DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam15

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_001032811.2	Gene:	Adam15 / 11490	MGIID:	1333882	Length:	864	Species:	Mus musculus

Alignment Length:	610	Identity:	137/610 - (22%)
Similarity:	205/610 - (33%)	Gaps:	209/610 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   529 AYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRV 593
            |.:.|...|:|..:|:|       ....||.     .:..||.......|: .|:.:
Mouse   302 AQLVTVTSFSGPMVGMA-------IQNSICS-----PDFSGGVNMDHSTSI-LGVAS-------- 345

  Fly   594 PPKVSQLTLAHEIGHNFGSPHDYP-QECR-PGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISN 656
                   ::|||:||:.|..||.| ..|. ||.......:..::|  |......||.||.:.:..
Mouse   346 -------SIAHELGHSLGLDHDSPGHSCPCPGPAPAKSCIMEAST--DFLPGLNFSNCSRQALEK 401

  Fly   657 VLDVLVGNT--KRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSA 719
            .|...:|:.  :|....|...:.|||..|:.||:||||| .:||.|.||        |...
Mouse   402 ALLEGMGSCLFERQPSLAPMSSLCGNMFVDPGEQCDCGF-PDECTDPCC--------DHFT---- 453

  Fly   720 KGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEET-ECSWSSTCNGTTAECPEPRHRDDKT 783
              |..|...||: |.||||  .:|...|..:  .|:..| :|.....|.|.:::||......|..
Mouse   454 --CQLRPGAQCA-SDGPCC--QNCKLHPAGW--LCRPPTDDCDLPEFCPGDSSQCPSDIRLGDGE 511

  Fly   784 MCNNGTALCIRGECS--GSPC-LLWN------MTKCFLTSTT----------------LPHVSKR 823
            .|.:|.|:|:.|.|:  ...| .||.      ...|..|:.|                :|...:.
Mouse   512 PCASGEAVCMHGRCASYARQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRSPGGSYMPCAPRD 576

  Fly   824 KLC-DLACQDGNDTSTCRSTSEFADKYNIQKGGISLQ-------------------PGSPCD--- 865
            .:| .|.||.|.......|..:...:. ::..|..|.                   ||:.|.
Mouse   577 VMCGQLQCQWGRSQPLLGSVQDRLSEV-LEANGTQLNCSWVDLDLGNDVAQPLLALPGTACGPGL 640

  Fly   866 ----------------------NFQGYCDVFLKCRAVDADGP---LLRLK-------NLLLNRKT 898
                                  :..|.||....||..:...|   :.:||       .|||:...
Mouse   641 VCIGHRCQPVDLLGAQECRRKCHGHGVCDSSGHCRCEEGWAPPDCMTQLKATSSLTTGLLLSLLL 705

  Fly   899 LQTVAEWIVDNWYLVVLMGVAF----------IVVMGSFIKCCAVHTPSSNPKKR-----RARRI 948
            |           .::||:|.::          ..:.||   .|....|.|.|.:|     ||:::
Mouse   706 L-----------LVLVLLGASYWHRARLHQRLCQLKGS---SCQYRAPQSCPPERPGPPQRAQQM 756

  Fly   949 SETLRA-------------PMNTL-RRMQ--------------------RHPNQRGAGPRSIPPP 979
            :.|.:|             |.|.: :::|                    |.|  :..||...|||
Mouse   757 TGTKQASVVSFPVPPSRPLPPNPVPKKLQAALADRSNPPTRPLPADPVVRRP--KSQGPTKPPPP 819

  Fly   980 AH------EAQHYSRGGDGRGGGGG 998
            ..      :.||  ..||..|.|.|
Mouse   820 RKPLPANPQGQH--PPGDLPGPGDG 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	34/151 (23%)
		Reprolysin_2	450..659	CDD:290307	30/131 (23%)
		Disintegrin	684..776	CDD:278623	31/92 (34%)
Adam15	NP_001032811.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..45
		Pep_M12B_propep	67..155	CDD:279848
		Cysteine switch. /evidence=ECO:0000250	177..184
		Reprolysin	214..414	CDD:279729	32/141 (23%)
		ZnMc_adamalysin_II_like	214..412	CDD:239797	32/139 (23%)
		DISIN	431..504	CDD:214490	31/92 (34%)
		ACR	509..650	CDD:214743	25/141 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..864		25/111 (23%)
		SH3-binding. /evidence=ECO:0000255	816..822		3/5 (60%)
		SH3-binding. /evidence=ECO:0000255	851..857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920