DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and adam28.4

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_031754080.1	Gene:	adam28.4 / 101735040	XenbaseID:	XB-GENE-22167138	Length:	819	Species:	Xenopus tropicalis

Alignment Length:	684	Identity:	152/684 - (22%)
Similarity:	228/684 - (33%)	Gaps:	226/684 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 HRKQLHKKSAPQ-------QQQQP-----HPPKK-------------------YISGDEDF---K 341
            ||..||....|:       :.::|     ||||.                   ::...||.   .
Frog    54 HRPGLHHPHPPKGFTFGPPRNRRPGVHPRHPPKHRHPRMLQYELQLDNKPLVLHLEKTEDLFFRD 118

  Fly   342 YPHQKYTKEAN-------FAEGAFY------DPST-----------------GRRL---GSSANV 373
            |...:|.::..       ..:..:|      ||.:                 ||..   ..||:.
Frog   119 YTETRYLQDGTPTTISPVIKDHCYYQGRVMNDPDSLVSLSTCNGLRGIITTKGRHFLIEPLSASD 183

  Fly   374 ADWHQLVHERVRRATDNGAGDRGSSGG---------SGRGRED----NKNTCSLYIQTDPLIWRH 425
            ::.|.|.....:..:....|...::||         |...:||    :|....||:
Frog   184 SEEHALYPYEPQEVSPTSCGVTYNNGGEDEFRKMSSSFANQEDKILRSKKYVQLYV--------- 239

  Fly   426 IREGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDD 490
                :||:....||   ..::|.|...|...|..||.:|:..         |:...:..|:|.|
Frog   240 ----VADNSMYLKY---NGSKETIKQRIYEMVNYVNMVYKPL---------NVFAALCGIEIWD- 287

  Fly   491 SACRNSYNGPHNA-FCNEHMDVSNFLNLHS--LEDHSDFCLAYVFTYRDFTGGTLGLAWVASASG 552
                   .|...| ..|..::::.|.....  |.......||.:.|..:|.|..:|:|::
Frog   288 -------QGDQIAMLTNSKVNLARFSAWREKVLLPRKQNDLAQLITNINFDGPVVGIAYI----- 340

  Fly   553 ASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYP 617
              |.||    :.|::.|......|.|:..|                 .|.|||:||:.|..|| .
Frog   341 --GMIC----STTQSAGVLQDHNKLSIILG-----------------ATSAHEMGHSLGMYHD-G 381

  Fly   618 QECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCF-------KASEG 675
            :.|   ..|..|.:.::..|...||.  ||.|||.|....|    .||:..|.       .....
Frog   382 KAC---ACNKVYCLMSTKLSSWVPNT--FSTCSINNFQEFL----LNTRPTCLGDIPDKTNILTP 437

  Fly   676 AFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLS 740
            ..||||..|.||:|||| ..:||||:||              .|..|..:...||  ::|.||
Frog   438 PVCGNKFTEMGEDCDCG-TVQECKDQCC--------------DAATCKLKPGAQC--AEGECC-- 483

  Fly   741 NSCTFVPTSYHQKCKEET-ECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECSGSPCL- 803
            ::|......  :.|:|.. :|.....|:||:..||..|.:.:...|..|...|..|.|   |.:
Frog   484 SNCKIKAAG--EVCRERNDDCDLEDVCDGTSPWCPSDRFQANGAPCGKGEGYCYNGTC---PTMQ 543

  Fly   804 -----LWNMTK------CF--------------LTSTTLPHVSKRKLCD-LACQDGND------- 835
                 ||....      ||              :.||.:|...:..:|. |.|...|.
Frog   544 RQCTSLWGENTLVGEDLCFNKNMEGTDYGHCKNVGSTYIPCKPENVMCGVLYCNSDNKYPTVPGR 608

  Fly   836 ---TSTCRSTSEFADKYNIQKGGISLQPGSPCDN 866
               |..|::.  .|.:..:| .||....|..|.|
Frog   609 VAVTGECKAL--LAPEGMVQ-NGIKCGDGKVCYN 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	62/276 (22%)
		Reprolysin_2	450..659	CDD:290307	50/211 (24%)
		Disintegrin	684..776	CDD:278623	29/92 (32%)
adam28.4	XP_031754080.1	Pep_M12B_propep	79..190	CDD:396235	16/110 (15%)
		ZnMc_adamalysin_II_like	233..425	CDD:239797	61/262 (23%)
		DISIN	446..520	CDD:214490	29/94 (31%)
		ACR	522..645	CDD:214743	26/124 (21%)
		Disintegrin	702..775	CDD:395147
		ADAM_CR	779..>808	CDD:417715
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010