAGDTYGNCG 556

  Fly   822 K-------------RKLCDLACQ-------DGN----DTST--------CRSTSEFADKYNIQKG 854
            |             .|...:.||       :.|    ||:.        ||.|..:......:..
Mouse   557 KGLNGQYRKCSPRDAKCGKIQCQSTQARPLESNAVSIDTTITLNGRRIHCRGTHVYRGPEEEEGE 621

  Fly   855 GISLQP-----GSPCDN----FQGYC--DVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEW--- 905
            |..|.|     |:.|.:    |:|.|  ..|.:   .:..|.......:..|.|.......|
Mouse   622 GDMLDPGLVMTGTKCGHNHICFEGQCRNTSFFE---TEGCGKKCNGHGVCNNNKNCHCFPGWSPP 683

  Fly   906 ---------IVDNWYL------VVLMGV-AFIVVMGSFIKCCAVH-------TPSSNPKKRRAR- 946
                     .||:..|      .|:.|| :.:.|:...:..|..:       .||:.|.|.|.:
Mouse   684 FCNTPGDGGSVDSGPLPPKSVGPVIAGVFSALFVLAVLVLLCHCYRQSHKLGKPSALPFKLRHQF 748

  Fly   947 ----RISET-----------LRAPM------NTLRRMQR--HPNQRGAGPRSIP-------PPAH 981
                |:|::           |:.|.      ||...:::  ||     .||..|       |||.
Mouse   749 SCPFRVSQSGGTGHANPTFKLQTPQGKRKVTNTPESLRKPSHP-----PPRPPPDYLRVESPPAP 808

  Fly   982 EAQHYSRGGDGRGGGGGGGGRHGGSRSHHQQHP----------HDWDRHQGGHSIVPL-PTGGSH 1035
            ...|.:|........|....|...:|......|          .|:.|.:.....:|. |..|..
Mouse   809 LPAHLNRAAGSSPEAGARIERKESARRPPPSRPMPPAPNCLLSQDFSRPRPPQKALPANPVPGQR 873

  Fly  1036 SSRNSAANQARRSDGRGPRSTSSGRPQAI 1064
            :...|......:....||:..   ||.|:
Mouse   874 TGPRSGGTSLLQPPTSGPQPP---RPPAV 899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	56/270 (21%)
		Reprolysin_2	450..659	CDD:290307	45/209 (22%)
		Disintegrin	684..776	CDD:278623	31/92 (34%)
Adam19	NP_033746.1	Pep_M12B_propep	55..162	CDD:279848	16/87 (18%)
		Cysteine switch. /evidence=ECO:0000250	131..138		1/6 (17%)
		Reprolysin	211..409	CDD:279729	68/343 (20%)
		ZnMc_adamalysin_II_like	211..407	CDD:239797	68/341 (20%)
		DISIN	440..500	CDD:214490	19/79 (24%)
		ACR	502..650	CDD:214743	32/147 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	755..920		30/153 (20%)
		SH3-binding. /evidence=ECO:0000255	835..846		1/10 (10%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920