Protein Alignment kuz and AgaP_AGAP013468

DIOPT Version :9

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: XP_003436497.1
• Gene: AgaP_AGAP013468 / 11175547
• VectorBaseID: AGAP013468
• Length: 1082
• Species: Anopheles gambiae
• Alignment Length: 1140
• Identity: 223/1140 - (19%)
• Similarity: 345/1140 - (30%)
• Gaps: 479/1140 - (42%)

  Fly   338 EDFKYPHQK-------YTKEANFAEGAFYDPSTGRRLGSSANVA-------------------DW 376
            |::.:.||.       ...:....|...|:.:...|.||...::                   ::
Mosquito   134 EEYTFVHQSPEGQDIVERLDRQSVELCHYEGTVRERPGSRVAISTCSGSIDGVIYERNETYLIEY 198

  Fly   377 HQLVHERVRR-----ATDNGAGDRGSSGGSGRGRED-------NKNTCSLYIQTDPLIWRHIREG 429
            |...|...||     ..||...:..:.|...|..:.       .::..||:::   |:.
Mosquito   199 HNNTHLLYRRRYKRDVQDNELANEEAGGSRPRNNQQPAFSTGYREDADSLFVE---LVL------ 254

  Fly   430 IADHDRGRKYEVD-EKTREEITSLIAHHVTAVNYIYR--------------NTKFDGRTEHRNIR 479
            :.|.....|:..: ::..:...|:    |..:|.:||              ||:
Mosquito   255 VVDRTLFLKFSSNVQRVHQHCLSV----VNVLNELYRPLNIYILLVGVVLWNTR----------- 304

  Fly   480 FEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLN------LHSLEDHSDFCLAYVFTYRDFT 538
               ..|.|..||                ...:::||.      |..:.:.:    |::.|...|.
Mosquito   305 ---DNIVISTDS----------------KQTLTSFLAYRRERLLRQIPNDN----AHLLTAVRFP 346

  Fly   539 GGTLG---LAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQL 600
            .|.:|   |..:.||:| ||||.                            |..|..|.|..:
Mosquito   347 DGVIGKAELGSMCSAAG-SGGIA----------------------------VVENFVVTPLAT-- 380

  Fly   601 TLAHEIGHNFGSPHDYPQECR----PGGLNGNYIMFAS-ATSGDRPNNSKFSPCSIRNISNVLDV 660
            |:|||:||||...|| .:||.    ||  .|..||.|. :.|.|.||  ::|.||:.:....|
Mosquito   381 TVAHELGHNFNVDHD-TEECSGSRCPG--VGPCIMEAKLSDSTDIPN--RWSDCSVEDFRLSL-- 438

  Fly   661 LVGNTKRD---CFKASEG-----AFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNS 717
                 ||.   |.|....     |.|||.::|.||:|||| ..:.|.:.||
Mosquito   439 -----KRGLAACLKNKPSRLLVRAVCGNGLLEPGEQCDCG-RRDRCDNGCC-------------- 483

  Fly   718 SAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEE-TECSWSSTCNGTTAECPEPRHRDD 781
            .|:.|..||...|  :.|.||...:|.  |......|:|. .||.....|:|.:..||:.....|
Mosquito   484 DARTCQLRANATC--ATGSCCDLATCQ--PKRAGSVCREAGGECDLPEYCDGASELCPKDVFVRD 544

  Fly   782 KTMCNNGTALCIRGEC----------------SG---------------------------SPCL 803
            .:.|.:|.|.|.||||                ||                           .||.
Mosquito   545 TSPCGSGDAYCYRGECNTRDRQCRRLWGPTARSGLEVCYEANVNGTVFGNCGNDLAQGDGYEPCA 609

  Fly   804 LWNMTKCFL--------------------TSTTLPHVSKR-----KLC-----DLACQ------- 831
            :.:| .|.|                    |:|...|...|     .:|     ||..:
Mosquito   610 VHDM-HCGLLHCTHQSEKLEFGVEAYAKRTATKFQHYGPRGTVRTTICNAVIVDLGLEVVNPGLV 673

  Fly   832 -DGNDTST--------CRSTSEFADKYNIQKGGISLQPGSPCD---NFQGYCDVFLKCR------ 878
             ||.....        |.:.|...::.:|         |..|.   |.:|.|:....|.
Mosquito   674 PDGTKCGAGRMCFGQQCVAISRLQEEQDI---------GDECPADCNGRGVCNSEGHCHCEPGFA 729

  Fly   879 -----------AVDADGPLLR----LKNLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFI 928
                       ::|: ||..|    :.::||.               .||..:.|..|:::.||:
Mosquito   730 PPFCDGPGDGGSIDS-GPAGRSGNSMPDVLLK---------------VLVPTLTVGGILMIVSFV 778

  Fly   929 KCCAVHTPSSNPKKRRARRISETLRAPMNTLR-RMQRH----------------PNQRGAGPRS- 975
            ......|           .:...||..:...| |...|                |:.:.:|.|:
Mosquito   779 TLIVKRT-----------LVMAQLRVVLKRFRERKYGHIVVPPASPTAVVPPAVPSSKASGERNG 832

  Fly   976 --------IPPP-------------------------------------AH---EAQHYSRGGDG 992
                    :|||                                     ||   .|:.:.|
Mosquito   833 ANEVRRPPVPPPPPLPEPKQPQCFINVNISKDGKVTIADKLIDSPFLHNAHVVDTAEAFRR---- 893

  Fly   993 RGGGGGGGGRHGGSRSH------HQQHP-HDWDRHQGGHSIVPLPTGGSHSSRNSAANQARRSDG 1050
                     |....||:      ..:|| ...:.|:...:..|.|.....||.|:...:.:::|.
Mosquito   894 ---------RLLQERSYSVESATSSEHPLVTAETHKPTTASTPEPAHPEGSSFNTVLQELKQTDR 949

  Fly  1051 ----RGPRSTSSGRPQAIASGSGAASGAARSHGGYGAEQAIPGSIGGGVQAAISSGGVVAR---- 1107
                :..||.|..||           ..||      ....:|.      |..||....:.|
Mosquito   950 MHTFQNQRSKSDERP-----------APAR------LLPKLPR------QYTISDFDSIERLPDV 991

  Fly  1108 -AQLPLPL----PPPNGQQQMQQQQQLQLQQPAISPQQQPQQAFYT--PKELPPRNKSRSSRTNN 1165
             .:.|.|:    .||:            ..:|.:.|:..|:.|..|  |:.||       |..:.
Mosquito   992 DEEAPEPVCKAAKPPS------------TPKPIVIPRPLPRVAPATPGPRLLP-------STPSA 1037

  Fly  1166 TSNTTTTTNSSTAAAGSGSVSGPGSGAG-SSSKSK 1199
            |.|.::|......|...|...||..|:. ::.|:|
Mosquito  1038 TGNDSSTGKVKPTAGAPGPAKGPAGGSNVAALKAK 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	66/303 (22%)
		Reprolysin_2	450..659	CDD:290307	56/236 (24%)
		Disintegrin	684..776	CDD:278623	28/92 (30%)
AgaP_AGAP013468	XP_003436497.1	Pep_M12B_propep	96..197	CDD:279848	8/62 (13%)
		Reprolysin	249..450	CDD:279729	64/290 (22%)
		ZnMc_adamalysin_II_like	249..448	CDD:239797	63/288 (22%)
		Disintegrin	465..540	CDD:278623	28/93 (30%)
		ACR	543..691	CDD:214743	25/148 (17%)
		EGF_2	706..733	CDD:285248	5/26 (19%)
		PRK10905	<921..>1071	CDD:236792	39/191 (20%)
		DUF3682	1002..>1062	CDD:289231	18/78 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920