DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and LOC100910977

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_003751651.1	Gene:	LOC100910977 / 100910977	RGDID:	6495615	Length:	759	Species:	Rattus norvegicus

Alignment Length:	674	Identity:	148/674 - (21%)
Similarity:	226/674 - (33%)	Gaps:	223/674 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 HRKQ--LHKKSAPQQQQQPHPPKK-----YISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLG 368
            :.||  |||       .||:..|.     |:.||.:|..   ..|..:...:|......|...:.
  Rat   107 YTKQGALHK-------DQPYVQKDCYYHGYMDGDPEFMV---AITTCSGGFQGILQVNGTVYEIK 161

  Fly   369 SSANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTD-PLIWRHIR----E 428
            .....|.:..|||:..|..|:........:....|..:..||.....:|:. ...|.|.|    .
  Rat   162 PKNLSATFEHLVHKIDREGTELLPMRCALTEEIARQLKLQKNENLTLMQSHYEGWWTHKRFLDLA 226

  Fly   429 GIADHDRGRKYEVDEKTR--EEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDS 491
            .:.|.:|.| |..|..:.  .|:.::|    ..:|.||           :.:..|:..:.::
  Rat   227 LVIDRERIR-YHNDNSSHVLVEVFTII----NIINKIY-----------QTLDLELVLLGVE--- 272

  Fly   492 ACRNSYNGPHNAFCNEHMDVSNFLNLHSLED-HSDFC--------------LAYVFTYRDFTGGT 541
                        ..||.    |.:.:|:::. ..:||              :|::|....| |..
  Rat   273 ------------LWNER----NHVPIHNIDVLLYEFCIWKTRSLNFRIPNDIAHLFVNHHF-GIY 320

  Fly   542 LGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEI 606
            ||||:|       |.:|                 ..|||.||...:.:|......:    :|||:
  Rat   321 LGLAYV-------GTVC-----------------MPSLNCGIDRLIGHNLFYFGHI----IAHEM 357

  Fly   607 GHNFGSPHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCS-------------IRNISNVL 658
            |||.|..|| ...|..|..:   .:.|...||.:    |||.||             :|..:..|
  Rat   358 GHNLGMQHD-EGSCTCGAKD---CLMAPTDSGIQ----KFSNCSYSAFWTTYATANCMRKETKPL 414

  Fly   659 DVLVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCT 723
            ..|  .:||          |||.:|:.||:||||..|...:|.||               ...||
  Rat   415 GSL--KSKR----------CGNGVVDDGEQCDCGSAEMCARDPCC---------------KSSCT 452

  Fly   724 RRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEE-TECSWSSTCNGTTAECPEPRHRDDKTMCNN 787
            .:....|  :.|.||  ..|..:|:.  ..|:|: .||.....|||.:.:||...:..|.:.|..
  Rat   453 LKDGATC--AFGLCC--THCRVMPSG--TVCREQVNECDLPEWCNGHSYKCPNDVYLLDGSPCRG 511

  Fly   788 GTALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSKRKLCDLACQDGNDT------STCRSTSEFA 846
            |      |.|                      ..||      |.:.|:.      ...||.::..
  Rat   512 G------GYC----------------------YEKR------CNNRNEQCKQIFGQEARSAAQSC 542

  Fly   847 DKYNIQKGGISLQPGSPCDNFQGYC----DVFLKCRAVDADGPLLRLKN-----LLLNRKT---- 898
            .:....:|          |.| |.|    |.:|:|...|.....|:.:|     ||.:..|
  Rat   543 YRELNTRG----------DRF-GNCGMIRDAYLRCHDSDILCGRLQCENVTGIPLLQDHSTVHWT 596

  Fly   899 -LQTVAEWIVDNWYLVVLMGVAFI 921
             |..|..|..|..:.:.:..|.|:
  Rat   597 RLNGVTCWGTDYHFGMTIPDVGFV 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	63/301 (21%)
		Reprolysin_2	450..659	CDD:290307	48/236 (20%)
		Disintegrin	684..776	CDD:278623	27/92 (29%)
LOC100910977	XP_003751651.1	Pep_M12B_propep	69..176	CDD:279848	19/78 (24%)
		ZnMc_adamalysin_II_like	221..398	CDD:239797	54/248 (22%)
		Disintegrin	428..501	CDD:278623	27/93 (29%)
		ACR	504..640	CDD:214743	31/162 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920