DRSC/TRiP Functional Genomics Resources

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Protein Alignment kuz and Adam12

DIOPT Version :9

Sequence 1:NP_477187.1 Gene:kuz / 34772 FlyBaseID:FBgn0259984 Length:1238 Species:Drosophila melanogaster
Sequence 2:NP_031426.2 Gene:Adam12 / 11489 MGIID:105378 Length:903 Species:Mus musculus


Alignment Length:867 Identity:193/867 - (22%)
Similarity:273/867 - (31%) Gaps:332/867 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   424 RHIREG-----------IADHDRGRKYEVD-EKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHR 476
            ||.||.           :||:...::...| ||.::.:.. ||:|   |:..||..         
Mouse   202 RHKRETLKMTKYVELVIVADNREFQRQGKDLEKVKQRLIE-IANH---VDKFYRPL--------- 253

  Fly   477 NIRFEVQRIKI-DDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCL--------AYVF 532
            |||..:..::: :|...|..|.:              .|.:||...|.....|        |.:.
Mouse   254 NIRIVLVGVEVWNDIDKCSISQD--------------PFTSLHEFLDWRKIKLLPRKSHDNAQLI 304

  Fly   533 TYRDFTGGTLGLAWVASASGA--SGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPP 595
            :...|.|.|:|:|.:.|...|  |||:...:..                              .|
Mouse   305 SGVYFQGTTIGMAPIMSMCTAEQSGGVVMDHSD------------------------------SP 339

  Fly   596 KVSQLTLAHEIGHNFGSPHDYPQ---ECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNV 657
            ..:.:|||||:|||||..||..:   .||.....|..||..|.   ..|....||.||.:::...
Mouse   340 LGAAVTLAHELGHNFGMNHDTLERGCSCRMAAEKGGCIMNPST---GFPFPMVFSSCSRKDLEAS 401

  Fly   658 LDVLVGNTKRDCF-------KASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSL 715
            |:..:|.    |.       :|..|..|||..||.||||||| ..|||.::||            
Mouse   402 LEKGMGM----CLFNLPEVKQAFGGRKCGNGYVEEGEECDCG-EPEECTNRCC------------ 449

  Fly   716 NSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCK-EETECSWSSTCNGTTAECPEPRHR 779
              :|..||.:....|  :.|.||  ..|...|..  ..|: ....|.....|.||...||...:.
Mouse   450 --NATTCTLKPDAVC--AHGQCC--EDCQLKPPG--TACRGSSNSCDLPEFCTGTAPHCPANVYL 506

  Fly   780 DDKTMCNNGTALCIRGECS--GSPCL-LWNMTK------CF--LTSTTLPH----------VSKR 823
            .|...|......|..|.|.  ...|: ||....      ||  :.|...|:          .:|.
Mouse   507 HDGHPCQGVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKDSKSAFAKC 571

  Fly   824 KLCD-----LACQDGNDTSTCRSTSEFADKYNI--QKGGISLQPGSPCDNFQGYCDVFL------ 875
            :|.|     :.||.|...... .|:..:.:.||  |:||..|..|:         .|:|      
Mouse   572 ELRDAKCGKIQCQGGASRPVI-GTNAVSIETNIPQQEGGRILCRGT---------HVYLGDDMPD 626

  Fly   876 --------KCRAVDADGPLL---RLKNLLL-----------------NRKTLQTVAEWI------ 906
                    ||    |:|.:.   |.:|:.:                 |||.....|.|.      
Mouse   627 PGLVLAGTKC----AEGKICLNRRCQNISVFGVHKCAMQCHGRGVCNNRKNCHCEAHWAPPFCDK 687

  Fly   907 --------------VDNWYLVV--------LMGVAFIVVMGSFIKCCAVHTPSSNPKKRRARRIS 949
                          .||..|.|        |:...|:|    ::|           :|...|.:.
Mouse   688 FGFGGSTDSGPIRQADNQGLTVGILVSILCLLAAGFVV----YLK-----------RKTLMRLLF 737

  Fly   950 ETLRAPMNTLRRMQRHPNQRGAGPRSIPPPAHEAQHYSRGGDGRGGGGGGGGRHGGSRSHHQQHP 1014
            ...:..|..||.:  ||::..:||       |..|.:...|.|.          ..:|:.|...|
Mouse   738 THKKTTMEKLRCV--HPSRTPSGP-------HLGQAHHTPGKGL----------LMNRAPHFNTP 783

  Fly  1015 HDWDRHQGGHSIVPLPTGGSHSSRNSAANQARRSDGRGPRSTSSGRPQAIA----SGSGAASGAA 1075
            .|                 .||.:....:.:|..|.|......|  ||.:.    ....|.||.|
Mouse   784 KD-----------------RHSLKCQNMDISRPLDARAVPQLQS--PQRVLLPLHQTPRAPSGPA 829

  Fly  1076 RSHGGYGAEQAIPGSIGGGVQAAISSGGVVARAQLPLPLPPPNGQQQMQQQQQLQLQQPAISPQQ 1140
            |                                  |||..|...|.|       .:::|  ||.|
Mouse   830 R----------------------------------PLPASPAVRQAQ-------GIRKP--SPPQ 851

  Fly  1141 QPQQAFYTPKELPPRNKSRSSR 1162
            :|         ||....||:||
Mouse   852 KP---------LPADPLSRTSR 864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kuzNP_477187.1 ZnMc_TACE_like 410..677 CDD:239798 66/285 (23%)
Reprolysin_2 450..659 CDD:290307 52/222 (23%)
Disintegrin 684..776 CDD:278623 29/92 (32%)
Adam12NP_031426.2 Pep_M12B_propep 64..161 CDD:279848
Cysteine switch. /evidence=ECO:0000250 175..182
Reprolysin 212..414 CDD:279729 60/265 (23%)
ZnMc_adamalysin_II_like 212..412 CDD:239797 60/263 (23%)
DISIN 437..505 CDD:214490 24/88 (27%)
ACR 508..650 CDD:214743 33/155 (21%)
CAC1F_C <751..>848 CDD:293490 32/175 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 753..790 12/70 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 819..903 22/98 (22%)
SH3-binding, class II 824..830 3/5 (60%)
SH3-binding, class I 830..837 4/40 (10%)
SH3-binding, class II 846..852 3/7 (43%)
NSP2-B_epitope <848..>896 CDD:258894 10/26 (38%)
SH3-binding, class I 852..858 3/14 (21%)
SH3-binding, class I 881..887
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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