DRSC/TRiP Functional Genomics Resources

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Protein Alignment kuz and ADAM30

DIOPT Version :9

Sequence 1:NP_477187.1 Gene:kuz / 34772 FlyBaseID:FBgn0259984 Length:1238 Species:Drosophila melanogaster
Sequence 2:NP_068566.2 Gene:ADAM30 / 11085 HGNCID:208 Length:790 Species:Homo sapiens


Alignment Length:375 Identity:103/375 - (27%)
Similarity:140/375 - (37%) Gaps:128/375 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   524 SDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVN 588
            ||:  |:::..|.:..   .|||      :.|.:|.     .|..|    |....|:|.|:....
Human   290 SDW--AHLYLQRKYND---ALAW------SFGKVCS-----LEYAG----SVSTLLDTNILAPAT 334

  Fly   589 YNSRVPPKVSQLTLAHEIGHNFGSPHD--YPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSI 651
            ::            |||:||..|..||  |.| || |.||   .:..|..:|       ||.||.
Human   335 WS------------AHELGHAVGMSHDEQYCQ-CR-GRLN---CIMGSGRTG-------FSNCSY 375

  Fly   652 RNISNVLDVLVGNTKRDCFKASEG-----AFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEY 711
              ||....:..|.|   |.....|     ..|||||||..||||||..||..||:||        
Human   376 --ISFFKHISSGAT---CLNNIP
GLGYVLKRCGNKIVEDNEECDCGSTEECQKDRCC-------- 427

  Fly   712 DQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEE-TECSWSSTCNGTTAECPE 775
             ||      .|..:....|  |.|.||  :.|.|.|:.|  .|::| .||..:..|:|.::.||.
Human   428 -QS------NCKLQPGANC--SIGLCC--HDCRFRPSGY--VCRQEGNECDLAEYCDGNSSSCPN 479

  Fly   776 PRHRDDKTMCNNGTALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSKRKLCD---LACQDGNDTS 837
            ..::.|                 |:||....  :||           ||.|.   :.||......
Human   480 DVYKQD-----------------GTPCKYEG--RCF-----------RKGCRSRYMQCQSIFGPD 514

  Fly   838 TCRSTSEFADKYNIQKGGISLQPGSPCDNFQGYCDV-----FLKCRAVDA 882
            ...:.||..|..|:..           |.| |.|::     |.||.:.::
Human   515 AMEAPSECYDAVNLIG-----------DQF-GNCEITGIRNFKKCESANS 552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kuzNP_477187.1 ZnMc_TACE_like 410..677 CDD:239798 42/159 (26%)
Reprolysin_2 450..659 CDD:290307 38/136 (28%)
Disintegrin 684..776 CDD:278623 33/92 (36%)
ADAM30NP_068566.2 Pep_M12B_propep 60..159 CDD:279848
Cysteine switch. /evidence=ECO:0000250 170..177
Reprolysin 203..393 CDD:279729 41/151 (27%)
ZnMc_adamalysin_II_like 203..391 CDD:239797 41/149 (28%)
Disintegrin 408..481 CDD:278623 33/93 (35%)
ACR 484..626 CDD:214743 22/111 (20%)
cysteine-rich domain 494..679 18/82 (22%)
transmembrane domain 680..705
cytoplasmic domain 706..790
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 720..790
5 X 9 AA approximate repeats 732..776
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146049
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.850

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