DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and LOC101884782

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_021334457.1	Gene:	LOC101884782 / 101884782	-ID:	-	Length:	760	Species:	Danio rerio

Alignment Length:	673	Identity:	145/673 - (21%)
Similarity:	226/673 - (33%)	Gaps:	226/673 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 KQLHKKSAPQQQQQ--PHPPK--KYISGDEDFKY----PHQKYT----KEANFAEGAFYDPSTGR 365
            :||: .|.||..|.  .:|.:  .|:..:.:..|    .|.|.|    :||:.|:.:|...:.|.
Zfish    37 QQLN-SSGPQDTQHTLSYPSRLIYYLHENSESTYHDLNTHAKTTDPRAQEAHLAQTSFQLQAFGS 100

  Fly   366 R------LGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGREDNK---NTCS-------- 413
            :      |.:....:|:.::.:|..:.....| |:.....|..||.||::   :||:
Zfish   101 QFILDLTLNNDLLSSDYVEIHYEEEKPVLWKG-GEHCYYHGQIRGVEDSRVALSTCNGLHGMFDD 164

  Fly   414 -LYIQT-DPLIWRHIREGIA--------------------------------------------- 431
             :::.| :||...|..||.|
Zfish   165 GVHLYTIEPLNQTHTIEGTARAHVLHRTDLQQSPSAREEGMEEDFSWLRRRKKRAIPRNVFEEMK 229

  Fly   432 --------DHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKID 488
                    ||:..::.:..:.||....|:    |..|:.|::        ||.|.|..:..::|.
Zfish   230 YIELMIVIDHNMFKRLKTKQHTRNNAKSV----VNLVDAIFK--------EHLNTRVVLVAVEIW 282

  Fly   489 DDSACRNSYNGPHNAFCNEHMDVS--------NFLNLHS--LEDHSDFCLAYVFTYRDFTGGTLG 543
            .|               .:.:.||        ||.....  :..|:|       |.:.|:..|
Zfish   283 TD---------------KDRIPVSVTPFEMLRNFSKYRQQHIRQHAD-------TVQLFSNVT-- 323

  Fly   544 LAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGH 608
            ..:..|::...||:|                 ..|...|:|   .|.::   ....|.|:..:..
Zfish   324 FHYPRSSAAYFGGMC-----------------SASHGVGVI---EYGTQ---WTMALQLSQSLAQ 365

  Fly   609 NFGSPHDYPQECRPGGLNGNY---IMFASATSGDRPNNSKFSPCSIRNISNVLDVLVG------N 664
            |.|...|...:.:..|...::   ||..:.....|    .||.|||.:....|  |.|      |
Zfish   366 NLGIQWDSASKRKDCGCVNSWPGCIMEDTGVQHPR----AFSKCSIVSFKEFL--LKGGGSCLFN 424

  Fly   665 TKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQ 729
            .....|:.:|   |||..||.||||||| ..:||...||                |.|:......
Zfish   425 KPSKLFEDTE---CGNGYVEVGEECDCG-PRDECYKDCC----------------KKCSLSNGAH 469

  Fly   730 CSPSQGPCCLSNSCTFVPTSYHQKCK-EETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCI 793
            |  |.|||| :|:|.|.  |....|: ...:|..|.||.|.:..||...|:.|...|:.....|.
Zfish   470 C--SDGPCC-NNTCLFY--SRGHTCRYAVNDCDISETCTGDSGLCPPNLHKQDGYFCSLNQGRCY 529

  Fly   794 RGECS--GSPC-LLWNMTKCFLTSTTLPHVSKRKLC-DLACQDGNDTSTCRSTSEFADKYNIQKG 854
            .|||.  .|.| .:|....          .|..|.| :....:|::...|   ....||:
Zfish   530 AGECKTRDSQCKYVWGPKA----------ASSEKFCYEKLNTEGSEKGNC---GPDGDKW----- 576

  Fly   855 GISLQPGSPCDNFQGYCDVFLKC 877
                   :.|.....:|. ||.|
Zfish   577 -------TQCSKHDVFCG-FLLC 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	60/348 (17%)
		Reprolysin_2	450..659	CDD:290307	41/221 (19%)
		Disintegrin	684..776	CDD:278623	32/92 (35%)
LOC101884782	XP_021334457.1	Pep_M12B_propep	83..189	CDD:307618	24/106 (23%)
		Reprolysin	229..426	CDD:330960	49/261 (19%)
		Disintegrin	441..512	CDD:306668	32/92 (35%)
		ACR	516..657	CDD:214743	21/102 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010