DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and adam28.3

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_031755156.1	Gene:	adam28.3 / 100498252	XenbaseID:	XB-GENE-22167131	Length:	674	Species:	Xenopus tropicalis

Alignment Length:	650	Identity:	141/650 - (21%)
Similarity:	209/650 - (32%)	Gaps:	222/650 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 HERVRRATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKT 445
            |..|..:|.||.        ||          |:..|....:...::|  .|.:....||.|.|.
Frog   113 HSLVSLSTCNGL--------SG----------SIMTQGHTFLIEPLKE--TDSEEHAFYEYDPKA 157

  Fly   446 ---------------REEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRN 495
                           .|..|:.....:|....|..::|:            ||...:.|.|..:
Frog   158 DTSKACGVTSSNMPEGEFNTASYTMDLTEKQEILNSSKY------------VQLYVVADYSMVQ- 209

  Fly   496 SYNGPHNAFCNEHMDVSNFLNL--------------HSLEDHSDF--------CLAYVFTYRD-- 536
            .|||......|....:.|:.|:              ...|:...|        ||.....:||
Frog   210 KYNGSVETIKNRIFQMMNYNNMVYKALNVFIALCGVEFWENGDQFPVPSPANECLGNFSEWRDKN 274

  Fly   537 -----------------FTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGII 584
                             |....:|||:|       ||:|          .|::       :.|:|
Frog   275 LVPRKLHDAAVFLTNVKFVAPLVGLAYV-------GGMC----------FGRF-------SAGVI 315

  Fly   585 TFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQ-ECRPGG-LNGNYIMFASATSGDRPNNSKFS 647
            ...:..:.:...:    :|||:|||||..||... .|.... :...|:...:.|        .||
Frog   316 NDYSKEATIVASI----IAHEVGHNFGMNHDSTDCSCSSASCIMSKYVSPVAPT--------LFS 368

  Fly   648 PCSIRNISNVL---------------DVLVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEE 697
            .|||....|.|               |:|.            ...||||..|.||:|||| ..:|
Frog   369 NCSISAFQNFLLTKNPTCISDIPDKPDILT------------PPVCGNKFTEVGEDCDCG-TVQE 420

  Fly   698 CKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEETECSW 762
            ||:.||              .|..|.::...||  :.|.||  ::| .:..:.|.....:.:|..
Frog   421 CKNPCC--------------DAATCKKKPNVQC--TGGECC--DNC-MIKAAGHVCRASKGDCDL 466

  Fly   763 SSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGEC-----------------SGSPCLLWNMT-- 808
            ...|||.::.||..|.|.:...||||...|..|.|                 ||:.|...|..
Frog   467 DDLCNGVSSSCPSDRFRVNGLPCNNGRGYCYNGSCPTMLNQCNAIWGVDSAVSGNSCFNMNTNGV 531

  Fly   809 ---KCFLTSTT-LPHVSKRKLCD-LACQDGN----------DTSTCRSTSEFADKYNIQKGGISL 858
               .|....|| :|..::..:|. |.|.:|.          .|..|::....|.|.   :.|...
Frog   532 IYGHCKQNGTTYVPCAAEDIMCGVLFCINGTTFPLISAPFVTTPACKALLSPAGKV---QSGAKC 593

  Fly   859 QPGSPCDNFQGYC----DVFLKCRAVDADGPLLRLKNLLLNRKTL-QTVAEWIVDNWYLVVLMGV 918
            ..|..|.|.|  |    ..::.....|:..|    ||.:.:.:.: |....|:..|..:.|..||
Frog   594 GNGKVCSNNQ--CVTTETAYIGSSGCDSKCP----KNAVCDHELICQCTKGWVPPNCNVAVTSGV 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	62/339 (18%)
		Reprolysin_2	450..659	CDD:290307	51/266 (19%)
		Disintegrin	684..776	CDD:278623	27/91 (30%)
adam28.3	XP_031755156.1	Pep_M12B_propep	31..150	CDD:396235	11/56 (20%)
		ZnMc_adamalysin_II_like	195..389	CDD:239797	48/242 (20%)
		DISIN	408..482	CDD:214490	27/93 (29%)
		ACR	485..605	CDD:214743	28/124 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010