DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam21

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_017455846.2	Gene:	Adam21 / 100910087	RGDID:	6499950	Length:	777	Species:	Rattus norvegicus

Alignment Length:	937	Identity:	175/937 - (18%)
Similarity:	283/937 - (30%)	Gaps:	358/937 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 VEHAKHYF---------------PTNRTATTTPPSTSTTSSATTATKSTQPTRPLAKS---NTST 194
            :||.|..|               |..|:...:||........|...:||:....::.|   ....
  Rat     4 LEHVKITFLPLCLELSLFFFGCPPIGRSQNHSPPEVVIPLRITGTYRSTEDPGWISYSLHFGGQR 68

  Fly   195 TAVNSKTENFIKKIAESTTTSQQLPEYTESSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYK 259
            ..|:.|.:   ||:.                |.|.|.|..|.:....|.:...:::..:|..:..
  Rat    69 HIVHMKAK---KKLV----------------SRSLTVFTYTDQGALLEDQPFVQNDCYYHGYVEG 114

  Fly   260 ESH----VEDAYENVREGHVAGCGITDEVSQWMENIQNSAVEELPEPMSKDYQKLHRKQLHKKSA 320
            :.:    :.....|: :|.:...|||.|:.              |:.:|..::.|..|.
  Rat   115 DPNSMVTLTTCLGNI-QGMLQTNGITYEIK--------------PKVVSATFEHLVYKM------ 158

  Fly   321 PQQQQQPHPPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHE--- 382
             ..:...:.|...|...|:.       .::..|.|.   |.||   |..|:.:. |  |:|:
  Rat   159 -DMEDTEYTPTGCILTKEEI-------AEQLKFQEN---DNST---LMQSSYIG-W--LLHQWFL 206

  Fly   383 RVRRATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTRE 447
            .:....|:|.                            .|:|:....|.:.|
  Rat   207 ELAIVVDHGR----------------------------FIFRNSNSSIVEMD------------- 230

  Fly   448 EITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVS 512
                 :...|..|:.|||:...|           |..|.|:..:|     ..|:......|| :.
  Rat   231 -----VVMGVNLVDDIYRSVNLD-----------VVLIAIEIWNA-----GNPYKVTTTHHM-ME 273

  Fly   513 NF-------LNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGG 570
            ||       .|...:.|.     |::...:||....|..::.:       |:|
  Rat   274 NFCKWKQFSFNKRVVHDS-----AHIIVKQDFCVNDLTASYFS-------GVC------------ 314

  Fly   571 QYQSTKRSLNTG--------IITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGLNG 627
                 ..:||.|        :.:|..|            :.|||||..|..:|          .|
  Rat   315 -----NINLNCGLECIMDDRLASFRTY------------MTHEIGHVLGMMND----------EG 352

  Fly   628 NY--------IMFASATSGDRPNNSKFSPCS-------------IRNISNVLDVLVGNTKRDCFK 671
            ||        ||....:..|     .||.||             :.|..|...::   ||:.
  Rat   353 NYCTCGRNICIMNKKLSPSD-----AFSNCSYEQFLETTFRKTCLHNFPNPETII---TKKR--- 406

  Fly   672 ASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGP 736
                  |||.::|..||||||..:...:|.||               .:.||..:...|  :.|.
  Rat   407 ------CGNGVIEDEEECDCGSLKLCAQDVCC---------------LENCTLVSGAAC--AAGE 448

  Fly   737 CCLSNSCTFVPTSYHQKCKEETE-CSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECSGS 800
            ||  .:|.|:|:.  ..|:|... |.....||||:..|||..:.:|...| .|.::|.:..|:
  Rat   449 CC--QNCKFMPSG--TVCRERNNPCDLPEWCNGTSGACPEDVYVEDGVYC-QGRSICFQKRCN-- 506

  Fly   801 PCLLWNMTKCFLTSTTLPHVSKRKLCDLACQDG--NDTSTCRSTSEFADKYNIQKGGISLQPGSP 863
                                |:.:.|.....:|  |....|                 .|...|.
  Rat   507 --------------------SRDQQCRQLFGEGAKNANKNC-----------------YLAMNSR 534

  Fly   864 CDNFQGYCDV----FLKCRAVDADGPLLRLKNL-----LLNRKTLQTV-----AEWIVDNWYLVV 914
            .|.| |:|.:    :::|...||....::.:|:     |.|..|:.:.     :.|..|..:.:.
  Rat   535 GDRF-GHCGMKNTKYIRCNKQDALCGRVQCENVTEVPRLHNHSTVHSTHINGFSCWSTDYHFGMS 598

  Fly   915 LMGVAFI---VVMGSFIKC----CAVHTPSSN---PKKRRARRISETLRAPMNTLRRMQRHPNQR 969
            :..:..:   ...||...|    |....|...   |.....|.|..         .:...|.|:.
  Rat   599 VPDIGDVKDGTECGSDFLCLESKCVFMPPWEELCMPTFCNKRGICN---------NKHHCHCNEH 654

  Fly   970 GAGPRSI-----------PPPAHEAQH 985
            .|.|..:           |||....||
  Rat   655 WAPPNCLNKGFGGSIDSGPPPKRLTQH 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	53/302 (18%)
		Reprolysin_2	450..659	CDD:290307	47/244 (19%)
		Disintegrin	684..776	CDD:278623	28/92 (30%)
Adam21	XP_017455846.2	Pep_M12B_propep	38..156	CDD:396235	24/151 (16%)
		ZnMc_adamalysin_II_like	204..394	CDD:239797	51/308 (17%)
		Disintegrin	413..485	CDD:395147	28/92 (30%)
		ACR	490..623	CDD:214743	28/173 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339797
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850