DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kuz and Adam17

DIOPT Version :9

Sequence 1:NP_477187.1 Gene:kuz / 34772 FlyBaseID:FBgn0259984 Length:1238 Species:Drosophila melanogaster
Sequence 2:NP_001264195.1 Gene:Adam17 / 11491 MGIID:1096335 Length:846 Species:Mus musculus


Alignment Length:943 Identity:209/943 - (22%)
Similarity:337/943 - (35%) Gaps:310/943 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 ERLNEYISHYETLNYDHEHIRASHNRARRSVTKDQYVHLK----FASHGRDFHLRLKRDLNTFSN 95
            |:|:..:|.|:.|:..:....:...|..:|.|     ||:    |::..|.|.|.|......||.
Mouse    33 EKLDSLLSDYDILSLANIQQHSIRKRDLQSAT-----HLETLLTFSALKRHFKLYLTSSTERFSQ 92

  Fly    96 KLD--FYDSK--GPIDVSTDHIYEGEVIGDRNSYVFGSIHNGVFEGKIITERDAYYVEHAKHYFP 156
            .|.  ..|.|  ....|...:.:.|.|:|:.:|.|...|.:.....:|.|:...|.||       
Mouse    93 NLRVVVVDGKEESEYSVKWQNFFSGHVVGEPDSRVLAHIGDDDVTVRINTDGAEYNVE------- 150

  Fly   157 TNRTATTTPPSTSTTSSATTATKSTQPTRPLAKSNTSTTAVNSKTENFIKKIAESTTTSQQLPEY 221
                                                                             
Mouse   151 ----------------------------------------------------------------- 150

  Fly   222 TESSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYKESHVEDAYENVREGHVAGCGITDEVSQ 286
                        |...:..|.|::        ..::||...::| :..::...|.|         
Mouse   151 ------------PLWRFVNDTKDK--------RMLVYKSEDIKD-FSRLQSPKVCG--------- 185

  Fly   287 WMENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKEA 351
                                                          |::.|.:...|.....:| 
Mouse   186 ----------------------------------------------YLNADSEELLPKGLIDRE- 203

  Fly   352 NFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGREDNKNTCSLYI 416
                     ||              .:.|....|||..|..                ||||.|.:
Mouse   204 ---------PS--------------EEFVRRVKRRAEPNPL----------------KNTCKLLV 229

  Fly   417 QTDPLIWRHIREGIADHDRGRKY-EVDEKTREEITS-----LIAHHVTAVNYIYRNTKFDGRTEH 475
            ..|...::::..|  :......| .....||:.:|:     .:...:..|:.|||||.:| ....
Mouse   230 VADHRFYKYMGRG--EESTTTNYLGYISGTRDRVTTDCFLEFLIELIDRVDDIYRNTSWD-NAGF 291

  Fly   476 RNIRFEVQRIKI----DDDSACRNSYNGPHNAFCNEH---MDVSNFLNLHSL---EDHSDFCLAY 530
            :....::::|:|    .:.......:| ...:|.||.   .||...|...|.   |:.|..|||:
Mouse   292 KGYGVQIEQIRILKSPQEVKPGERHFN-MAKSFPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAH 355

  Fly   531 VFTYRDFTGGTLGLAWVAS-ASGASGGICEKYKTYTETVGGQYQSTKRS--LNTGIITFVNYNSR 592
            :|||:||..||||||:|.| .:.:.||:|.| ..|..||       |::  ||:|:.:..||...
Mouse   356 LFTYQDFDMGTLGLAYVGSPRANSHGGVCPK-AYYNPTV-------KKNIYLNSGLTSTKNYGKT 412

  Fly   593 VPPKVSQLTLAHEIGHNFGSPHDYPQ---ECRPG-GLNGNYIMFASATSGDRPNNSKFSPCSIRN 653
            :..|.:.|...||:|||||:.|| |.   ||.|. ...|.|:|:..|.|||..||..||.||.::
Mouse   413 ILTKEADLVTTHELGHNFGAEHD-PDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQS 476

  Fly   654 ISNVLDVLVGNTKRDCFKASEGAFCGNKIVESGEECDCG---FNEEECKDKCCYPRLISEYDQSL 715
            |...::    :..::||:......|||..|:.|||||.|   .|    .|.||            
Mouse   477 IYKTIE----SKAQECFQERSNKVCGNSRVDEGEECDPGIMYLN----NDTCC------------ 521

  Fly   716 NSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKE--ETECSWSSTCNGTTAECPEPRH 778
            ||.   ||.:...|||....|||  .:|.|  .:..:||:|  ...|...|.|.|.::|||.|..
Mouse   522 NSD---CTLKPGVQCSDRNSPCC--KNCQF--ETAQKKCQEAINATCKGVSYCTGNSSECPPPGD 579

  Fly   779 RDDKTMCNNGTALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSK-RKLCDLACQDGNDTS--TCR 840
            .:|.|:|.:      .|:|....|              :|...: ::|...||.|.:::.  .||
Mouse   580 AEDDTVCLD------LGKCKAGKC--------------IPFCKREQELESCACVDTDNSCKVCCR 624

  Fly   841 STSEFADKY-NIQKGGISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLL------LNRKT 898
            :.|.....| :.::..:.|:.|.||.  .|:||:..||..        |:::::      :::.:
Mouse   625 NLSGPCVPYVDAEQKNLFLRKGKPCT--VGFCDMNGKCEK--------RVQDVIERFWDFIDQLS 679

  Fly   899 LQTVAEWIVDNWY-LVVLMGVAFIVVMGSFIKC 930
            :.|..:::.||.. .|::..:.|.:.....:.|
Mouse   680 INTFGKFLADNIVGSVLVFSLIFWIPFSILVHC 712

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kuzNP_477187.1 ZnMc_TACE_like 410..677 CDD:239798 89/289 (31%)
Reprolysin_2 450..659 CDD:290307 78/230 (34%)
Disintegrin 684..776 CDD:278623 32/96 (33%)
Adam17NP_001264195.1 Pep_M12B_propep 49..167 CDD:366707 30/214 (14%)
ZnMc_TACE_like 223..496 CDD:239798 89/289 (31%)
DISIN 503..578 CDD:214490 32/97 (33%)
ADAM17_MPD 600..660 CDD:374734 15/61 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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