DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam33

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_291093.2	Gene:	Adam33 / 110751	MGIID:	1341813	Length:	797	Species:	Mus musculus

Alignment Length:	928	Identity:	195/928 - (21%)
Similarity:	294/928 - (31%)	Gaps:	333/928 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 PLAKSNTSTTAVNSKTENFIKKIAESTTTSQQL--PEYTESSSSSTTTFPPTTEYFEDEKERNAE 248
            |:.|.::...|:.::.::.:.::.:    ..:|  |.|||      |.:.|
Mouse    60 PILKPDSVLVALEAEGQDLLLELEK----KHKLLAPGYTE------THYRP-------------- 100

  Fly   249 DELDFHSIIYKESHVEDAYENVREGHVAGCGITDEVSQWMENIQNSAVEELPEPMSKDYQKLHRK 313
               |.|.::...:|.:....:   |.|.|..     ..|:.....|.:..|....||....|
Mouse   101 ---DGHPVVLSPNHTDHCQYH---GRVRGFR-----ESWVVLSTCSGMSGLIVLSSKVSYYL--- 151

  Fly   314 QLHKKSAPQQQQQPHPPKKYISGD-EDFKYPHQKYTKEANFA-EGAFYDPSTGRRLGSSANVADW 376
                        ||..|     || :||. .|:.:..|..|. .|...|.::..:.|    :|..
Mouse   152 ------------QPRTP-----GDTKDFP-THEIFRMEQLFTWRGVQRDKNSQYKAG----MASL 194

  Fly   377 HQLVHERVRRATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEV 441
            ..:...||||          .:..|.|..|       |||..|..::....:.: :|.|.|..||
Mouse   195 PHVPQSRVRR----------EARRSPRYLE-------LYIVADHTLFLLQHQNL-NHTRQRLLEV 241

  Fly   442 DEKTREEITSLIAHHVTAVNYIYRN-------TKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNG 499
                           ...|:.|.|.       |..:..||.     ::.||..|.:.........
Mouse   242 ---------------ANCVDQILRTLDIQLVLTGLEVWTEQ-----DLSRITQDANETLWAFLQW 286

  Fly   500 PHNAFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTY 564
            ....:.....|.:..|                 |.|.|.|.|:|||.|.       |||.
Mouse   287 RRGVWARRPHDSTQLL-----------------TGRTFQGTTVGLAPVE-------GICR----- 322

  Fly   565 TETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQEC--RPGGLNG 627
            .|:.||                |:.:....|..:..|:||||||:.|..|| |:.|  :.....|
Mouse   323 AESSGG----------------VSTDHSELPIGTAATMAHEIGHSLGLHHD-PEGCCVQADAEQG 370

  Fly   628 NYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCFKASEG---------------AF 677
            ..:|  .|.:| .|....||.||.|.:            |..|:...|               :.
Mouse   371 GCVM--EAATG-HPFPRVFSACSRRQL------------RTFFRKGGGPCLSNTSAPGLLVLPSR 420

  Fly   678 CGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNS 742
            |||..:|:||||||| :.::|.|.||:              |..|:.||..||  :.|.||.  .
Mouse   421 CGNGFLEAGEECDCG-SGQKCPDPCCF--------------AHNCSLRAGAQC--AHGDCCA--R 466

  Fly   743 CTFVPTSYHQKCK-EETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECSGSPCL--- 803
            |..  .|....|: ..|:|.....|.||:..||...:..|.:.|..|...|:.|.|   |.|
Mouse   467 CLL--KSAGTPCRPAATDCDLPEFCTGTSPYCPADVYLLDGSPCAEGRGYCLDGWC---PTLEQQ 526

  Fly   804 ---LWN------MTKCFLTSTT----------------LPHVSKRKLC-DLACQDGN-------- 834
               ||.      ...||....:                ||...:..|| .|.||.|.
Mouse   527 CQQLWGPGSKPAPEPCFQQMNSMGNSQGNCGQDHKGSFLPCAQRDALCGKLLCQGGEPNPLVPHI 591

  Fly   835 ---DTS--------TCRSTSEFADKYNIQKGGISLQPGSPCD----------------------- 865
               |::        .||......|.:..|.....::||:.|.
Mouse   592 VTMDSTILLEGREVVCRGAFVLPDSHLDQLDLGLVEPGTGCGPRMVCQDRHCQNATSQELERCLT 656

  Fly   866 --NFQGYCDVFLKCR-----------------AVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWY 911
              :..|.|:....|.                 :||: ||...     .||           |.:.
Mouse   657 ACHNGGVCNSNRNCHCAAGWAPPFCDKPGLGGSVDS-GPAQS-----ANR-----------DAFP 704

  Fly   912 LVVLMGVAFIVVMGSFIKCCAVHTPSSNPKK----RRARRISETLRAPMNTLRRMQRHPNQRGA- 971
            |.:|:.....::.|:.:..|....|:...::    ||....:..:  |:.::     ||.:.|:
Mouse   705 LAMLLSFLLPLLPGAGLAWCYYQLPTFCHRRGLCCRRDPLWNRDI--PLGSV-----HPVEFGSI 762

  Fly   972 --GPRSIPPPAHEAQHYS 987
              |..|.|||....|..|
Mouse   763 ITGEPSPPPPWTSCQQRS 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	62/290 (21%)
		Reprolysin_2	450..659	CDD:290307	50/217 (23%)
		Disintegrin	684..776	CDD:278623	31/92 (34%)
Adam33	NP_291093.2	Pep_M12B_propep	57..165	CDD:279848	29/160 (18%)
		Cysteine switch. /evidence=ECO:0000250	132..139		1/6 (17%)
		Reprolysin	211..408	CDD:279729	64/285 (22%)
		ZnMc_adamalysin_II_like	211..408	CDD:239797	64/285 (22%)
		DISIN	427..501	CDD:214490	31/94 (33%)
		ACR	503..645	CDD:214743	28/144 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..797		6/15 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920