DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and ADAM28

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_055080.2	Gene:	ADAM28 / 10863	HGNCID:	206	Length:	775	Species:	Homo sapiens

Alignment Length:	891	Identity:	197/891 - (22%)
Similarity:	316/891 - (35%)	Gaps:	297/891 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 SAVEELPEPMSKDYQ-----KLHRKQLHKKSA--PQQQQQPHPPKKY---ISGDEDFKYPHQKYT 348
            ||::|||.  .|.|:     :||  .|||:.|  |:||:|.....||   |:|.....|    ..
Human    17 SAIKELPG--VKKYEVVYPIRLH--PLHKREAKEPEQQEQFETELKYKMTINGKIAVLY----LK 73

  Fly   349 KEANFAEGAF---YDPSTGRRLGSSANVAD--WHQ--LVHERVRRAT-DNGAGDRG-SSGGSGR- 403
            |..|.....:   |..|||:.:.:|..:.|  ::|  :::|:|..|: ....|.|| .|.|..|
Human    74 KNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTCRGLRGYFSQGDQRY 138

  Fly   404 -----------GRE--------DNKN---TCSLYIQTDPLIWRH-IREGIA-------------- 431
                       |:|        |.||   ||.:    |.::|.| :::.||
Human   139 FIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGM----DGVLWAHDLQQNIALPATKLVKLKDRKV 199

  Fly   432 -DHDRGRKYEV---------DEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIK 486
             :|::..:|.:         ..:.::||...:......||.:|:............|..:..:||
Human   200 QEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIK 264

  Fly   487 IDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVAS-A 550
            |.           |:.:|..|:........|...:.|.   :|.:.|..:..|.|:|||:::: .
Human   265 IT-----------PNASFTLENFSKWRGSVLSRRKRHD---IAQLITATELAGTTVGLAFMSTMC 315

  Fly   551 SGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPH- 614
            |..|.|:.:.:......|.|                              |:|||:|||||..|
Human   316 SPYSVGVVQDHSDNLLRVAG------------------------------TMAHEMGHNFGMFHD 350

  Fly   615 DYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDC-FKAS----- 673
            ||..:| |..:    .:...|.|...|.:  ||.||..:.....:..:.|    | |.|.
Human   351 DYSCKC-PSTI----CVMDKALSFYIPTD--FSSCSRLSYDKFFEDKLSN----CLFNAPLPTDI 404

  Fly   674 -EGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPC 737
             ....|||::||.||:|||| ..|||.:.||              .||.|..:|..||  :.|.|
Human   405 ISTPICGNQLVEMGEDCDCG-TSEECTNICC--------------DAKTCKIKATFQC--ALGEC 452

  Fly   738 CLSNSCTFVPTSYHQKCK-EETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECSGSP 801
            |  ..|.|....  ..|: .:.||.....|||.:..||:.|.:.:...|::|...|:.|.|   |
Human   453 C--EKCQFKKAG--MVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTC---P 510

  Fly   802 CL------LWNM------TKCF--------------LTSTTLPHVSKRKLC-DLACQDGNDT--- 836
            .|      ||..      ..|:              :..|.:|..:...:| .|.||.|:|.
Human   511 TLQEQCTELWGPGTEVADKSCYNRNEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPW 575

  Fly   837 -------STCRS-----TSE------------------FADKYNIQKGGISLQPGSPCDNFQGYC 871
                   .||::     ||:                  .|:..:|:|...|....|.|.. ...|
Human   576 KGRIVTFLTCKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKG-HAVC 639

  Fly   872 DVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEWIVDN-------WYLVVLMGVAFIVVMGSFIK 929
            |..|:|:..:.                      ||..:       ::..:::||.|.:.:...:.
Human   640 DHELQCQCEEG----------------------WIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVV 682

  Fly   930 CCAVHTPSSNPKKRRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIPPPAHEAQHYSRGGDGRG 994
            ...:...||..|:::.:|       |::|   ....|:::...|:.:  .|.:.|..|
Human   683 AMVIRHQSSREKQKKDQR-------PLST---TGTRPHKQKRKPQMV--KAVQPQEMS------- 728

  Fly   995 GGGGGGGRHGGSRSHHQQHPHDWDRHQGGHSIVPLPTGGSHSSRNS 1040
                            |..||.:|....|:.    |....|...|:
Human   729 ----------------QMKPHVYDLPVEGNE----PPASFHKDTNA 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	61/303 (20%)
		Reprolysin_2	450..659	CDD:290307	45/210 (21%)
		Disintegrin	684..776	CDD:278623	31/92 (34%)
ADAM28	NP_055080.2	Pep_M12B_propep	40..155	CDD:279848	32/118 (27%)
		Cysteine switch. /evidence=ECO:0000250	167..174		3/10 (30%)
		Reprolysin	204..399	CDD:279729	51/249 (20%)
		ZnMc_adamalysin_II_like	204..397	CDD:239797	50/247 (20%)
		Disintegrin	416..488	CDD:278623	31/92 (34%)
		ACR	493..620	CDD:214743	23/129 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	690..775		19/104 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146047
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850